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An ex vivo Platform to Guide Drug Combination Treatment in Relapsed/Refractory Lymphoma (Sci Transl Med, Oct 2022)

Jasmine Goh 1, Sanjay De Mel 2 3, Michal M Hoppe 1, Masturah Bte Mohd Abdul Rashid 4, Xi Yun Zhang 1, Patrick Jaynes 1, Esther Ka Yan Ng 1, Nur’Atiqa Diana Binti Rahmat 1, Jayalakshmi 1, Clementine Xin Liu 3, Limei Poon 2 3, Esther Chan 2 3, Joanne Lee 2 3, Yen Lin Chee 2 3, Liang Piu Koh 3, Lip Kun Tan 5, Teck […]

An ex vivo Platform to Guide Drug Combination Treatment in Relapsed/Refractory Lymphoma (Sci Transl Med, Oct 2022) Read More »

Mitochondria Transfer Mediates Stress Erythropoiesis by Altering the Bioenergetic Profiles of early Erythroblasts through CD47 (J Exp Med, Sep 2022)

Chong Yang 1, Rui Yokomori 1, Lee Hui Chua 1, Shi Hao Tan 1, Darren Qiancheng Tan 1, Kenichi Miharada 2, Takaomi Sanda 1, Toshio Suda 1 2 Affiliations 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Mitochondria Transfer Mediates Stress Erythropoiesis by Altering the Bioenergetic Profiles of early Erythroblasts through CD47 (J Exp Med, Sep 2022) Read More »

A Genomic-augmented Multivariate Prognostic Model for the Survival of Natural-killer/T-cell Lymphoma Patients from an International Cohort (Am J Hematol, Jun 2022)

With lowering costs of sequencing and genetic profiling techniques, genetic drivers can now be detected readily in tumors but current prognostic models for Natural-killer/T cell lymphoma (NKTCL) have yet to fully leverage on them for prognosticating patients.

A Genomic-augmented Multivariate Prognostic Model for the Survival of Natural-killer/T-cell Lymphoma Patients from an International Cohort (Am J Hematol, Jun 2022) Read More »

A Degradative to Secretory Autophagy Switch Mediates Mitochondria Clearance in the Absence of the mATG8-conjugation Machinery (Nat Commun., Jun 2022)

PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the most important mechanisms in mitochondrial quality control (MQC) via the clearance of damaged mitochondria.

A Degradative to Secretory Autophagy Switch Mediates Mitochondria Clearance in the Absence of the mATG8-conjugation Machinery (Nat Commun., Jun 2022) Read More »

Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities (Gut, Jul 2022)

According to GLOBOCAN, gastric cancer (GC) is a significant cause of cancer mortality worldwide, with over 700,000 deaths attributable to it annually. Mesenchymal-subtype gastric cancer (Mes-GC) is a particularly aggressive

Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities (Gut, Jul 2022) Read More »