Jiayi Weng 1, Xiaoqiang Xiang 2, Lingwen Ding 3, Andrea Li-Ann Wong 4, Qi Zeng 5, Gautam Sethi 6, Lingzhi Wang 7, Soo Chin Lee 8, Boon Cher Goh 9 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Department of Medicine, Yong …
Daryl Jin Tai Tay 1, Yangyang Song 1, Boya Peng 2, Tan Boon Toh 3, Lissa Hooi 1, Desiree-Faye Kaixin Toh 4, HuiQi Hong 5, Sze Jing Tang 1, Jian Han 1, Wei Liang Gan 1, Tim Hon Man Chan 1, Manchugondanahalli S Krishna 4, Kiran M Patil 4, Manikantha Maraswami 4, Teck Peng Loh 4, Yock Young Dan 6, Lei Zhou 7, Glenn …
Liang Xu 1 2, Ye Chen 1, Yulun Huang 3 4 5, Edwin Sandanaraj 6 7, John S Yu 8, Ruby Yu-Tong Lin 9, Pushkar Dakle 9, Xin-Yu Ke 9, Yuk Kien Chong 6, Lynnette Koh 6 10, Anand Mayakonda 9, Kassoum Nacro 11, Jeffrey Hill 12, Mo-Li Huang 9 13, Sigal Gery 14, See Wee Lim 6, Zhengyun Huang 15, Ying Xu 15, Jianxiang Chen 16 17 18, Longchuan Bai 19 20, Shaomeng Wang 19 20 21 22, Hiroaki Wakimoto 23, Tseng Tsai Yeo 24, Beng Ti …
Topography of Transcriptionally Active Chromatin in Glioblastoma (Sci Adv, Apr 2021) Read More »
Inherited faults (‘mutations’) in the breast cancer gene, BRCA2, can lead to cancers of the breast, ovary or other organs. BRCA2 codes for a protein containing 3,418 building blocks (called …
Reversing Cancer-Causing Faults in the Breast Cancer Gene BRCA2. Read More »
Ayako Nakamura-Ishizu 1, Desmond Chin 2, Takayoshi Matsumura 2, Darren Qiancheng Tan 2, Makiko Kashio Mochizuki 1, Deng Jianwen 2, Toshio Suda 3 1Tokyo women’s medical univeristy, Tokyo, Japan. 2National University of Singapore, Singapore, Singapore. 3Kumamoto Univerisity IRCMS, Japan. Abstract Hematopoietic stem cells …
Michal M Hoppe 1, Patrick Jaynes 1, Joanna D Wardyn 1, Sai Srinivas Upadhyayula 1, Tuan Zea Tan 1, Stefanus Lie 1, Diana G Z Lim 2, Brendan N K Pang 1 2, Sherlly Lim 1, Joe P S Yeong 1, Anthony Karnezis 3, Derek S Chiu 3, Samuel Leung 3, David G Huntsman 3, Anna S Sedukhina 4, Ko Sato 4, Monique …
Maroni G, Bassal MA, Krishnan I, Fhu CW, Savova V, Zilionis R, Maymi VA, Pandell N, Csizmadia E, Zhang J, Storti B, Castaño J, Panella R, Li J, Gustafson CE, …
The pathways that control the behaviour of cells are complex, non-linear and highly redundant. As such, identifying the right molecular target for the development of next-generation drugs is oftentimes akin …
ATP-hydrolyzing enzymes like protein kinases are major drug targets for oncology. Drugs that inhibit these enzymes typically engage their ATP-binding (active) sites to inhibit catalysis. However, these active sites are …
Credit: National University Cancer Institute, Singapore (NCIS) CSI Principal Investigator, Dr. Anand Jeyasekharan, wasrecently involved in a pioneering study performed by the Icahn School of Medicine at Mount Sinai in …
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