Joline S J Lim 1, Andrea L A Wong 2, Samuel G W Ow 1, Natalie Y L Ngoi 3, Gloria H J Chan 4, Yvonne L E Ang 5, Wan Qin Chong 6, Siew Eng Lim 4, Yi Wan Lim 6, Matilda Lee 4, Joan R E Choo 7, Hon Lyn …

Phase Ib/II Dose Expansion Study of Lenvatinib Combined with Letrozole in Post-Menopausal Women with Hormone Receptor Positive Breast Cancer (Clin Cancer Res, Apr 22) Read More »

Wei Wen Teo # 1, Xinang Cao # 1 2, Chan-Shuo Wu 1, Hong Kee Tan 1 3, Qiling Zhou 1, Chong Gao 4, Kim Vanuytsel 5 6, Sara S Kumar 5 6, George J Murphy 5 6, Henry Yang 1, Li Chai 7, Daniel G Tenen 8 9 10 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. …

Non-Coding RNA LEVER Sequestration of PRC2 Can Mediate Long Range Gene Regulation (Commun Biol, Apr 22) Read More »

Linear RNA transcripts are the most common type of RNA molecules found in human cells. A subgroup of functional RNA molecules in a circular structure, called circular RNAs (circRNAs), have …

CSI Singapore Researchers Uncover Role of ADARs and its Implications in Cancer Development Read More »

Upadhyayula S Srinivas # 1, Norbert S C Tay # 1, Patrick Jaynes # 1, Akshaya Anbuselvan 1, Gokula K Ramachandran 1, Joanna D Wardyn 1, Michal M Hoppe 1, Phuong Mai Hoang 1, Yanfen Peng 1, Sherlly Lim 1, May Yin Lee 2, Praveen C Peethala 1, Omer An 1, Akshay Shendre 1, Bryce W Q Tan 1, Sherlyn Jemimah 1, Manikandan Lakshmanan 3, Longyu Hu 4, Rekha …

PLK1 Inhibition Selectively Induces Apoptosis in ARID1A Deficient Cells Through Uncoupling of Oxygen Consumption from ATP Production. (Oncogene, Mar 22) Read More »

Malia Alexandra Foo # 1, Mingliang You # 2 3, Shing Leng Chan 1 4, Gautam Sethi 5 6, Glenn K Bonney 4 5, Wei-Peng Yong 1 7, Edward Kai-Hua Chow 1 5 6, Eliza Li Shan Fong 1 8, Lingzhi Wang 9 10 11, Boon-Cher Goh 12 13 14 15 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Hangzhou …

Clinical Translation of Patient-Derived Tumour Organoids- Bottlenecks and Strategies. (Biomark Res, Mar 22) Read More »

Haoqing Shen 1 2, Omer An 1, Xi Ren 1, Yangyang Song 1, Sze Jing Tang 1, Xin-Yu Ke 1 2, Jian Han 1, Daryl Jin Tai Tay 1, Vanessa Hui En Ng 1, Fernando Bellido Molias 1, Priyankaa Pitcheshwar 1 2, Ka Wai Leong 1, Ker-Kan Tan 3 4 5, Henry Yang 1, Leilei Chen 6 7 8 Affiliations 1Cancer Science Institute of Singapore, National …

ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022) Read More »

Chromosomal abnormalities are found in most multiple myeloma (MM) patients. While myeloma patients have generally benefited from the advancement of treatment modalities over the years, the treatment outcome for patients …

CSI Singapore Researchers Discover Achilles Heel of High-Risk Multiple Myeloma (MM) Patients Read More »

Yi Xiang See 1, Kaijing Chen 1, Melissa J Fullwood 2 Affiliations 1Nanyang Technological University, Cancer Science Institute of Singapore, National University of Singapore. 2Nanyang Technological University, Cancer Science Institute of Singapore, National University of …

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites. (Genome Res, Feb 2022) Read More »