2022
Congratulations to Ms. Xu Jingru, a CSI PhD student on receiving the Materials Research Society (MRS) 2022 NM05 Symposium Best Student Oral Presentation Award!
Held in Honolulu, Hawaii between May 8 – 13, Ms. Xu Jingru presented at the NM05 Symposium, which focuses on discussions relating to the recent advances of nanodiamond in quantum sensing, diagnostic, biomedical and other novel applications.
Hepatocellular Carcinoma Organoid Co-cultures Mimic Angiocrine Crosstalk to Generate Inflammatory Tumor Microenvironment (Biomaterials, May 22)
Despite approvals of several therapeutics to treat advanced HCC in the past few years, the impact of anti-angiogenic treatment on HCC patient overall survival remains limited. This suggests there may be alternative, perfusion-independent roles of endothelial cells that support tumor progression.
Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer (Cancer Res, May 22)
Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) in multiple cancers. Here, we discovered that besides its well-established role in DNA repair, MSH2 exerts a novel epigenomic function in gastric cancer (GC).
Demethylation and Up-regulation of an Oncogene After Hypomethylating Therapy (N Engl J Med, May 22)
Although hypomethylating agents are currently used to treat patients with cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated.
“Cancer fishing”: CSI Singapore Researchers Discover New Mechanisms of Cancer using Zebrafish and Single-cell Sequencing Technology
For decades, scientists and doctors have been searching for the mechanisms underlying the formation of cancers. Accumulating studies have revealed that each cancer type (e.g. gastric cancer, lung cancer, leukemia,