Research

ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022)

Haoqing Shen 1 2, Omer An 1, Xi Ren 1, Yangyang Song 1, Sze Jing Tang 1, Xin-Yu Ke 1 2, Jian Han 1, Daryl Jin Tai Tay 1, Vanessa Hui En Ng 1, Fernando Bellido Molias 1, Priyankaa Pitcheshwar 1 2, Ka Wai Leong 1, Ker-Kan Tan 3 4 5, Henry Yang 1, Leilei Chen 6 7 8 Affiliations 1Cancer Science Institute of Singapore, National …

ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022) Read More »

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites. (Genome Res, Feb 2022)

Yi Xiang See 1, Kaijing Chen 1, Melissa J Fullwood 2 Affiliations 1Nanyang Technological University, Cancer Science Institute of Singapore, National University of Singapore. 2Nanyang Technological University, Cancer Science Institute of Singapore, National University of …

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites. (Genome Res, Feb 2022) Read More »

Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis. (Cell Mol Life Sci, Feb 2022)

Ng Desi # 1 2, Qing Yun Tong # 1, Velda Teh # 1, Jia Jia Chan # 1, Bin Zhang # 1, Hossein Tabatabaeian 1, Hui Qing Tan 3, Katannya Kapeli 3, Wenhao Jin 3, Chun You Lim 1, Zhi Hao Kwok 1 4, Hwee Tong Tan 2, Shi Wang 5, Bei-En Siew 6, Kuok-Chung Lee 7, Choon-Seng Chong 6 7, Ker-Kan Tan 6 7, Henry Yang 1 2, Dennis Kappei 1 2, Gene W Yeo 3 8, Maxey Ching Ming …

Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis. (Cell Mol Life Sci, Feb 2022) Read More »

MiR-138 is a Potent Regulator of the Heterogenous MYC Transcript Population in Cancers. (Oncogene, Dec 2021)

Ng Desi 1 2, Velda Teh 1, Qing Yun Tong 1, Chun You Lim 1, Hossein Tabatabaeian 1, Xiao Hong Chew 1, Avencia Sanchez-Mejias 1 3, Jia Jia Chan 1, Bin Zhang 1, Priyankaa Pitcheshwar 1, Bei-En Siew 4, Shi Wang 5, Kuok-Chung Lee 6, Choon-Seng Chong 4 6, Wai-Kit Cheong 6, Bettina Lieske 4 6, Ian Jse-Wei Tan 6, Ker-Kan Tan 4 6, Yvonne Tay 7 8 Affiliations 1Cancer Science Institute of …

MiR-138 is a Potent Regulator of the Heterogenous MYC Transcript Population in Cancers. (Oncogene, Dec 2021) Read More »

ChIP-AP: An Integrated Analysis Pipeline for Unbiased ChIP-seq Analysis. (Brief Bioinform, Jan 2022)

Jeremiah Suryatenggara 1, Kol Jia Yong 1 2, Danielle E Tenen 3, Daniel G Tenen 1 4, Mahmoud A Bassal 1 4 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. 2Department of Biochemistry, Yong Loo Lin School …

ChIP-AP: An Integrated Analysis Pipeline for Unbiased ChIP-seq Analysis. (Brief Bioinform, Jan 2022) Read More »

A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach. (Cell Mol Gastroenterol Hepatol, Jan 2022)

Daisuke Douchi 1, Akihiro Yamamura 1, Junichi Matsuo 2, Jung-Won Lee 3, Napat Nuttonmanit 2, Yi Hui Melissa Lim 2, Kazuto Suda 4, Mitsuhiro Shimura 1, Sabirah Chen 2, ShuChin Pang 2, Kazuyoshi Kohu 2, Mari Kaneko 5, Hiroshi Kiyonari 5, Atsushi Kaneda 6, Hideyuki Yoshida 7, Ichiro Taniuchi 8, Motomi Osato 2, Henry Yang 2, Michiaki Unno 9, Jimmy Bok-Yan So 10, Khay Guan Yeoh 11, Linda Shyue Huey Chuang 12, Suk-Chul Bae 3, Yoshiaki …

A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach. (Cell Mol Gastroenterol Hepatol, Jan 2022) Read More »

Immunohistochemistry Study of Tumor Vascular Normalization and Anti-Angiogenic Effects of Sunitinib Versus Bevacizumab Prior to Dose-Dense Doxorubicin/Cyclophosphamide Chemotherapy in HER2-Negative Breast Cancer. (Breast Cancer Res Treat, Dec 2021)

Kritika Yadav 1 2, Joline Lim 3, Joan Choo 3, Samuel Guan Wei Ow 3, Andrea Wong 3, Matilda Lee 3, Ching Wan Chan 4, Mikael Hartman 4, Siew Eng Lim 3, Natalie Ngoi 3, Siau Wei Tang 4, Yvonne Ang 3, Gloria Chan 3, Wan Qin Chong 3, Hon Lyn Tan 3, Sing Huang Tan 3, Boon Cher Goh 2 3, Soo Chin Lee 5 6 Affiliations …

Immunohistochemistry Study of Tumor Vascular Normalization and Anti-Angiogenic Effects of Sunitinib Versus Bevacizumab Prior to Dose-Dense Doxorubicin/Cyclophosphamide Chemotherapy in HER2-Negative Breast Cancer. (Breast Cancer Res Treat, Dec 2021) Read More »

Super enhancer-mediated upregulation of HJURP promotes growth and survival of t(4;14)-positive multiple myeloma (Cancer Res, Dec 2021)

Yunlu Jia 1, Jianbiao Zhou 2, Tze King Tan 3, Tae-Hoon Chung 2, Yong Xia Chen 4, Jing-Yuan Chooi 2, Takaomi Sanda 3, Melissa Jane Fullwood 5, Sinan Xiong 2, Sabrina Hui Min Toh 6, Kalpnaa Balan 2, Regina WanJu Wong 7, Julia S L Lim 8, Enfan Zhang 9, Zhen Cai 9, Peng Shen 10, Wee Joo Chng 11 Affiliations 1Medical oncology, …

Super enhancer-mediated upregulation of HJURP promotes growth and survival of t(4;14)-positive multiple myeloma (Cancer Res, Dec 2021) Read More »