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January 10, 2023
Deciphering Colorectal Cancer Genetics through Multi-omic Analysis of 100,204 Cases and 154,587 Controls of European and East Asian Ancestries [Nat Genet, Dec 2022]
In collaboration with CSI Singapore’s Prof. Lee Soo Chin, a group of researchers conducted a genome-wide association study meta-analysis of 100,204 colorectal cancer (CRC) cases and 154,587 controls of European...
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January 10, 2023
Real-world outcomes from use of CDK4/6 inhibitors in the management of advanced/metastatic breast cancer in Asia [Ther Adv Med Oncol, Dec 2022]
A group of researchers, led by CSI Singapore’s Prof. Lee Soo Chin, evaluated the clinical outcomes for combinations of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) with anti-oestrogen therapy for treatment of...
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Press Release

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qChIP-MS reveals the local chromatin composition by label-free quantitative proteomics

Researchers led by Principal Investigator, Assistant Professor Dennis Kappei, have developed a new method that allows scientists to better understand how DNA activity is organised and regulated inside our cells. […]

An Analytic Framework Characterizes the Biological Processes That Shape Copy Number–Based Genome Instability Patterns in Breast Cancer

 A study led by Principal Investigator, Dr. Jason Pitt, has identified eight new “signatures” of DNA patterns (gains and/or losses) in breast cancer. By analysing nearly 2,800 genomes, the team […]

A Paired Sequence Language Model for Protein-Protein Interaction Modeling

Researchers led by Senior Principal Investigator, Professor Zhang Yang, have developed a new artificial intelligence (AI) model that can more accurately predict how proteins interact with one another—an advance that […]

Learned Conformational Space and Pharmacophore into Molecular Foundational Model

A key challenge in AI-driven drug discovery is moving beyond molecular analysis to enable chemically meaningful molecular design. In a newly published study in Advanced Science, researchers led by Senior […]

Pembrolizumab Plus Lenvatinib in Recurrent Gynaecological Clear Cell Carcinoma (LARA): A Multicentre, Single-Arm, Phase 2 Trial (The LANCET Oncology, Feb 2026)

A multinational study led by Principal Investigator A/Prof. David Tan and collaborators from Singapore and South Korea has demonstrated encouraging results for patients with recurrent clear cell ovarian and endometrial […]

Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer (Cell Metabolism Nov 2025)

Authors Zhengwei Wu , Zhenxun Wang , Seow Qi Ng , Jessica Alice Lidster , Paul Schwerd-Kleine , Zi Jin Cheryl Phua , Kai Lay Esther Peh , Yin Ying […]

Pragmatic Interventions to Boost Surveillance Mammogram Uptake Among an Overdue Population A Randomized Clinical Trial (JAMA Internal Medicine, Nov 2025)

Authors Soo-Chin Lee, Sasidharan Swarnalatha Lucky, Junxian Zhu, Samuel Ow, Lukas Loh, Jun Hui Tan, Siew Eng Lim, Zarinah Hairom, Shivan Mehta 6, Bee-Choo Tai, Boon-Cher Goh Abstract Led by […]

Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone (JCI, July 2025)

Authors: Valeria Cancila, Giorgio Bertolazzi, Allison S.Y. Chan, Giovanni Medico, Giulia Bastianello, Gaia Morello, Daniel Paysan, Clemence Lai, Liang Hong, Girija Shenoy, Patrick W. Jaynes, Giovanna Schiavoni, Fabrizio Mattei, Silvia […]

Prospective Clinical Validation of a Combinatorial Functional Precision Medicine Platform in Relapsed/Refractory Non-Hodgkin’s Lymphoma (JCO Precision Oncology, September 2025)

Treating patients whose non-Hodgkin’s lymphoma (NHL) has come back or stopped responding to therapy remains very difficult. Many eventually run out of standard treatment options. A team led by Dr. […]

🚨 New Milestone in Cancer Research and Precision Medicine 🚨

CSI Singapore and Next&Bio Launch Joint Organoid Research Laboratory at NUS We are excited to announce the launch of a joint organoid research laboratory by Next&Bio and the Cancer Science […]

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