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[Meta-Analysis] A Pooled Analysis of Outcomes According to Cytogenetic Abnormalities in Patients Receiving Ixazomib- vs Placebo-based Therapy for Multiple Myeloma (Blood Cancer J., Jan 23)

Wee-Joo Chng 1 2, Sagar Lonial 3, Gareth J Morgan 4, Shinsuke Iida 5, Philippe Moreau 6, Shaji K Kumar 7, Philip Twumasi-Ankrah 8, Miguel Villarreal 8, Ajeeta B Dash 8, Alexander Vorog 8, Xiaoquan Zhang 8, Kaveri Suryanarayan 8, Richard Labotka 8, Meletios A Dimopoulos 9, S Vincent Rajkumar 7 Affiliations 1Department of Hematology-Oncology, National University Cancer Institute, Singapore,

[Meta-Analysis] A Pooled Analysis of Outcomes According to Cytogenetic Abnormalities in Patients Receiving Ixazomib- vs Placebo-based Therapy for Multiple Myeloma (Blood Cancer J., Jan 23) Read More »

[Meta-Analysis] FAM3C in Circulating Tumor-derived Extracellular Vesicles Promotes Non-small Cell Lung Cancer Growth in Secondary Sites (Theranostics, Jan 23)

Win Lwin Thuya 1, Li Ren Kong 1 2 3, Nicholas L Syn 1 4, Ling-Wen Ding 1 5, Esther Sok Hwee Cheow 1, Regina Tong Xin Wong 1, Tingting Wang 1, Robby Miguel Wen-Jing Goh 1, Hongyan Song 1, Migara K Jayasinghe 2, Minh Tn Le 2 3, Jian Cheng Hu 3, Wei-Peng Yong 1 3 6, Soo-Chin Lee 1 3 6, Andrea Li-Ann Wong 1 3 6, Gautam Sethi 2 3, Huynh

[Meta-Analysis] FAM3C in Circulating Tumor-derived Extracellular Vesicles Promotes Non-small Cell Lung Cancer Growth in Secondary Sites (Theranostics, Jan 23) Read More »

De Novo Protein Fold Design Through Sequence-independent Fragment Assembly Simulations (Proc. Natl. Acad. Sci. U S A, Jan 23)

Robin Pearce 1, Xiaoqiang Huang 1, Gilbert S Omenn 1 2 3 4, Yang Zhang 1 5 6 7 Affiliations 1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109. 2Department of Internal Medicine, University of Michigan, Ann Arbor, MI

De Novo Protein Fold Design Through Sequence-independent Fragment Assembly Simulations (Proc. Natl. Acad. Sci. U S A, Jan 23) Read More »

Stromal reprogramming through dual PDGFR?/? blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors [Cancer Res, Dec 2022]

In collaboration with CSI Singapore’s Prof. Patrick Tan, a group of researchers investigated the mechanisms by which the stroma manipulates the immune microenvironment and facilitates cancer progression and immune evasion.

Stromal reprogramming through dual PDGFR?/? blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors [Cancer Res, Dec 2022] Read More »

Deciphering Colorectal Cancer Genetics through Multi-omic Analysis of 100,204 Cases and 154,587 Controls of European and East Asian Ancestries [Nat Genet, Dec 2022]

In collaboration with CSI Singapore’s Prof. Lee Soo Chin, a group of researchers conducted a genome-wide association study meta-analysis of 100,204 colorectal cancer (CRC) cases and 154,587 controls of European

Deciphering Colorectal Cancer Genetics through Multi-omic Analysis of 100,204 Cases and 154,587 Controls of European and East Asian Ancestries [Nat Genet, Dec 2022] Read More »

Real-world outcomes from use of CDK4/6 inhibitors in the management of advanced/metastatic breast cancer in Asia [Ther Adv Med Oncol, Dec 2022]

A group of researchers, led by CSI Singapore’s Prof. Lee Soo Chin, evaluated the clinical outcomes for combinations of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) with anti-oestrogen therapy for treatment of

Real-world outcomes from use of CDK4/6 inhibitors in the management of advanced/metastatic breast cancer in Asia [Ther Adv Med Oncol, Dec 2022] Read More »