Sock Hoai Chan # 1 2 3, Yasmin Bylstra # 4, Jing Xian Teo 4, Jyn Ling Kuan 4, Nicolas Bertin 5, Mar Gonzalez-Porta 5, Maxime Hebrard 5, Roberto Tirado-Magallanes 5, Joanna Hui Juan Tan 5, Justin Jeyakani 5, Zhihui Li 5, Jin Fang Chai 6, Yap Seng Chong 7 8, Sonia Davila 4 9 10, Liuh Ling Goh 11, Eng Sing Lee 3 12, Eleanor Wong 13, Tien Yin Wong 14; SG10K_Health Consortium; Shyam …

Analysis of Clinically Relevant Variants from Ancestrally Diverse Asian Genomes (Nat Commun, Nov 22) Read More »

Vignesh Sundararajan 1, Tuan Zea Tan 1 2, Diana Lim 3, Yanfen Peng 1, Antje Margret Wengner 4, Natalie Yan Li Ngoi 5, Anand D Jeyasekharan 1, David Shao Peng Tan 1 5 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Genomics and …

Nuclear pCHK1 as a Potential Biomarker of Increased Sensitivity to ATR Inhibition (J Pathol, Nov 22) Read More »

Jolynn Zu Lin Ong # 1, Rui Yokomori # 1, Regina Wan Ju Wong 1, Tze King Tan 1, Ryuzo Ueda 2, Takashi Ishida 3, Shinsuke Iida 4, Takaomi Sanda 5 6 Affiliations 1Cancer Science Institute of Singapore, National University of, Singapore, 117599, Singapore. 2Department of Tumor Immunology, …

Requirement for TP73 and Genetic Alterations Originating from its Intragenic Super-enhancer in Adult T-cell Leukemia (Leukemia, Sep 2022) Read More »

Jasmine Goh 1, Sanjay De Mel 2 3, Michal M Hoppe 1, Masturah Bte Mohd Abdul Rashid 4, Xi Yun Zhang 1, Patrick Jaynes 1, Esther Ka Yan Ng 1, Nur’Atiqa Diana Binti Rahmat 1, Jayalakshmi 1, Clementine Xin Liu 3, Limei Poon 2 3, Esther Chan 2 3, Joanne Lee 2 3, Yen Lin Chee 2 3, Liang Piu Koh 3, Lip Kun Tan 5, Teck …

An ex vivo Platform to Guide Drug Combination Treatment in Relapsed/Refractory Lymphoma (Sci Transl Med, Oct 2022) Read More »

Chong Yang 1, Rui Yokomori 1, Lee Hui Chua 1, Shi Hao Tan 1, Darren Qiancheng Tan 1, Kenichi Miharada 2, Takaomi Sanda 1, Toshio Suda 1 2 Affiliations 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. …

Mitochondria Transfer Mediates Stress Erythropoiesis by Altering the Bioenergetic Profiles of early Erythroblasts through CD47 (J Exp Med, Sep 2022) Read More »

With lowering costs of sequencing and genetic profiling techniques, genetic drivers can now be detected readily in tumors but current prognostic models for Natural-killer/T cell lymphoma (NKTCL) have yet to fully leverage on them for prognosticating patients.

PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the most important mechanisms in mitochondrial quality control (MQC) via the clearance of damaged mitochondria.

SETDB1 is a key regulator of lineage-specific genes and endogenous retroviral elements (ERVs) through its deposition of repressive H3K9me3 mark.

According to GLOBOCAN, gastric cancer (GC) is a significant cause of cancer mortality worldwide, with over 700,000 deaths attributable to it annually. Mesenchymal-subtype gastric cancer (Mes-GC) is a particularly aggressive …

Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities (Gut, Jul 2022) Read More »

The peritoneum is a common site of metastasis in advanced gastric cancer (GC). Diagnostic laparoscopy is now routinely performed as part of disease staging, leading to an earlier diagnosis of synchronous peritoneal metastasis (PM).