Latest @ CSI.

October 3, 2024
Recipients of The Distinguished Senior Clinician Award (DSCA), Prof Chng Wee Joo and Prof. Lee Soo Chin
Warmest congratulations to CSI Senior Principal Investigators, Prof. Chng Wee Joo and Prof. Lee Soo Chin for being awarded, The Distinguished Senior Clinician Award (DSCA). The Ministry of Health grants...
July 26, 2024
CSI PhD Graduation Party 2024
Celebrating Success! On July 12th, we gathered to honour an incredible achievement—the graduation of our brilliant PhD students who have dedicated the past 4-5 years to the field of cancer...

Press Release

Oncogenic Dependency on SWI/SNF Chromatin Remodeling Factors in T-cell Acute Lymphoblastic Leukemia (Leukemia, Jul 2024)

Hyoju Kim 1, Tze King Tan 1, Dean Zi Yang Lee 1, Xiao Zi Huang 1, Jolynn Zu Lin Ong 1, Michelle A Kelliher 2, Allen Eng Juh Yeoh 1 3, Takaomi Sanda 4 5 6, Shi Hao Tan 1 Affiliations 1Cancer Science Institute of Singapore, National University of, Singapore, …

Oncogenic Dependency on SWI/SNF Chromatin Remodeling Factors in T-cell Acute Lymphoblastic Leukemia (Leukemia, Jul 2024) Read More »

PARP4 Interacts with hnRNPM to Regulate Splicing during Lung Cancer Progression (Genome Medicine, Jul 2024)

Yi Fei Lee 1 2, Cheryl Zi Jin Phua 1, Ju Yuan 1, Bin Zhang 3 4 5, May Yin Lee 1, Srinivasaraghavan Kannan 6, Yui Hei Jasper Chiu 1, Casslynn Wei Qian Koh 1, Choon Kong Yap 1, Edwin Kok Hao Lim 1, Jianbin Chen 1, Yuhua Lim 1, Jane Jia Hui Lee 1, Anders Jacobsen Skanderup 1, Zhenxun Wang 1 7, Weiwei …

PARP4 Interacts with hnRNPM to Regulate Splicing during Lung Cancer Progression (Genome Medicine, Jul 2024) Read More »

Hepatocyte-macrophage Crosstalk via the PGRN-EGFR Axis Modulates ADAR1-mediated Immunity in the Liver (Cell Reports, Jun 2024)

Wei Liang Gan 1, Xi Ren 1, Vanessa Hui En Ng 1, Larry Ng 1, Yangyang Song 1, Vincent Tano 1, Jian Han 1, Omer An 1, Jinghe Xie 2, Bryan Y L Ng 1, Daryl Jin Tai Tay 1, Sze Jing Tang 1, Haoqing Shen 1, Shruti Khare 3, Kelvin Han Chung Chong 4, Dan Yock Young 5, Bin Wu 4, Ramanuj DasGupta 3, Leilei …

Hepatocyte-macrophage Crosstalk via the PGRN-EGFR Axis Modulates ADAR1-mediated Immunity in the Liver (Cell Reports, Jun 2024) Read More »

A PRMT5-ZNF326 Axis Mediates Innate Immune Activation Upon Replication Stress (Science Advances, Jun 2024)

Phuong Mai Hoang 1, Denis Torre 2 3 4, Patrick Jaynes 1, Jessica Ho 5, Kevin Mohammed 2 3 4 6, Erik Alvstad 7 8, Wan Yee Lam 4 6, Vartika Khanchandani 1, Jie Min Lee 1, Chin Min Clarissa Toh 1, Rui Xue Lee 1, Akshaya Anbuselvan 1, Sukchan Lee 9, Robert P Sebra 4, Martin J Walsh 4 6, Ivan Marazzi 7 8, Dennis Kappei 1 10 11, Ernesto Guccione 2 3 4 6, Anand D Jeyasekharan 1 11 12 13 Affiliations …

A PRMT5-ZNF326 Axis Mediates Innate Immune Activation Upon Replication Stress (Science Advances, Jun 2024) Read More »

