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Stromal reprogramming through dual PDGFR?/? blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors [Cancer Res, Dec 2022]

In collaboration with CSI Singapore’s Prof. Patrick Tan, a group of researchers investigated the mechanisms by which the stroma manipulates the immune microenvironment and facilitates cancer progression and immune evasion. […]

Stromal reprogramming through dual PDGFR?/? blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors [Cancer Res, Dec 2022] Read More »

Deciphering Colorectal Cancer Genetics through Multi-omic Analysis of 100,204 Cases and 154,587 Controls of European and East Asian Ancestries [Nat Genet, Dec 2022]

In collaboration with CSI Singapore’s Prof. Lee Soo Chin, a group of researchers conducted a genome-wide association study meta-analysis of 100,204 colorectal cancer (CRC) cases and 154,587 controls of European

Deciphering Colorectal Cancer Genetics through Multi-omic Analysis of 100,204 Cases and 154,587 Controls of European and East Asian Ancestries [Nat Genet, Dec 2022] Read More »

Real-world outcomes from use of CDK4/6 inhibitors in the management of advanced/metastatic breast cancer in Asia [Ther Adv Med Oncol, Dec 2022]

A group of researchers, led by CSI Singapore’s Prof. Lee Soo Chin, evaluated the clinical outcomes for combinations of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) with anti-oestrogen therapy for treatment of

Real-world outcomes from use of CDK4/6 inhibitors in the management of advanced/metastatic breast cancer in Asia [Ther Adv Med Oncol, Dec 2022] Read More »

A Myb Enhancer-guided Analysis of Basophil and Mast Cell Differentiation (Nat Commun, Nov 22)

Takayoshi Matsumura 1 2 3, Haruhito Totani 4, Yoshitaka Gunji 5, Masahiro Fukuda 6 7, Rui Yokomori 4, Jianwen Deng 4, Malini Rethnam 4, Chong Yang 4, Tze King Tan 4, Tadayoshi Karasawa 5, Kazuomi Kario 8, Masafumi Takahashi 5, Motomi Osato 4, Takaomi Sanda 4 9, Toshio Suda 10 11 12 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. csitkm@nus.edu.sg.

A Myb Enhancer-guided Analysis of Basophil and Mast Cell Differentiation (Nat Commun, Nov 22) Read More »

Analysis of Clinically Relevant Variants from Ancestrally Diverse Asian Genomes (Nat Commun, Nov 22)

Sock Hoai Chan # 1 2 3, Yasmin Bylstra # 4, Jing Xian Teo 4, Jyn Ling Kuan 4, Nicolas Bertin 5, Mar Gonzalez-Porta 5, Maxime Hebrard 5, Roberto Tirado-Magallanes 5, Joanna Hui Juan Tan 5, Justin Jeyakani 5, Zhihui Li 5, Jin Fang Chai 6, Yap Seng Chong 7 8, Sonia Davila 4 9 10, Liuh Ling Goh 11, Eng Sing Lee 3 12, Eleanor Wong 13, Tien Yin Wong 14; SG10K_Health Consortium; Shyam

Analysis of Clinically Relevant Variants from Ancestrally Diverse Asian Genomes (Nat Commun, Nov 22) Read More »

Nuclear pCHK1 as a Potential Biomarker of Increased Sensitivity to ATR Inhibition (J Pathol, Nov 22)

Vignesh Sundararajan 1, Tuan Zea Tan 1 2, Diana Lim 3, Yanfen Peng 1, Antje Margret Wengner 4, Natalie Yan Li Ngoi 5, Anand D Jeyasekharan 1, David Shao Peng Tan 1 5 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Genomics and

Nuclear pCHK1 as a Potential Biomarker of Increased Sensitivity to ATR Inhibition (J Pathol, Nov 22) Read More »

Requirement for TP73 and Genetic Alterations Originating from its Intragenic Super-enhancer in Adult T-cell Leukemia (Leukemia, Sep 2022)

Jolynn Zu Lin Ong # 1, Rui Yokomori # 1, Regina Wan Ju Wong 1, Tze King Tan 1, Ryuzo Ueda 2, Takashi Ishida 3, Shinsuke Iida 4, Takaomi Sanda 5 6 Affiliations 1Cancer Science Institute of Singapore, National University of, Singapore, 117599, Singapore. 2Department of Tumor Immunology,

Requirement for TP73 and Genetic Alterations Originating from its Intragenic Super-enhancer in Adult T-cell Leukemia (Leukemia, Sep 2022) Read More »