Kazuto Suda 1, Atsushi Okabe 2, Junichi Matsuo 1, Linda Shyue Huey Chuang 1, Ying Li 1, Nawaphat Jangphattananont 1, Naing Naing Mon 1, Khine Nyein Myint 1, Akihiro Yamamura 1, Jimmy Bok-Yan So 3, Dominic Chih-Cheng Voon 4, Henry Yang 1, Khay Guan Yeoh 5 6, Atsushi Kaneda 2, Yoshiaki Ito 1 Affiliations 1Cancer Science Institute of Singapore, National …

Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer (Cancer Research Communications – AACR Journals, Jan 2024) Read More »

Kong LR, Gupta K, Wu AJ, Perera D, Ivanyi-Nagy R, Ahmed SM, Tan TZ, Tan SL, Fuddin A, Sundaramoorthy E, Goh GS, Wong RTX, Costa ASH, Oddy C, Wong H, …

A Glycolytic Metabolite Bypasses “two-hit” Tumor Suppression by BRCA2 (Cell, Apr 2024) Read More »

Over the past short couple of years, artificial intelligence (AI) and deep-learning techniques have revolutionised protein-structure predictions, and as such have accelerated our understanding in corelating biological functions with protein/RNA …

Novel Sequence Searching Algorithm Significantly Boost the Power of AI-based Protein-Protein Complex Structure Prediction Read More »

Joline S J Lim 1, Samuel G W Ow 2, Andrea L A Wong 3, Matilda X W Lee 2, Gloria H J Chan 2, Jia Li Low 2, Raghav Sundar 4, Joan R E Choo 2, Wan Qin Chong 2, Yvonne L E Ang 2, Bee Choo Tai 5, Soo Chin …

Phase II Study of Trifluridine/Tipiracil in Metastatic Breast Cancers with or without Prior Exposure to Fluoropyrimidines (Eur J Cancer, Oct 2023) Read More »

Wei Zheng 1, Qiqige Wuyun 2, Yang Li 1 3, Chengxin Zhang 1, P Lydia Freddolino 4 5, Yang Zhang 6 7 8 9 10 Affiliations 1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. 2Department of Computer Science and Engineering, Michigan State …

Improving Deep Learning Protein Monomer and Complex Structure Prediction using DeepMSA2 with Huge Metagenomics Data (Nature Methods, Jan 2024) Read More »

Kie Kyon Huang 1, Haoran Ma 1, Roxanne Hui Heng Chong 2, Tomoyuki Uchihara 1, Benedict Shi Xiang Lian 1, Feng Zhu 2, Taotao Sheng 3, Supriya Srivastava 2, Su Ting Tay 1, Raghav Sundar 4, Angie Lay Keng Tan 1, Xuewen Ong 1, Minghui Lee 1, Shamaine Wei Ting Ho 3, Tom Lesluyes 5, Hassan Ashktorab 6, Duane Smoot 7, Peter Van Loo 8, Joy …

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression (Cancer Cell, Oct 2023) Read More »

Wei Wang 1, Mingqin Li 2, Lingzhi Wang 3, Lu Chen 4, Boon-Cher Goh 5 Affiliations 1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. 2Department of Medical …

Curcumin in Cancer Therapy: Exploring Molecular Mechanisms and Overcoming Clinical Challenges (Cancer Lett., Aug 2023) Read More »

Shi Hao Tan 1, Tze King Tan 1, Rui Yokomori 1, Minghui Liao 1, Xiao Zi Huang 1, Allen Eng Juh Yeoh 2 3, Takaomi Sanda 4 5 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 2Cancer Science Institute of …

TAL1 Hijacks MYCN Enhancer That Induces MYCN Expression And Dependence On Mevalonate Pathway In T-Cell Acute Lymphoblastic Leukemia (Leukemia, Aug 2023) Read More »

Phyllis S Y Chong 1 2, Jing-Yuan Chooi 1, Julia S L Lim 1 2, Aaron C Y Leow 2, Sabrina Hui Min Toh 2, Irfan Azaman 2, Mun Yee Koh 1, Phaik Ju Teoh 1 2, Tuan Zea Tan 2, Tae-Hoon Chung 2, Wee Joo Chng 12 Affiliations 1Yong Loo Lin School of …

Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma (Cancer Res., Jul 2023) Read More »

Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Gao Q, Flint TR, Young L, Connell CM, Lukey MJ, Goncalves MD, White EP, Venkitaraman AR, …

Ketogenic Diet Promotes Tumor Ferroptosis but Induces Relative Corticosterone Deficiency that Accelerates Cachexia (Cell Metab., Jun 2023) Read More »