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“Cancer fishing”: CSI Singapore Researchers Discover New Mechanisms of Cancer using Zebrafish and Single-cell Sequencing Technology

For decades, scientists and doctors have been searching for the mechanisms underlying the formation of cancers.  Accumulating studies have revealed that each cancer type (e.g. gastric cancer, lung cancer, leukemia, […]

“Cancer fishing”: CSI Singapore Researchers Discover New Mechanisms of Cancer using Zebrafish and Single-cell Sequencing Technology Read More »

CSI Principal Investigator and Senior Research Scientist Receive Awards at the Asian Fund for Cancer Research’s (AFCR) 2021 BRACE Award Venture Competition

Congratulations to A/Prof. Edward Kai-Hua Chow and Dr. Bee Hui Liu, who have recently won awards at the Asian Fund for Cancer Research’s (AFCR) 2021 BRACE Award Venture Competition, a

CSI Principal Investigator and Senior Research Scientist Receive Awards at the Asian Fund for Cancer Research’s (AFCR) 2021 BRACE Award Venture Competition Read More »

Phase Ib/II Dose Expansion Study of Lenvatinib Combined with Letrozole in Post-Menopausal Women with Hormone Receptor Positive Breast Cancer (Clin Cancer Res, Apr 22)

Joline S J Lim 1, Andrea L A Wong 2, Samuel G W Ow 1, Natalie Y L Ngoi 3, Gloria H J Chan 4, Yvonne L E Ang 5, Wan Qin Chong 6, Siew Eng Lim 4, Yi Wan Lim 6, Matilda Lee 4, Joan R E Choo 7, Hon Lyn

Phase Ib/II Dose Expansion Study of Lenvatinib Combined with Letrozole in Post-Menopausal Women with Hormone Receptor Positive Breast Cancer (Clin Cancer Res, Apr 22) Read More »

Non-Coding RNA LEVER Sequestration of PRC2 Can Mediate Long Range Gene Regulation (Commun Biol, Apr 22)

Wei Wen Teo # 1, Xinang Cao # 1 2, Chan-Shuo Wu 1, Hong Kee Tan 1 3, Qiling Zhou 1, Chong Gao 4, Kim Vanuytsel 5 6, Sara S Kumar 5 6, George J Murphy 5 6, Henry Yang 1, Li Chai 7, Daniel G Tenen 8 9 10 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

Non-Coding RNA LEVER Sequestration of PRC2 Can Mediate Long Range Gene Regulation (Commun Biol, Apr 22) Read More »

Multilayered Control of Splicing Regulatory Networks by DAP3 Leads to Widespread Alternative Splicing Changes in Cancer. (Nat Commun, Apr 22)

Jian Han 1, Omer An 2, Xi Ren 2, Yangyang Song 2, Sze Jing Tang 2, Haoqing Shen 2, Xinyu Ke 2, Vanessa Hui En Ng 2, Daryl Jin Tai Tay 2, Hui Qing Tan 3, Dennis Kappei 2 4 5, Henry Yang 2, Leilei Chen 6 7 8 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore,

Multilayered Control of Splicing Regulatory Networks by DAP3 Leads to Widespread Alternative Splicing Changes in Cancer. (Nat Commun, Apr 22) Read More »

PLK1 Inhibition Selectively Induces Apoptosis in ARID1A Deficient Cells Through Uncoupling of Oxygen Consumption from ATP Production. (Oncogene, Mar 22)

Upadhyayula S Srinivas # 1, Norbert S C Tay # 1, Patrick Jaynes # 1, Akshaya Anbuselvan 1, Gokula K Ramachandran 1, Joanna D Wardyn 1, Michal M Hoppe 1, Phuong Mai Hoang 1, Yanfen Peng 1, Sherlly Lim 1, May Yin Lee 2, Praveen C Peethala 1, Omer An 1, Akshay Shendre 1, Bryce W Q Tan 1, Sherlyn Jemimah 1, Manikandan Lakshmanan 3, Longyu Hu 4, Rekha

PLK1 Inhibition Selectively Induces Apoptosis in ARID1A Deficient Cells Through Uncoupling of Oxygen Consumption from ATP Production. (Oncogene, Mar 22) Read More »

Clinical Translation of Patient-Derived Tumour Organoids- Bottlenecks and Strategies. (Biomark Res, Mar 22)

Malia Alexandra Foo # 1, Mingliang You # 2 3, Shing Leng Chan 1 4, Gautam Sethi 5 6, Glenn K Bonney 4 5, Wei-Peng Yong 1 7, Edward Kai-Hua Chow 1 5 6, Eliza Li Shan Fong 1 8, Lingzhi Wang 9 10 11, Boon-Cher Goh 12 13 14 15 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Hangzhou

Clinical Translation of Patient-Derived Tumour Organoids- Bottlenecks and Strategies. (Biomark Res, Mar 22) Read More »

ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022)

Haoqing Shen 1 2, Omer An 1, Xi Ren 1, Yangyang Song 1, Sze Jing Tang 1, Xin-Yu Ke 1 2, Jian Han 1, Daryl Jin Tai Tay 1, Vanessa Hui En Ng 1, Fernando Bellido Molias 1, Priyankaa Pitcheshwar 1 2, Ka Wai Leong 1, Ker-Kan Tan 3 4 5, Henry Yang 1, Leilei Chen 6 7 8 Affiliations 1Cancer Science Institute of Singapore, National

ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022) Read More »