Research

An Analytic Framework Characterizes the Biological Processes That Shape Copy Number–Based Genome Instability Patterns in Breast Cancer

 A study led by Principal Investigator, Dr. Jason Pitt, has identified eight new “signatures” of DNA patterns (gains and/or losses) in breast cancer. By analysing nearly 2,800 genomes, the team

An Analytic Framework Characterizes the Biological Processes That Shape Copy Number–Based Genome Instability Patterns in Breast Cancer Read More »

Pembrolizumab Plus Lenvatinib in Recurrent Gynaecological Clear Cell Carcinoma (LARA): A Multicentre, Single-Arm, Phase 2 Trial (The LANCET Oncology, Feb 2026)

A multinational study led by Principal Investigator A/Prof. David Tan and collaborators from Singapore and South Korea has demonstrated encouraging results for patients with recurrent clear cell ovarian and endometrial

Pembrolizumab Plus Lenvatinib in Recurrent Gynaecological Clear Cell Carcinoma (LARA): A Multicentre, Single-Arm, Phase 2 Trial (The LANCET Oncology, Feb 2026) Read More »

Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer (Cell Metabolism Nov 2025)

Authors Zhengwei Wu , Zhenxun Wang , Seow Qi Ng , Jessica Alice Lidster , Paul Schwerd-Kleine , Zi Jin Cheryl Phua , Kai Lay Esther Peh , Yin Ying

Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer (Cell Metabolism Nov 2025) Read More »

Pragmatic Interventions to Boost Surveillance Mammogram Uptake Among an Overdue Population A Randomized Clinical Trial (JAMA Internal Medicine, Nov 2025)

Authors Soo-Chin Lee, Sasidharan Swarnalatha Lucky, Junxian Zhu, Samuel Ow, Lukas Loh, Jun Hui Tan, Siew Eng Lim, Zarinah Hairom, Shivan Mehta 6, Bee-Choo Tai, Boon-Cher Goh Abstract Led by

Pragmatic Interventions to Boost Surveillance Mammogram Uptake Among an Overdue Population A Randomized Clinical Trial (JAMA Internal Medicine, Nov 2025) Read More »

Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone (JCI, July 2025)

Authors: Valeria Cancila, Giorgio Bertolazzi, Allison S.Y. Chan, Giovanni Medico, Giulia Bastianello, Gaia Morello, Daniel Paysan, Clemence Lai, Liang Hong, Girija Shenoy, Patrick W. Jaynes, Giovanna Schiavoni, Fabrizio Mattei, Silvia

Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone (JCI, July 2025) Read More »

Prospective Clinical Validation of a Combinatorial Functional Precision Medicine Platform in Relapsed/Refractory Non-Hodgkin’s Lymphoma (JCO Precision Oncology, September 2025)

Treating patients whose non-Hodgkin’s lymphoma (NHL) has come back or stopped responding to therapy remains very difficult. Many eventually run out of standard treatment options. A team led by Dr.

Prospective Clinical Validation of a Combinatorial Functional Precision Medicine Platform in Relapsed/Refractory Non-Hodgkin’s Lymphoma (JCO Precision Oncology, September 2025) Read More »