In collaboration with CSI Singapore’s Prof. Lee Soo Chin, a group of researchers conducted a genome-wide association study meta-analysis of 100,204 colorectal cancer (CRC) cases and 154,587 controls of European and east Asian ancestry. They identified 205 independent risk associations, 50 of which were previously unreported; as well as 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously demonstrated role in CRC. Their findings provide insights into colorectal oncogenesis and establish potential targets across tissues for new CRC treatment and chemoprevention strategies.

Read more at: https://go.nature.com/3GUWt1S