Chromatin interactions play significant roles in regulating gene expression. To date, the understanding of the determinants of chromatin interactions remains elusive. Identification of chromatin interaction biomarkers in normal and cancer […]

Natural Killer T cell lymphoma (NKTL) is a highly aggressive form of cancer more frequently occurring in Asia than other parts of the world with very poor treatment outcomes in

Nurulhuda Mustafa 1 2, Adina Huey Fang Nee 2, Jing Yuan Chooi 3, Sabrina Hui Min Toh 2, Tae-Hoon Chung 2, Viknesvaran Selvarajan 4, Shuangyi Fan 4, Siok Bian Ng 2 4 5, Michelle Poon 6, Esther Chan 6, Joanne Lee 6, Yen Lin Chee 6, Anand D Jeyasekharan 2 6, Longen Zhou 7, Jennifer Yang 7, Wee Joo Chng 3 2 6 Affiliations 1Department of Medicine,

Fan Cao # 1, Yu Zhang # 2, Yichao Cai # 1, Sambhavi Animesh 1, Ying Zhang 1, Semih Can Akincilar 3, Yan Ping Loh 1, Xinya Li 4, Wee Joo Chng 1 5 6, Vinay Tergaonkar 3 7, Chee Keong Kwoh 2, Melissa J Fullwood 8 9 10 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, 14 Medical

Kar-Tong Tan 1 2 3, Ling-Wen Ding 4, Chan-Shuo Wu 1, Daniel G Tenen 5 6, Henry Yang 5 7 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Biological and Biomedical Sciences Program, Division of Medical Sciences, Harvard Medical

Our bodies constantly encounter oxidants from our diet and metabolism. Oxidative stress is thought to speed up ageing, and increase the risk of diseases like cancer or dementia. However, there

Nisha Padmanabhan 1, Huang Kie Kyon # 1, Arnoud Boot # 2, Kevin Lim 1, Supriya Srivastava 3, Shuwen Chen 4, Zhiyuan Wu 5, Hyung-Ok Lee 6, Vineeth T Mukundan 7, Charlene Chan 7, Yarn Kit Chan 1, Ong Xuewen 1, Jason J Pitt 7, Zul Fazreen Adam Isa 1, Manjie Xing 1, Ming Hui Lee 1, Angie Lay Keng Tan 1, Shamaine Ho Wei Ting 1, Micah

Chong Yang 1, Mitsuhiro Endoh 1 2, Darren Q Tan 1, Ayako Nakamura-Ishizu 1 3, Yuji Takihara 1, Takayoshi Matsumura 1, Toshio Suda 1 4 Affiliations 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 2Department of Pluripotent

Phyllis S Y Chong # 1, Jing Yuan Chooi # 2, Julia S L Lim 2 3, Sabrina Hui Min Toh 3, Tuan Zea Tan 3, Wee-Joo Chng 1 3 4 Affiliations 1Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Gene transcription is controlled largely by transcription factors that bind to enhancers, which are regions of the DNA that loop over to genes to activate them. While silencers have been