Kong LR, Gupta K, Wu AJ, Perera D, Ivanyi-Nagy R, Ahmed SM, Tan TZ, Tan SL, Fuddin A, Sundaramoorthy E, Goh GS, Wong RTX, Costa ASH, Oddy C, Wong H, …

A Glycolytic Metabolite Bypasses “two-hit” Tumor Suppression by BRCA2 (Cell, Apr 2024) Read More »

Over the past short couple of years, artificial intelligence (AI) and deep-learning techniques have revolutionised protein-structure predictions, and as such have accelerated our understanding in corelating biological functions with protein/RNA …

Novel Sequence Searching Algorithm Significantly Boost the Power of AI-based Protein-Protein Complex Structure Prediction Read More »

Joline S J Lim 1, Samuel G W Ow 2, Andrea L A Wong 3, Matilda X W Lee 2, Gloria H J Chan 2, Jia Li Low 2, Raghav Sundar 4, Joan R E Choo 2, Wan Qin Chong 2, Yvonne L E Ang 2, Bee Choo Tai 5, Soo Chin …

Phase II Study of Trifluridine/Tipiracil in Metastatic Breast Cancers with or without Prior Exposure to Fluoropyrimidines (Eur J Cancer, Oct 2023) Read More »

Wei Zheng 1, Qiqige Wuyun 2, Yang Li 1 3, Chengxin Zhang 1, P Lydia Freddolino 4 5, Yang Zhang 6 7 8 9 10 Affiliations 1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. 2Department of Computer Science and Engineering, Michigan State …

Improving Deep Learning Protein Monomer and Complex Structure Prediction using DeepMSA2 with Huge Metagenomics Data (Nature Methods, Jan 2024) Read More »

Kie Kyon Huang 1, Haoran Ma 1, Roxanne Hui Heng Chong 2, Tomoyuki Uchihara 1, Benedict Shi Xiang Lian 1, Feng Zhu 2, Taotao Sheng 3, Supriya Srivastava 2, Su Ting Tay 1, Raghav Sundar 4, Angie Lay Keng Tan 1, Xuewen Ong 1, Minghui Lee 1, Shamaine Wei Ting Ho 3, Tom Lesluyes 5, Hassan Ashktorab 6, Duane Smoot 7, Peter Van Loo 8, Joy …

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression (Cancer Cell, Oct 2023) Read More »