Liang Xu 1 2, Ye Chen 1, Yulun Huang 3 4 5, Edwin Sandanaraj 6 7, John S Yu 8, Ruby Yu-Tong Lin 9, Pushkar Dakle 9, Xin-Yu Ke 9, Yuk Kien Chong 6, Lynnette Koh 6 10, Anand Mayakonda 9, Kassoum Nacro 11, Jeffrey Hill 12, Mo-Li Huang 9 13, Sigal Gery 14, See Wee Lim 6, Zhengyun Huang 15, Ying Xu 15, Jianxiang Chen 16 17 18, Longchuan Bai 19 20, Shaomeng Wang 19 20 21 22, Hiroaki Wakimoto 23, Tseng Tsai Yeo 24, Beng Ti …

Topography of Transcriptionally Active Chromatin in Glioblastoma (Sci Adv, Apr 2021) Read More »

Inherited faults (‘mutations’) in the breast cancer gene, BRCA2, can lead to cancers of the breast, ovary or other organs. BRCA2 codes for a protein containing 3,418 building blocks (called …

Reversing Cancer-Causing Faults in the Breast Cancer Gene BRCA2. Read More »

Ayako Nakamura-Ishizu 1, Desmond Chin 2, Takayoshi Matsumura 2, Darren Qiancheng Tan 2, Makiko Kashio Mochizuki 1, Deng Jianwen 2, Toshio Suda 3 1Tokyo women’s medical univeristy, Tokyo, Japan. 2National University of Singapore, Singapore, Singapore. 3Kumamoto Univerisity IRCMS, Japan. Abstract Hematopoietic stem cells …

Prolonged Maintenance of Hematopoietic Stem Cells that Escape From Thrombopoietin Deprivation. (Blood, Mar 2021) Read More »

Michal M Hoppe 1, Patrick Jaynes 1, Joanna D Wardyn 1, Sai Srinivas Upadhyayula 1, Tuan Zea Tan 1, Stefanus Lie 1, Diana G Z Lim 2, Brendan N K Pang 1 2, Sherlly Lim 1, Joe P S Yeong 1, Anthony Karnezis 3, Derek S Chiu 3, Samuel Leung 3, David G Huntsman 3, Anna S Sedukhina 4, Ko Sato 4, Monique …

Quantitative Imaging of RAD51 Expression as a Marker of Platinum Resistance in Ovarian Cancer. (EMBO Mol Med, Mar 2021) Read More »

Maroni G, Bassal MA, Krishnan I, Fhu CW, Savova V, Zilionis R, Maymi VA, Pandell N, Csizmadia E, Zhang J, Storti B, Castaño J, Panella R, Li J, Gustafson CE, …

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. (Commun Biol, Apr 2021) Read More »

The pathways that control the behaviour of cells are complex, non-linear and highly redundant. As such, identifying the right molecular target for the development of next-generation drugs is oftentimes akin …

USD 45M Series B Funding for UK-Based Biopharmaceutical Company’s Drug Discovery Programmes Read More »

ATP-hydrolyzing enzymes like protein kinases are major drug targets for oncology. Drugs that inhibit these enzymes typically engage their ATP-binding (active) sites to inhibit catalysis. However, these active sites are …

Novel First-in-Class Drug Discovery Approach is Breaking New Ground in Anti-Cancer Therapeutics Read More »

Credit: National University Cancer Institute, Singapore (NCIS) CSI Principal Investigator, Dr. Anand Jeyasekharan, wasrecently involved in a pioneering study performed by the Icahn School of Medicine at Mount Sinai in …

Cancer drug may be able to treat inflammation caused by COVID-19 virus, Singapore-US study shows Read More »

Hematopoietic stem cells (HSC) residing in the bone marrow are essential for life-long hematopoiesis. To ensure long term regenerative potential in HSCs, the preservation of HSCs in its quiescent state …

Researchers Unravel Novel Insights on Hematopoietic Stem Cell (HSC) Maintenance and its Mechanism Under Thrombopoietin (Thpo) Deficiency Read More »