Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) in multiple cancers. Here, we discovered that besides its well-established role in DNA repair, MSH2 exerts a novel epigenomic function in gastric cancer (GC).
Although hypomethylating agents are currently used to treat patients with cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated.
For decades, scientists and doctors have been searching for the mechanisms underlying the formation of cancers. Accumulating studies have revealed that each cancer type (e.g. gastric cancer, lung cancer, leukemia,
Congratulations to A/Prof. Edward Kai-Hua Chow and Dr. Bee Hui Liu, who have recently won awards at the Asian Fund for Cancer Research’s (AFCR) 2021 BRACE Award Venture Competition, a
Joline S J Lim 1, Andrea L A Wong 2, Samuel G W Ow 1, Natalie Y L Ngoi 3, Gloria H J Chan 4, Yvonne L E Ang 5, Wan Qin Chong 6, Siew Eng Lim 4, Yi Wan Lim 6, Matilda Lee 4, Joan R E Choo 7, Hon Lyn
Wei Wen Teo # 1, Xinang Cao # 1 2, Chan-Shuo Wu 1, Hong Kee Tan 1 3, Qiling Zhou 1, Chong Gao 4, Kim Vanuytsel 5 6, Sara S Kumar 5 6, George J Murphy 5 6, Henry Yang 1, Li Chai 7, Daniel G Tenen 8 9 10 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Jian Han 1, Omer An 2, Xi Ren 2, Yangyang Song 2, Sze Jing Tang 2, Haoqing Shen 2, Xinyu Ke 2, Vanessa Hui En Ng 2, Daryl Jin Tai Tay 2, Hui Qing Tan 3, Dennis Kappei 2 4 5, Henry Yang 2, Leilei Chen 6 7 8 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore,
Linear RNA transcripts are the most common type of RNA molecules found in human cells. A subgroup of functional RNA molecules in a circular structure, called circular RNAs (circRNAs), have
Upadhyayula S Srinivas # 1, Norbert S C Tay # 1, Patrick Jaynes # 1, Akshaya Anbuselvan 1, Gokula K Ramachandran 1, Joanna D Wardyn 1, Michal M Hoppe 1, Phuong Mai Hoang 1, Yanfen Peng 1, Sherlly Lim 1, May Yin Lee 2, Praveen C Peethala 1, Omer An 1, Akshay Shendre 1, Bryce W Q Tan 1, Sherlyn Jemimah 1, Manikandan Lakshmanan 3, Longyu Hu 4, Rekha
Malia Alexandra Foo # 1, Mingliang You # 2 3, Shing Leng Chan 1 4, Gautam Sethi 5 6, Glenn K Bonney 4 5, Wei-Peng Yong 1 7, Edward Kai-Hua Chow 1 5 6, Eliza Li Shan Fong 1 8, Lingzhi Wang 9 10 11, Boon-Cher Goh 12 13 14 15 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Hangzhou
