2022

Stromal reprogramming through dual PDGFR?/? blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors [Cancer Res, Dec 2022]

In collaboration with CSI Singapore’s Prof. Patrick Tan, a group of researchers investigated the mechanisms by which the stroma manipulates the immune microenvironment and facilitates cancer progression and immune evasion. …

Stromal reprogramming through dual PDGFR?/? blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors [Cancer Res, Dec 2022] Read More »

Deciphering Colorectal Cancer Genetics through Multi-omic Analysis of 100,204 Cases and 154,587 Controls of European and East Asian Ancestries [Nat Genet, Dec 2022]

In collaboration with CSI Singapore’s Prof. Lee Soo Chin, a group of researchers conducted a genome-wide association study meta-analysis of 100,204 colorectal cancer (CRC) cases and 154,587 controls of European …

Deciphering Colorectal Cancer Genetics through Multi-omic Analysis of 100,204 Cases and 154,587 Controls of European and East Asian Ancestries [Nat Genet, Dec 2022] Read More »

Real-world outcomes from use of CDK4/6 inhibitors in the management of advanced/metastatic breast cancer in Asia [Ther Adv Med Oncol, Dec 2022]

A group of researchers, led by CSI Singapore’s Prof. Lee Soo Chin, evaluated the clinical outcomes for combinations of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) with anti-oestrogen therapy for treatment of …

Real-world outcomes from use of CDK4/6 inhibitors in the management of advanced/metastatic breast cancer in Asia [Ther Adv Med Oncol, Dec 2022] Read More »

A Myb Enhancer-guided Analysis of Basophil and Mast Cell Differentiation (Nat Commun, Nov 22)

Takayoshi Matsumura 1 2 3, Haruhito Totani 4, Yoshitaka Gunji 5, Masahiro Fukuda 6 7, Rui Yokomori 4, Jianwen Deng 4, Malini Rethnam 4, Chong Yang 4, Tze King Tan 4, Tadayoshi Karasawa 5, Kazuomi Kario 8, Masafumi Takahashi 5, Motomi Osato 4, Takaomi Sanda 4 9, Toshio Suda 10 11 12 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. csitkm@nus.edu.sg. …

A Myb Enhancer-guided Analysis of Basophil and Mast Cell Differentiation (Nat Commun, Nov 22) Read More »

Analysis of Clinically Relevant Variants from Ancestrally Diverse Asian Genomes (Nat Commun, Nov 22)

Sock Hoai Chan # 1 2 3, Yasmin Bylstra # 4, Jing Xian Teo 4, Jyn Ling Kuan 4, Nicolas Bertin 5, Mar Gonzalez-Porta 5, Maxime Hebrard 5, Roberto Tirado-Magallanes 5, Joanna Hui Juan Tan 5, Justin Jeyakani 5, Zhihui Li 5, Jin Fang Chai 6, Yap Seng Chong 7 8, Sonia Davila 4 9 10, Liuh Ling Goh 11, Eng Sing Lee 3 12, Eleanor Wong 13, Tien Yin Wong 14; SG10K_Health Consortium; Shyam …

Analysis of Clinically Relevant Variants from Ancestrally Diverse Asian Genomes (Nat Commun, Nov 22) Read More »

Nuclear pCHK1 as a Potential Biomarker of Increased Sensitivity to ATR Inhibition (J Pathol, Nov 22)

Vignesh Sundararajan 1, Tuan Zea Tan 1 2, Diana Lim 3, Yanfen Peng 1, Antje Margret Wengner 4, Natalie Yan Li Ngoi 5, Anand D Jeyasekharan 1, David Shao Peng Tan 1 5 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Genomics and …

Nuclear pCHK1 as a Potential Biomarker of Increased Sensitivity to ATR Inhibition (J Pathol, Nov 22) Read More »

Requirement for TP73 and Genetic Alterations Originating from its Intragenic Super-enhancer in Adult T-cell Leukemia (Leukemia, Sep 2022)

Jolynn Zu Lin Ong # 1, Rui Yokomori # 1, Regina Wan Ju Wong 1, Tze King Tan 1, Ryuzo Ueda 2, Takashi Ishida 3, Shinsuke Iida 4, Takaomi Sanda 5 6 Affiliations 1Cancer Science Institute of Singapore, National University of, Singapore, 117599, Singapore. 2Department of Tumor Immunology, …

Requirement for TP73 and Genetic Alterations Originating from its Intragenic Super-enhancer in Adult T-cell Leukemia (Leukemia, Sep 2022) Read More »

An ex vivo Platform to Guide Drug Combination Treatment in Relapsed/Refractory Lymphoma (Sci Transl Med, Oct 2022)

Jasmine Goh 1, Sanjay De Mel 2 3, Michal M Hoppe 1, Masturah Bte Mohd Abdul Rashid 4, Xi Yun Zhang 1, Patrick Jaynes 1, Esther Ka Yan Ng 1, Nur’Atiqa Diana Binti Rahmat 1, Jayalakshmi 1, Clementine Xin Liu 3, Limei Poon 2 3, Esther Chan 2 3, Joanne Lee 2 3, Yen Lin Chee 2 3, Liang Piu Koh 3, Lip Kun Tan 5, Teck …

An ex vivo Platform to Guide Drug Combination Treatment in Relapsed/Refractory Lymphoma (Sci Transl Med, Oct 2022) Read More »

Mitochondria Transfer Mediates Stress Erythropoiesis by Altering the Bioenergetic Profiles of early Erythroblasts through CD47 (J Exp Med, Sep 2022)

Chong Yang 1, Rui Yokomori 1, Lee Hui Chua 1, Shi Hao Tan 1, Darren Qiancheng Tan 1, Kenichi Miharada 2, Takaomi Sanda 1, Toshio Suda 1 2 Affiliations 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. …

Mitochondria Transfer Mediates Stress Erythropoiesis by Altering the Bioenergetic Profiles of early Erythroblasts through CD47 (J Exp Med, Sep 2022) Read More »