Transcriptional reactivation of hTERT is the limiting step in tumorigenesis. While mutations in hTERT promoter present in 19% of cancers are recognized as key drivers of hTERT reactivation, mechanisms by which wildtype hTERT (WT-hTERT) promoter is reactivated, in majority of human cancers, remain unknown.

Most mammalian genes generate messenger RNAs (mRNAs) that consist of central protein-coding regions flanked by variable untranslated regions (UTRs). These UTRs, while not directly involved in protein production, nevertheless harbour

Despite approvals of several therapeutics to treat advanced HCC in the past few years, the impact of anti-angiogenic treatment on HCC patient overall survival remains limited. This suggests there may be alternative, perfusion-independent roles of endothelial cells that support tumor progression.

Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) in multiple cancers. Here, we discovered that besides its well-established role in DNA repair, MSH2 exerts a novel epigenomic function in gastric cancer (GC).

Although hypomethylating agents are currently used to treat patients with cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated.

For decades, scientists and doctors have been searching for the mechanisms underlying the formation of cancers.  Accumulating studies have revealed that each cancer type (e.g. gastric cancer, lung cancer, leukemia,

Joline S J Lim 1, Andrea L A Wong 2, Samuel G W Ow 1, Natalie Y L Ngoi 3, Gloria H J Chan 4, Yvonne L E Ang 5, Wan Qin Chong 6, Siew Eng Lim 4, Yi Wan Lim 6, Matilda Lee 4, Joan R E Choo 7, Hon Lyn

Wei Wen Teo # 1, Xinang Cao # 1 2, Chan-Shuo Wu 1, Hong Kee Tan 1 3, Qiling Zhou 1, Chong Gao 4, Kim Vanuytsel 5 6, Sara S Kumar 5 6, George J Murphy 5 6, Henry Yang 1, Li Chai 7, Daniel G Tenen 8 9 10 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

Linear RNA transcripts are the most common type of RNA molecules found in human cells. A subgroup of functional RNA molecules in a circular structure, called circular RNAs (circRNAs), have

Upadhyayula S Srinivas # 1, Norbert S C Tay # 1, Patrick Jaynes # 1, Akshaya Anbuselvan 1, Gokula K Ramachandran 1, Joanna D Wardyn 1, Michal M Hoppe 1, Phuong Mai Hoang 1, Yanfen Peng 1, Sherlly Lim 1, May Yin Lee 2, Praveen C Peethala 1, Omer An 1, Akshay Shendre 1, Bryce W Q Tan 1, Sherlyn Jemimah 1, Manikandan Lakshmanan 3, Longyu Hu 4, Rekha