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June 27, 2022

CSI Singapore Researchers Discover Promising Novel Drug Combination for Controlling Metastatic Breast Cancer

A team of researchers led by Professor Lee Soo Chin, Head and Senior Consultant, Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS), and Senior Principal Investigator at Cancer Science...

June 21, 2022

CSI Singapore Principal Investigators Part of a Collaborative Effort to Secure a $25M NMRC Collaborative Grant to Tackle Liver Cancer

CSI Singapore would like to congratulate its Principal Investigators, namely Prof. Patrick Tan, Assoc. Prof. Edward Chow and Dr. Tam Wai Leong who are involved in a collaborative effort with...

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Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer (Cell Metabolism Nov 2025)

Authors Zhengwei Wu , Zhenxun Wang , Seow Qi Ng , Jessica Alice Lidster , Paul Schwerd-Kleine , Zi Jin Cheryl Phua , Kai Lay Esther Peh , Yin Ying […]

Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone (JCI, July 2025)

Authors: Valeria Cancila, Giorgio Bertolazzi, Allison S.Y. Chan, Giovanni Medico, Giulia Bastianello, Gaia Morello, Daniel Paysan, Clemence Lai, Liang Hong, Girija Shenoy, Patrick W. Jaynes, Giovanna Schiavoni, Fabrizio Mattei, Silvia […]

Prospective Clinical Validation of a Combinatorial Functional Precision Medicine Platform in Relapsed/Refractory Non-Hodgkin’s Lymphoma (JCO Precision Oncology, September 2025)

Treating patients whose non-Hodgkin’s lymphoma (NHL) has come back or stopped responding to therapy remains very difficult. Many eventually run out of standard treatment options. A team led by Dr. […]

🚨 New Milestone in Cancer Research and Precision Medicine 🚨

CSI Singapore and Next&Bio Launch Joint Organoid Research Laboratory at NUS We are excited to announce the launch of a joint organoid research laboratory by Next&Bio and the Cancer Science […]

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability (Molecular Cell 2025)

Michael A. Longo1 ∙ Syed Moiz Ahmed2,10 ∙ Yue Chen3,10 ∙ Chi-Lin Tsai1,10 ∙ Sarita Namjoshi1 ∙ Runze Shen1 ∙ Zamal Ahmed1 ∙ Xiaoyan Wang1 ∙ Rajika L. Perera4 ∙ […]

A Multi-task Domain-adapted Model to Predict Chemotherapy Response from Mutations in Recurrently Altered Cancer Genes (iScience, March 2025)

Aishwarya Jayagopal1, 7 ∙ Robert J. Walsh2,7 ∙ Krishna Kumar Hariprasannan1 ∙ Ragunathan Mariappan1 ∙ Debabrata Mahapatra6 ∙ Patrick William Jaynes3 ∙ Diana Lim4 ∙ David Shao Peng Tan2,3,5 ∙ Tuan Zea Tan3 ∙ Jason J. Pitt3 ∙ Anand D. Jeyasekharan2,3 Vaibhav Rajan1, 8 1. Department of Information Systems and Analytics, School of Computing, National University of Singapore, Singapore 117417, Singapore […]

The ADAR1-Regulated Cytoplasmic dsRNA-Sensing Pathway is A Novel Mechanism of Lenalidomide Resistance in Multiple Myeloma (Blood, March 2025)

Mun Yee Koh 1, Tae-Hoon Chung 1, Nicole Xin Ning Tang 1, Sabrina Hui Min Toh 1, Jianbiao Zhou 1, Tze King Tan 1, Leilei Chen 1,2, Wee Joo Chng […]

Pembrolizumab With or Without Bevacizumab in Platinum-Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Randomized, Open-Label, Phase 2 Trial (The Lancet Oncology, Feb 2025)

Wan-Qin Chong, MBBS a ∙ Jia-Li Low, MBBS a ∙ Joshua K Tay, PhD b,d ∙ Thi Bich Uyen Le, BSca ∙ Grace Shi-Qing Goh, BSc g ∙ Kenneth Sooi, MBBS a ∙ Hui-Lin Teo, MBBS h ∙ Seng-Wee Cheo, MD a ∙ Regina Tong-Xin Wong, BSc g ∙ Jens Samol, MD h,j,k ∙ Ming-Yann Lim, MBBS i ∙ Hao Li, MBBS i ∙ Niranjan Shirgaonkar, MSc l ∙ Shumei Chia, PhD l ∙ Lingzhi Wang, PhD f,g ∙ Anil Gopinathan, MBBS c ∙ Donovan Kum-Chuen Eu, MBBS b ∙ Raymond King-Yin Tsang, MBChB b,d ∙ Prof Kwok-Seng Loh, MBBS b,d ∙ Prof Han-Chong Toh, MBBS m ∙ Nicholas Syn, MBBSe ∙ Li-Ren Kong, PhD f,g ∙ Ramanuj Dasgupta, PhD l ∙ Bee-Choo Tai, PhD n ∙ Yaw-Chyn Lim, PhD […]

Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia (Leukemia, Nov 2024)

Xiaoman Shao # 1, Rui Yokomori # 1, Jolynn Zu Lin Ong 1, Haoqing Shen 1, Dennis Kappei 1 2 3, Leilei Chen 1 3, Allen Eng Juh Yeoh 1 3 4, Shi Hao Tan 1, Takaomi Sanda 5 6 7 8 Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. Department of Biochemistry, […]

ZBTB48 is a Priming Factor Regulating B-Cell-Specific CIITA Expression (The EMBO Journal, Dec 2024, Cover story)

Grishma Rane 1, Vivian L S Kuan 1, Suman Wang 2, Michelle Meng Huang Mok 1, Vartika Khanchandani 1, Julia Hansen 1, Ieva Norvaisaite 1, Naasyidah Zulkaflee 1, Wai Khang Yong 1, Arne Jahn 3 4 5 6, Vineeth T Mukundan 1, Yunyu Shi 2, Motomi Osato 1, Fudong Li 2, Dennis Kappei 7 8 9 Affiliations 1Cancer Science Institute of Singapore, National University […]

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