Research

Non-Coding RNA LEVER Sequestration of PRC2 Can Mediate Long Range Gene Regulation (Commun Biol, Apr 22)

Wei Wen Teo # 1, Xinang Cao # 1 2, Chan-Shuo Wu 1, Hong Kee Tan 1 3, Qiling Zhou 1, Chong Gao 4, Kim Vanuytsel 5 6, Sara S Kumar 5 6, George J Murphy 5 6, Henry Yang 1, Li Chai 7, Daniel G Tenen 8 9 10 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. […]

Non-Coding RNA LEVER Sequestration of PRC2 Can Mediate Long Range Gene Regulation (Commun Biol, Apr 22) Read More »

PLK1 Inhibition Selectively Induces Apoptosis in ARID1A Deficient Cells Through Uncoupling of Oxygen Consumption from ATP Production. (Oncogene, Mar 22)

Upadhyayula S Srinivas # 1, Norbert S C Tay # 1, Patrick Jaynes # 1, Akshaya Anbuselvan 1, Gokula K Ramachandran 1, Joanna D Wardyn 1, Michal M Hoppe 1, Phuong Mai Hoang 1, Yanfen Peng 1, Sherlly Lim 1, May Yin Lee 2, Praveen C Peethala 1, Omer An 1, Akshay Shendre 1, Bryce W Q Tan 1, Sherlyn Jemimah 1, Manikandan Lakshmanan 3, Longyu Hu 4, Rekha

PLK1 Inhibition Selectively Induces Apoptosis in ARID1A Deficient Cells Through Uncoupling of Oxygen Consumption from ATP Production. (Oncogene, Mar 22) Read More »

Clinical Translation of Patient-Derived Tumour Organoids- Bottlenecks and Strategies. (Biomark Res, Mar 22)

Malia Alexandra Foo # 1, Mingliang You # 2 3, Shing Leng Chan 1 4, Gautam Sethi 5 6, Glenn K Bonney 4 5, Wei-Peng Yong 1 7, Edward Kai-Hua Chow 1 5 6, Eliza Li Shan Fong 1 8, Lingzhi Wang 9 10 11, Boon-Cher Goh 12 13 14 15 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Hangzhou

Clinical Translation of Patient-Derived Tumour Organoids- Bottlenecks and Strategies. (Biomark Res, Mar 22) Read More »

ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022)

Haoqing Shen 1 2, Omer An 1, Xi Ren 1, Yangyang Song 1, Sze Jing Tang 1, Xin-Yu Ke 1 2, Jian Han 1, Daryl Jin Tai Tay 1, Vanessa Hui En Ng 1, Fernando Bellido Molias 1, Priyankaa Pitcheshwar 1 2, Ka Wai Leong 1, Ker-Kan Tan 3 4 5, Henry Yang 1, Leilei Chen 6 7 8 Affiliations 1Cancer Science Institute of Singapore, National

ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022) Read More »

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites. (Genome Res, Feb 2022)

Yi Xiang See 1, Kaijing Chen 1, Melissa J Fullwood 2 Affiliations 1Nanyang Technological University, Cancer Science Institute of Singapore, National University of Singapore. 2Nanyang Technological University, Cancer Science Institute of Singapore, National University of

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites. (Genome Res, Feb 2022) Read More »

Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis. (Cell Mol Life Sci, Feb 2022)

Ng Desi # 1 2, Qing Yun Tong # 1, Velda Teh # 1, Jia Jia Chan # 1, Bin Zhang # 1, Hossein Tabatabaeian 1, Hui Qing Tan 3, Katannya Kapeli 3, Wenhao Jin 3, Chun You Lim 1, Zhi Hao Kwok 1 4, Hwee Tong Tan 2, Shi Wang 5, Bei-En Siew 6, Kuok-Chung Lee 7, Choon-Seng Chong 6 7, Ker-Kan Tan 6 7, Henry Yang 1 2, Dennis Kappei 1 2, Gene W Yeo 3 8, Maxey Ching Ming

Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis. (Cell Mol Life Sci, Feb 2022) Read More »

MiR-138 is a Potent Regulator of the Heterogenous MYC Transcript Population in Cancers. (Oncogene, Dec 2021)

Ng Desi 1 2, Velda Teh 1, Qing Yun Tong 1, Chun You Lim 1, Hossein Tabatabaeian 1, Xiao Hong Chew 1, Avencia Sanchez-Mejias 1 3, Jia Jia Chan 1, Bin Zhang 1, Priyankaa Pitcheshwar 1, Bei-En Siew 4, Shi Wang 5, Kuok-Chung Lee 6, Choon-Seng Chong 4 6, Wai-Kit Cheong 6, Bettina Lieske 4 6, Ian Jse-Wei Tan 6, Ker-Kan Tan 4 6, Yvonne Tay 7 8 Affiliations 1Cancer Science Institute of

MiR-138 is a Potent Regulator of the Heterogenous MYC Transcript Population in Cancers. (Oncogene, Dec 2021) Read More »