Maroni G, Bassal MA, Krishnan I, Fhu CW, Savova V, Zilionis R, Maymi VA, Pandell N, Csizmadia E, Zhang J, Storti B, Castaño J, Panella R, Li J, Gustafson CE, […]

Ayako Nakamura-Ishizu 1, Desmond Chin 2, Takayoshi Matsumura 2, Darren Qiancheng Tan 2, Makiko Kashio Mochizuki 1, Deng Jianwen 2, Toshio Suda 3 1Tokyo women’s medical univeristy, Tokyo, Japan. 2National University of Singapore, Singapore, Singapore. 3Kumamoto Univerisity IRCMS, Japan. Abstract Hematopoietic stem cells

Michal M Hoppe 1, Patrick Jaynes 1, Joanna D Wardyn 1, Sai Srinivas Upadhyayula 1, Tuan Zea Tan 1, Stefanus Lie 1, Diana G Z Lim 2, Brendan N K Pang 1 2, Sherlly Lim 1, Joe P S Yeong 1, Anthony Karnezis 3, Derek S Chiu 3, Samuel Leung 3, David G Huntsman 3, Anna S Sedukhina 4, Ko Sato 4, Monique

The pathways that control the behaviour of cells are complex, non-linear and highly redundant. As such, identifying the right molecular target for the development of next-generation drugs is oftentimes akin

ATP-hydrolyzing enzymes like protein kinases are major drug targets for oncology. Drugs that inhibit these enzymes typically engage their ATP-binding (active) sites to inhibit catalysis. However, these active sites are

Credit: National University Cancer Institute, Singapore (NCIS) CSI Principal Investigator, Dr. Anand Jeyasekharan, wasrecently involved in a pioneering study performed by the Icahn School of Medicine at Mount Sinai in

Hematopoietic stem cells (HSC) residing in the bone marrow are essential for life-long hematopoiesis. To ensure long term regenerative potential in HSCs, the preservation of HSCs in its quiescent state