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PLK1 Inhibition Selectively Induces Apoptosis in ARID1A Deficient Cells Through Uncoupling of Oxygen Consumption from ATP Production. (Oncogene, Mar 22)

Upadhyayula S Srinivas # 1, Norbert S C Tay # 1, Patrick Jaynes # 1, Akshaya Anbuselvan 1, Gokula K Ramachandran 1, Joanna D Wardyn 1, Michal M Hoppe 1, Phuong Mai Hoang 1, Yanfen Peng 1, Sherlly Lim 1, May Yin Lee 2, Praveen C Peethala 1, Omer An 1, Akshay Shendre 1, Bryce W Q Tan 1, Sherlyn Jemimah 1, Manikandan Lakshmanan 3, Longyu Hu 4, Rekha …

PLK1 Inhibition Selectively Induces Apoptosis in ARID1A Deficient Cells Through Uncoupling of Oxygen Consumption from ATP Production. (Oncogene, Mar 22) Read More »

Clinical Translation of Patient-Derived Tumour Organoids- Bottlenecks and Strategies. (Biomark Res, Mar 22)

Malia Alexandra Foo # 1, Mingliang You # 2 3, Shing Leng Chan 1 4, Gautam Sethi 5 6, Glenn K Bonney 4 5, Wei-Peng Yong 1 7, Edward Kai-Hua Chow 1 5 6, Eliza Li Shan Fong 1 8, Lingzhi Wang 9 10 11, Boon-Cher Goh 12 13 14 15 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. 2Hangzhou …

Clinical Translation of Patient-Derived Tumour Organoids- Bottlenecks and Strategies. (Biomark Res, Mar 22) Read More »

ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022)

Haoqing Shen 1 2, Omer An 1, Xi Ren 1, Yangyang Song 1, Sze Jing Tang 1, Xin-Yu Ke 1 2, Jian Han 1, Daryl Jin Tai Tay 1, Vanessa Hui En Ng 1, Fernando Bellido Molias 1, Priyankaa Pitcheshwar 1 2, Ka Wai Leong 1, Ker-Kan Tan 3 4 5, Henry Yang 1, Leilei Chen 6 7 8 Affiliations 1Cancer Science Institute of Singapore, National …

ADARs act as potent regulators of circular transcriptome in cancer (Nat Commun, Mar 2022) Read More »

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites. (Genome Res, Feb 2022)

Yi Xiang See 1, Kaijing Chen 1, Melissa J Fullwood 2 Affiliations 1Nanyang Technological University, Cancer Science Institute of Singapore, National University of Singapore. 2Nanyang Technological University, Cancer Science Institute of Singapore, National University of …

MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites. (Genome Res, Feb 2022) Read More »

Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis. (Cell Mol Life Sci, Feb 2022)

Ng Desi # 1 2, Qing Yun Tong # 1, Velda Teh # 1, Jia Jia Chan # 1, Bin Zhang # 1, Hossein Tabatabaeian 1, Hui Qing Tan 3, Katannya Kapeli 3, Wenhao Jin 3, Chun You Lim 1, Zhi Hao Kwok 1 4, Hwee Tong Tan 2, Shi Wang 5, Bei-En Siew 6, Kuok-Chung Lee 7, Choon-Seng Chong 6 7, Ker-Kan Tan 6 7, Henry Yang 1 2, Dennis Kappei 1 2, Gene W Yeo 3 8, Maxey Ching Ming …

Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis. (Cell Mol Life Sci, Feb 2022) Read More »

p53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain). (Oncogene, Feb 2022)

Phaik Ju Teoh 1 2, Omer An 3, Tae-Hoon Chung 3, Thamil Vaiyapuri 4, Anandhkumar Raju 4, Michal M Hoppe 3, Sabrina H M Toh 3, Wilson Wang 5 6, Ming Chun Chan 5 6, Melissa J Fullwood 3, Anand D Jeyasekharan 7 3 8 9, Vinay Tergaonkar 4, Leilei Chen 3, Henry Yang 3, Wee Joo Chng 7 3 8 9 Affiliations 1Department of Medicine, Yong Loo …

p53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain). (Oncogene, Feb 2022) Read More »

MiR-138 is a Potent Regulator of the Heterogenous MYC Transcript Population in Cancers. (Oncogene, Dec 2021)

Ng Desi 1 2, Velda Teh 1, Qing Yun Tong 1, Chun You Lim 1, Hossein Tabatabaeian 1, Xiao Hong Chew 1, Avencia Sanchez-Mejias 1 3, Jia Jia Chan 1, Bin Zhang 1, Priyankaa Pitcheshwar 1, Bei-En Siew 4, Shi Wang 5, Kuok-Chung Lee 6, Choon-Seng Chong 4 6, Wai-Kit Cheong 6, Bettina Lieske 4 6, Ian Jse-Wei Tan 6, Ker-Kan Tan 4 6, Yvonne Tay 7 8 Affiliations 1Cancer Science Institute of …

MiR-138 is a Potent Regulator of the Heterogenous MYC Transcript Population in Cancers. (Oncogene, Dec 2021) Read More »