In collaboration with CSI Singapore’s Prof. Patrick Tan, a group of researchers investigated the mechanisms by which the stroma manipulates the immune microenvironment and facilitates cancer progression and immune evasion. They were able to upregulate immunosuppression by stimulating cancer-associated fibroblasts (CAFs) with platelet-derived growth factors (PDGFs) and reverse the immunosuppression by blocking PDGF receptors through stromal modification. Their findings highlight the impact of stromal reprogramming on immune reactivation and the potential for combined immunotherapy for patients with fibrotic cancer.

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