Spatially-resolved Transcriptomics Reveal Macrophage Heterogeneity and Prognostic Significance in Diffuse Large B-cell Lymphoma (Nature Communications, Mar 2024)

Min Liu 1 2 3, Giorgio Bertolazzi 4 5, Shruti Sridhar 1, Rui Xue Lee 1, Patrick Jaynes 1, Kevin Mulder 6 7 8, Nicholas Syn 9 10, Michal Marek Hoppe 1, Shuangyi Fan 9, Yanfen Peng 1, Jocelyn Thng 1, Reiya Chua 11, Jayalakshmi 11, Yogeshini Batumalai 11, Sanjay De Mel 11 12, Limei Poon 11 12, Esther Hian Li Chan 11 12, Joanne Lee 11 12, Susan Swee-Shan Hue 9 12, Sheng-Tsung Chang 13, Shih-Sung Chuang 13, K George Chandy 14, Xiaofei Ye 15, Qiang …

Spatially-resolved Transcriptomics Reveal Macrophage Heterogeneity and Prognostic Significance in Diffuse Large B-cell Lymphoma (Nature Communications, Mar 2024) Read More »

Deciphering the Regulatory Landscape of Murine Splenic Response to Anemic Stress at Single-cell Resolution (Blood Advances, Feb 2024)

Chong Yang 1, Rui Yokomori 1, Lee Hui Chua 1, Shi Hao Tan 1, Mun Yee Koh 1, Haruhito Totani 1, Takaomi Sanda 1, Toshio Suda 1 2 Affiliations 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 2International …

Deciphering the Regulatory Landscape of Murine Splenic Response to Anemic Stress at Single-cell Resolution (Blood Advances, Feb 2024) Read More »

Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer (Cancer Research Communications – AACR Journals, Jan 2024)

Kazuto Suda 1, Atsushi Okabe 2, Junichi Matsuo 1, Linda Shyue Huey Chuang 1, Ying Li 1, Nawaphat Jangphattananont 1, Naing Naing Mon 1, Khine Nyein Myint 1, Akihiro Yamamura 1, Jimmy Bok-Yan So 3, Dominic Chih-Cheng Voon 4, Henry Yang 1, Khay Guan Yeoh 5 6, Atsushi Kaneda 2, Yoshiaki Ito 1 Affiliations 1Cancer Science Institute of Singapore, National …

Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer (Cancer Research Communications – AACR Journals, Jan 2024) Read More »

A Glycolytic Metabolite Bypasses “two-hit” Tumor Suppression by BRCA2 (Cell, Apr 2024)

Kong LR, Gupta K, Wu AJ, Perera D, Ivanyi-Nagy R, Ahmed SM, Tan TZ, Tan SL, Fuddin A, Sundaramoorthy E, Goh GS, Wong RTX, Costa ASH, Oddy C, Wong H, …

A Glycolytic Metabolite Bypasses “two-hit” Tumor Suppression by BRCA2 (Cell, Apr 2024) Read More »

Novel Sequence Searching Algorithm Significantly Boost the Power of AI-based Protein-Protein Complex Structure Prediction

Over the past short couple of years, artificial intelligence (AI) and deep-learning techniques have revolutionised protein-structure predictions, and as such have accelerated our understanding in corelating biological functions with protein/RNA …

Novel Sequence Searching Algorithm Significantly Boost the Power of AI-based Protein-Protein Complex Structure Prediction Read More »

Phase II Study of Trifluridine/Tipiracil in Metastatic Breast Cancers with or without Prior Exposure to Fluoropyrimidines (Eur J Cancer, Oct 2023)

Joline S J Lim 1, Samuel G W Ow 2, Andrea L A Wong 3, Matilda X W Lee 2, Gloria H J Chan 2, Jia Li Low 2, Raghav Sundar 4, Joan R E Choo 2, Wan Qin Chong 2, Yvonne L E Ang 2, Bee Choo Tai 5, Soo Chin …

Phase II Study of Trifluridine/Tipiracil in Metastatic Breast Cancers with or without Prior Exposure to Fluoropyrimidines (Eur J Cancer, Oct 2023) Read More »

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