Latest @ CSI.

October 7, 2026

🎉 Congratulations to Dr Seungjae Lee on being named a Life Sciences Finalist in the 2026 Blavatnik Regional Awards for Young Scientists!

Dr Lee is recognised for uncovering an unexpected connection between cellular metabolism and RNA regulation. His research revealed that the metabolic enzyme ALAS1 can suppress RNA interference—a process that switches...

August 4, 2026

🎳✨ What a fantastic afternoon at the CSI Staff Party 2026!

A heartfelt thank you to everyone who joined us and made this year's staff party such a fun and memorable occasion. It was wonderful to see colleagues coming together to...

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DDX6 induces immunosuppression in cancer by disrupting structural stability of endogenous double-stranded RNAs

Cancer cells can avoid detection by suppressing the warning signals that would alert the immune system.Led by Associate Professor Polly Chen, the team found that a protein called DDX6 helps […]

qChIP-MS reveals the local chromatin composition by label-free quantitative proteomics

Researchers led by Principal Investigator, Assistant Professor Dennis Kappei, have developed a new method that allows scientists to better understand how DNA activity is organised and regulated inside our cells. […]

An Analytic Framework Characterizes the Biological Processes That Shape Copy Number–Based Genome Instability Patterns in Breast Cancer

A study led by Principal Investigator, Dr. Jason Pitt, has identified eight new “signatures” of DNA patterns (gains and/or losses) in breast cancer. By analysing nearly 2,800 genomes, the team […]

A Paired Sequence Language Model for Protein-Protein Interaction Modeling

Researchers led by Senior Principal Investigator, Professor Zhang Yang, have developed a new artificial intelligence (AI) model that can more accurately predict how proteins interact with one another—an advance that […]

Learned Conformational Space and Pharmacophore into Molecular Foundational Model

A key challenge in AI-driven drug discovery is moving beyond molecular analysis to enable chemically meaningful molecular design. In a newly published study in Advanced Science, researchers led by Senior […]

Pembrolizumab Plus Lenvatinib in Recurrent Gynaecological Clear Cell Carcinoma (LARA): A Multicentre, Single-Arm, Phase 2 Trial (The LANCET Oncology, Feb 2026)

A multinational study led by Principal Investigator A/Prof. David Tan and collaborators from Singapore and South Korea has demonstrated encouraging results for patients with recurrent clear cell ovarian and endometrial […]

Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer (Cell Metabolism Nov 2025)

Authors Zhengwei Wu , Zhenxun Wang , Seow Qi Ng , Jessica Alice Lidster , Paul Schwerd-Kleine , Zi Jin Cheryl Phua , Kai Lay Esther Peh , Yin Ying […]

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Pragmatic Interventions to Boost Surveillance Mammogram Uptake Among an Overdue Population A Randomized Clinical Trial (JAMA Internal Medicine, Nov 2025)

Authors Soo-Chin Lee, Sasidharan Swarnalatha Lucky, Junxian Zhu, Samuel Ow, Lukas Loh, Jun Hui Tan, Siew Eng Lim, Zarinah Hairom, Shivan Mehta 6, Bee-Choo Tai, Boon-Cher Goh Abstract Led by […]

Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone (JCI, July 2025)

Authors: Valeria Cancila, Giorgio Bertolazzi, Allison S.Y. Chan, Giovanni Medico, Giulia Bastianello, Gaia Morello, Daniel Paysan, Clemence Lai, Liang Hong, Girija Shenoy, Patrick W. Jaynes, Giovanna Schiavoni, Fabrizio Mattei, Silvia […]

Prospective Clinical Validation of a Combinatorial Functional Precision Medicine Platform in Relapsed/Refractory Non-Hodgkin’s Lymphoma (JCO Precision Oncology, September 2025)

Treating patients whose non-Hodgkin’s lymphoma (NHL) has come back or stopped responding to therapy remains very difficult. Many eventually run out of standard treatment options. A team led by Dr. […]

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