Research

“3G” Trial: An RNA Editing Signature to Guide Gastric Cancer Chemotherapy. (Cancer Res, Feb 2021)

Omer An 1, Yangyang Song 1, Xinyu Ke 1, Jimmy Bok-Yan So 2, Raghav Sundar 3, Henry Yang 1, Sun Young Rha 4, Ming Hui Lee 5, Su Ting Tay 6, Xuewen Ong 7, Angie Lay Keng Tan 5, Matthew Chau Hsien Ng 8, Erwin Tantoso 9, Leilei Chen 10, Patrick Tan 11, Wei Peng Yong 12, Singapore Gastric Cancer Consortium 13 Author …

“3G” Trial: An RNA Editing Signature to Guide Gastric Cancer Chemotherapy. (Cancer Res, Feb 2021) Read More »

H3K27me3-rich Genomic Regions Can Function as Silencers to Repress Gene Expression via Chromatin Interactions. (Nat Commun, Jan 2021)

Yichao Cai # 1 2, Ying Zhang # 1, Yan Ping Loh 1, Jia Qi Tng 1, Mei Chee Lim 1 3, Zhendong Cao 1 4, Anandhkumar Raju 5, Erez Lieberman Aiden 6, Shang Li 3 7, Lakshmanan Manikandan 5, Vinay Tergaonkar 5, Greg Tucker-Kellogg 8 9, Melissa Jane Fullwood 10 11 12 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, …

H3K27me3-rich Genomic Regions Can Function as Silencers to Repress Gene Expression via Chromatin Interactions. (Nat Commun, Jan 2021) Read More »

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma. (Oncogene, Feb 2021)

Xin-Yu Ke 1 2, Ye Chen 3, Valarie Yu-Yan Tham 1, Ruby Yu-Tong Lin 1, Pushkar Dakle 1, Kassoum Nacro 4, Mark Edward Puhaindran 5 6 7, Peter Houghton 8, Angela Pang 5, Victor Kwanmin Lee 9, Ling-Wen Ding 10, Sigal Gery 11, Jeffrey Hill 12, Leilei Chen 1 2, Liang Xu 13, H Phillip Koeffler 1 5 11 Author Information 1Cancer Science Institute of Singapore, National …

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma. (Oncogene, Feb 2021) Read More »

ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function. (Nat Commun, Jan 2021)

Qiling Zhou 1 2, Miao Yu 3, Roberto Tirado-Magallanes 1, Bin Li 4, Lingshi Kong 1, Mingrui Guo 1 2, Zi Hui Tan 1, Sanghoon Lee 1 5, Li Chai 6, Akihiko Numata 1 7, Touati Benoukraf 1 8, Melissa Jane Fullwood 1 9 10, Motomi Osato 1, Bing Ren 4 11, Daniel G Tenen 12 13 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, …

ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function. (Nat Commun, Jan 2021) Read More »

Capitalizing on Synthetic Lethality of MYC to Treat Cancer in the Digital Age. (Trends Pharmacol Sci, Jan 2021)

Dexter Kai Hao Thng 1, Tan Boon Toh 2, Edward Kai-Hua Chow 3 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore. 2The N.1 Institute for Health, National University of Singapore, Singapore; …

Capitalizing on Synthetic Lethality of MYC to Treat Cancer in the Digital Age. (Trends Pharmacol Sci, Jan 2021) Read More »

Short H2A histone variants are expressed in cancer. (Nat Commun, Jan 2021)

Guo-Liang Chew 1, Marie Bleakley 2, Robert K Bradley 3 4 5, Harmit S Malik 4 6, Steven Henikoff 4 6, Antoine Molaro 7 8, Jay Sarthy 9 Author Information 1The Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Clinical Research Division, Fred Hutchinson Cancer …

Short H2A histone variants are expressed in cancer. (Nat Commun, Jan 2021) Read More »

EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. (Nat Commun, Nov 2020)

Yi Bao 1 2, Gokce Oguz 2, Wee Chyan Lee 2, Puay Leng Lee 2, Kakaly Ghosh 2, Jiayao Li 3, Panpan Wang 3, Peter E Lobie 1 4, Sidse Ehmsen 5, Henrik J Ditzel 5 6, Andrea Wong 7, Ern Yu Tan 8, Soo Chin Lee 9 10, Qiang Yu 11 12 13 Author Information 1Cancer Science Institute of Singapore, Yong Loo …

EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. (Nat Commun, Nov 2020) Read More »

The double-edged sword of H19 lncRNA: Insights into cancer therapy (Cancer Lett, Nov 2020)

Yun Wei Shermane Lim 1, Xiaoqiang Xiang 2, Manoj Garg 3, Minh Tn Le 4, Andrea Li-Ann Wong 5, Lingzhi Wang 6, Boon-Cher Goh 7 Author Information 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore; Institute for Digital Medicine …

The double-edged sword of H19 lncRNA: Insights into cancer therapy (Cancer Lett, Nov 2020) Read More »

Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair. (Gut, Dec 2020)

Junichi Matsuo 1, Daisuke Douchi 1 2, Khine Myint 1, Naing Naing Mon 1, Akihiro Yamamura 1 2, Kazuyoshi Kohu 1, Dede Liana Heng 1, Sabirah Chen 1, Nur Astiana Mawan 1, Napat Nuttonmanit 1, Ying Li 1, Supriya Srivastava 3, Shamaine Wei Ting Ho 1 4, Nicole Yee Shin Lee 5, Hong Kai Lee 5, Makoto Adachi 6, Atsushi Tamura 7 8 9, Jinmiao Chen 5, Henry Yang 1, Ming Teh 10, Jimmy Bok-Yan …

Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair. (Gut, Dec 2020) Read More »