Research

Single-cell Profiling of Gastric Cardia Adenocarcinoma Reveals Drivers of Cancer Stemness and Therapeutic Targets (Gut, Jun 2023)

Tan P, Chu Y. Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore gmstanp@duke-nus.edu.sg. 2Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore. 3Genome Institute of Singapore, …

Single-cell Profiling of Gastric Cardia Adenocarcinoma Reveals Drivers of Cancer Stemness and Therapeutic Targets (Gut, Jun 2023) Read More »

Comprehensive Molecular Phenotyping Of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities (Gut, Mar 2023)

Xu C, Huang KK, Law JH, Chua JS, Sheng T, Flores NM, Pizzi MP, Okabe A, Tan ALK, Zhu F, Kumar V, Lu X, Benitez AM, Lian BSX, Ma H, …

Comprehensive Molecular Phenotyping Of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities (Gut, Mar 2023) Read More »

[Meta-Analysis] A Pooled Analysis of Outcomes According to Cytogenetic Abnormalities in Patients Receiving Ixazomib- vs Placebo-based Therapy for Multiple Myeloma (Blood Cancer J., Jan 23)

Wee-Joo Chng 1 2, Sagar Lonial 3, Gareth J Morgan 4, Shinsuke Iida 5, Philippe Moreau 6, Shaji K Kumar 7, Philip Twumasi-Ankrah 8, Miguel Villarreal 8, Ajeeta B Dash 8, Alexander Vorog 8, Xiaoquan Zhang 8, Kaveri Suryanarayan 8, Richard Labotka 8, Meletios A Dimopoulos 9, S Vincent Rajkumar 7 Affiliations 1Department of Hematology-Oncology, National University Cancer Institute, Singapore, …

[Meta-Analysis] A Pooled Analysis of Outcomes According to Cytogenetic Abnormalities in Patients Receiving Ixazomib- vs Placebo-based Therapy for Multiple Myeloma (Blood Cancer J., Jan 23) Read More »

[Meta-Analysis] FAM3C in Circulating Tumor-derived Extracellular Vesicles Promotes Non-small Cell Lung Cancer Growth in Secondary Sites (Theranostics, Jan 23)

Win Lwin Thuya 1, Li Ren Kong 1 2 3, Nicholas L Syn 1 4, Ling-Wen Ding 1 5, Esther Sok Hwee Cheow 1, Regina Tong Xin Wong 1, Tingting Wang 1, Robby Miguel Wen-Jing Goh 1, Hongyan Song 1, Migara K Jayasinghe 2, Minh Tn Le 2 3, Jian Cheng Hu 3, Wei-Peng Yong 1 3 6, Soo-Chin Lee 1 3 6, Andrea Li-Ann Wong 1 3 6, Gautam Sethi 2 3, Huynh …

[Meta-Analysis] FAM3C in Circulating Tumor-derived Extracellular Vesicles Promotes Non-small Cell Lung Cancer Growth in Secondary Sites (Theranostics, Jan 23) Read More »

De Novo Protein Fold Design Through Sequence-independent Fragment Assembly Simulations (Proc. Natl. Acad. Sci. U S A, Jan 23)

Robin Pearce 1, Xiaoqiang Huang 1, Gilbert S Omenn 1 2 3 4, Yang Zhang 1 5 6 7 Affiliations 1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109. 2Department of Internal Medicine, University of Michigan, Ann Arbor, MI …

De Novo Protein Fold Design Through Sequence-independent Fragment Assembly Simulations (Proc. Natl. Acad. Sci. U S A, Jan 23) Read More »

A Myb Enhancer-guided Analysis of Basophil and Mast Cell Differentiation (Nat Commun, Nov 22)

Takayoshi Matsumura 1 2 3, Haruhito Totani 4, Yoshitaka Gunji 5, Masahiro Fukuda 6 7, Rui Yokomori 4, Jianwen Deng 4, Malini Rethnam 4, Chong Yang 4, Tze King Tan 4, Tadayoshi Karasawa 5, Kazuomi Kario 8, Masafumi Takahashi 5, Motomi Osato 4, Takaomi Sanda 4 9, Toshio Suda 10 11 12 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. csitkm@nus.edu.sg. …

A Myb Enhancer-guided Analysis of Basophil and Mast Cell Differentiation (Nat Commun, Nov 22) Read More »

Analysis of Clinically Relevant Variants from Ancestrally Diverse Asian Genomes (Nat Commun, Nov 22)

Sock Hoai Chan # 1 2 3, Yasmin Bylstra # 4, Jing Xian Teo 4, Jyn Ling Kuan 4, Nicolas Bertin 5, Mar Gonzalez-Porta 5, Maxime Hebrard 5, Roberto Tirado-Magallanes 5, Joanna Hui Juan Tan 5, Justin Jeyakani 5, Zhihui Li 5, Jin Fang Chai 6, Yap Seng Chong 7 8, Sonia Davila 4 9 10, Liuh Ling Goh 11, Eng Sing Lee 3 12, Eleanor Wong 13, Tien Yin Wong 14; SG10K_Health Consortium; Shyam …

Analysis of Clinically Relevant Variants from Ancestrally Diverse Asian Genomes (Nat Commun, Nov 22) Read More »

Nuclear pCHK1 as a Potential Biomarker of Increased Sensitivity to ATR Inhibition (J Pathol, Nov 22)

Vignesh Sundararajan 1, Tuan Zea Tan 1 2, Diana Lim 3, Yanfen Peng 1, Antje Margret Wengner 4, Natalie Yan Li Ngoi 5, Anand D Jeyasekharan 1, David Shao Peng Tan 1 5 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Genomics and …

Nuclear pCHK1 as a Potential Biomarker of Increased Sensitivity to ATR Inhibition (J Pathol, Nov 22) Read More »