Super-enhancer-driven TOX2 Mediates Oncogenesis in Natural Killer/T Cell Lymphoma (Mol Cancer., Apr 2023)
Zhou J, Toh SH, Tan TK, Balan K, Lim JQ, Tan TZ, Xiong S, Jia Y, Ng SB, Peng Y, Jeyasekharan AD, Fan S, Lim ST, Ong CJ, Ong CK, […]
Research
Comprehensive Molecular Phenotyping Of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities (Gut, Mar 2023)
Xu C, Huang KK, Law JH, Chua JS, Sheng T, Flores NM, Pizzi MP, Okabe A, Tan ALK, Zhu F, Kumar V, Lu X, Benitez AM, Lian BSX, Ma H,
Novel Role of RNA Editing by ADAR2 in Core Binding Factor Acute Myelogenous Leukemias
A team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore, co-led by Professor Daniel G. Tenen and Associate Professor Polly Chen Leilei, has for
Novel Role of RNA Editing by ADAR2 in Core Binding Factor Acute Myelogenous Leukemias Read More »
[Meta-Analysis] A Pooled Analysis of Outcomes According to Cytogenetic Abnormalities in Patients Receiving Ixazomib- vs Placebo-based Therapy for Multiple Myeloma (Blood Cancer J., Jan 23)
Wee-Joo Chng 1 2, Sagar Lonial 3, Gareth J Morgan 4, Shinsuke Iida 5, Philippe Moreau 6, Shaji K Kumar 7, Philip Twumasi-Ankrah 8, Miguel Villarreal 8, Ajeeta B Dash 8, Alexander Vorog 8, Xiaoquan Zhang 8, Kaveri Suryanarayan 8, Richard Labotka 8, Meletios A Dimopoulos 9, S Vincent Rajkumar 7 Affiliations 1Department of Hematology-Oncology, National University Cancer Institute, Singapore,
[Meta-Analysis] FAM3C in Circulating Tumor-derived Extracellular Vesicles Promotes Non-small Cell Lung Cancer Growth in Secondary Sites (Theranostics, Jan 23)
Win Lwin Thuya 1, Li Ren Kong 1 2 3, Nicholas L Syn 1 4, Ling-Wen Ding 1 5, Esther Sok Hwee Cheow 1, Regina Tong Xin Wong 1, Tingting Wang 1, Robby Miguel Wen-Jing Goh 1, Hongyan Song 1, Migara K Jayasinghe 2, Minh Tn Le 2 3, Jian Cheng Hu 3, Wei-Peng Yong 1 3 6, Soo-Chin Lee 1 3 6, Andrea Li-Ann Wong 1 3 6, Gautam Sethi 2 3, Huynh
De Novo Protein Fold Design Through Sequence-independent Fragment Assembly Simulations (Proc. Natl. Acad. Sci. U S A, Jan 23)
Robin Pearce 1, Xiaoqiang Huang 1, Gilbert S Omenn 1 2 3 4, Yang Zhang 1 5 6 7 Affiliations 1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109. 2Department of Internal Medicine, University of Michigan, Ann Arbor, MI
A Myb Enhancer-guided Analysis of Basophil and Mast Cell Differentiation (Nat Commun, Nov 22)
Takayoshi Matsumura 1 2 3, Haruhito Totani 4, Yoshitaka Gunji 5, Masahiro Fukuda 6 7, Rui Yokomori 4, Jianwen Deng 4, Malini Rethnam 4, Chong Yang 4, Tze King Tan 4, Tadayoshi Karasawa 5, Kazuomi Kario 8, Masafumi Takahashi 5, Motomi Osato 4, Takaomi Sanda 4 9, Toshio Suda 10 11 12 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. csitkm@nus.edu.sg.
Analysis of Clinically Relevant Variants from Ancestrally Diverse Asian Genomes (Nat Commun, Nov 22)
Sock Hoai Chan # 1 2 3, Yasmin Bylstra # 4, Jing Xian Teo 4, Jyn Ling Kuan 4, Nicolas Bertin 5, Mar Gonzalez-Porta 5, Maxime Hebrard 5, Roberto Tirado-Magallanes 5, Joanna Hui Juan Tan 5, Justin Jeyakani 5, Zhihui Li 5, Jin Fang Chai 6, Yap Seng Chong 7 8, Sonia Davila 4 9 10, Liuh Ling Goh 11, Eng Sing Lee 3 12, Eleanor Wong 13, Tien Yin Wong 14; SG10K_Health Consortium; Shyam
Nuclear pCHK1 as a Potential Biomarker of Increased Sensitivity to ATR Inhibition (J Pathol, Nov 22)
Vignesh Sundararajan 1, Tuan Zea Tan 1 2, Diana Lim 3, Yanfen Peng 1, Antje Margret Wengner 4, Natalie Yan Li Ngoi 5, Anand D Jeyasekharan 1, David Shao Peng Tan 1 5 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Genomics and
Requirement for TP73 and Genetic Alterations Originating from its Intragenic Super-enhancer in Adult T-cell Leukemia (Leukemia, Sep 2022)
Jolynn Zu Lin Ong # 1, Rui Yokomori # 1, Regina Wan Ju Wong 1, Tze King Tan 1, Ryuzo Ueda 2, Takashi Ishida 3, Shinsuke Iida 4, Takaomi Sanda 5 6 Affiliations 1Cancer Science Institute of Singapore, National University of, Singapore, 117599, Singapore. 2Department of Tumor Immunology,