Research

Antisense RNAs Influence Promoter Usage of Their Counterpart Sense Genes in Cancer. (Cancer Res, Dec 2021)

Fernando Bellido Molias 1, Andre Sim 2, Ka Wai Leong 1, Omer An 1, Yangyang Song 1, Vanessa Hui En Ng 1, Max Wei Jie Lim 1, Chen Ying 2, Jasmin Xin Jia Teo 1, Jonathan Göke 3, Leilei Chen 4 5 6 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, …

Antisense RNAs Influence Promoter Usage of Their Counterpart Sense Genes in Cancer. (Cancer Res, Dec 2021) Read More »

Pseudogene-Mediated DNA Demethylation Leads to Oncogene Activation. (Sci Adv, Oct 2021)

Authors Junsu Kwon 1, Yanjing V Liu 1, Chong Gao 2, Mahmoud A Bassal 1 3, Adrianna I Jones 3, Junyu Yang 2, Zhiyuan Chen 2, Ying Li 1, Henry Yang 1, Leilei Chen 1, Annalisa Di Ruscio 4 5 6, Yvonne Tay 1 7, Li Chai 2, Daniel G Tenen 1 3 4 Affiliations 1Cancer Science Institute of Singapore, National University of …

Pseudogene-Mediated DNA Demethylation Leads to Oncogene Activation. (Sci Adv, Oct 2021) Read More »

Enhanced Penetrative siRNA Delivery by a Nanodiamond Drug Delivery Platform Against Hepatocellular Carcinoma 3D Models. (Nanoscale, Oct 2021)

Authors Jingru Xu 1 2, Mengjie Gu 1 2, Lissa Hooi 2, Tan Boon Toh 3, Dexter Kai Hao Thng 2, Jhin Jieh Lim 2, Edward Kai-Hua Chow 1 2 3 4 5 6 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore. csikce@nus.edu.sg. 2Department of Pharmacology, …

Enhanced Penetrative siRNA Delivery by a Nanodiamond Drug Delivery Platform Against Hepatocellular Carcinoma 3D Models. (Nanoscale, Oct 2021) Read More »

Integrative Epigenomic and High-Throughput Functional Enhancer Profiling Reveals Determinants of Enhancer Heterogeneity in Gastric Cancer. (Genome Med, Oct 2021)

Authors Taotao Sheng # 1 2, Shamaine Wei Ting Ho # 2 3, Wen Fong Ooi 4, Chang Xu 2 3, Manjie Xing 2 4, Nisha Padmanabhan 2, Kie Kyon Huang 2, Lijia Ma 5, Mohana Ray 5, Yu Amanda Guo 6, Ngak Leng Sim 6, Chukwuemeka George Anene-Nzelu 7 8 9 10, Mei Mei Chang 6, Milad Razavi-Mohseni 11, Michael A Beer 11, Roger Sik Yin Foo 7 8, Raghav Sundar 2 12, Yiong …

Integrative Epigenomic and High-Throughput Functional Enhancer Profiling Reveals Determinants of Enhancer Heterogeneity in Gastric Cancer. (Genome Med, Oct 2021) Read More »

Determinants of Response to Daratumumab in Epstein-Barr Virus-Positive Natural Killer and T-Cell Lymphoma. (J Immunother Cancer, Jul 2021)

Nurulhuda Mustafa 1 2, Adina Huey Fang Nee 2, Jing Yuan Chooi 3, Sabrina Hui Min Toh 2, Tae-Hoon Chung 2, Viknesvaran Selvarajan 4, Shuangyi Fan 4, Siok Bian Ng 2 4 5, Michelle Poon 6, Esther Chan 6, Joanne Lee 6, Yen Lin Chee 6, Anand D Jeyasekharan 2 6, Longen Zhou 7, Jennifer Yang 7, Wee Joo Chng 3 2 6 Affiliations 1Department of Medicine, …

Determinants of Response to Daratumumab in Epstein-Barr Virus-Positive Natural Killer and T-Cell Lymphoma. (J Immunother Cancer, Jul 2021) Read More »

Chromatin Interaction Neural Network (ChINN): A Machine Learning-Based Method for Predicting Chromatin Interactions from DNA Sequences. (Genome Biol, Aug 2021)

Fan Cao # 1, Yu Zhang # 2, Yichao Cai # 1, Sambhavi Animesh 1, Ying Zhang 1, Semih Can Akincilar 3, Yan Ping Loh 1, Xinya Li 4, Wee Joo Chng 1 5 6, Vinay Tergaonkar 3 7, Chee Keong Kwoh 2, Melissa J Fullwood 8 9 10 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, 14 Medical …

Chromatin Interaction Neural Network (ChINN): A Machine Learning-Based Method for Predicting Chromatin Interactions from DNA Sequences. (Genome Biol, Aug 2021) Read More »