Researchers led by Principal Investigator, Assistant Professor Dennis Kappei, have developed a new method that allows scientists to better understand how DNA activity is organised and regulated inside our cells. The study introduces a method called qChIP-MS, which enables researchers to identify groups of proteins that work together at specific locations on DNA.
DNA in our cells is packaged into a structure known as chromatin. Chromatin helps determine which genes are switched on or off, protects the genome from damage, and influences how cells respond to stress. Problems in chromatin regulation have been linked to cancer, ageing and other diseases.
Understanding which proteins gather at specific regions of the genome is important because these protein networks help control gene activity and influence how cells behave in health and disease.
This work was published in Nature Communications on 10 May 2026.