Latest @ CSI.

August 6, 2025

Congratulations on the NMRC OF-YIRG Award, Dr. Jun Liu!

We’re proud to share that CSI Singapore Research Fellow, Dr. Jun Liu has been awarded the NMRC Open Fund – Young Individual Research Grant (OF-YIRG) for his project titled “Genome-Wide...

July 28, 2025

Conclusion of the The Diana Koh Breakthroughs in Cancer Learning Series 2025

The Diana Koh Breakthroughs in Cancer Learning Series 2025 concluded with a powerful session of science, storytelling, and inspiration.Held at the Science Centre Singapore, the second installation of the Diana...

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Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer (Cell Metabolism Nov 2025)

Authors Zhengwei Wu , Zhenxun Wang , Seow Qi Ng , Jessica Alice Lidster , Paul Schwerd-Kleine , Zi Jin Cheryl Phua , Kai Lay Esther Peh , Yin Ying […]

Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone (JCI, July 2025)

Authors: Valeria Cancila, Giorgio Bertolazzi, Allison S.Y. Chan, Giovanni Medico, Giulia Bastianello, Gaia Morello, Daniel Paysan, Clemence Lai, Liang Hong, Girija Shenoy, Patrick W. Jaynes, Giovanna Schiavoni, Fabrizio Mattei, Silvia […]

Prospective Clinical Validation of a Combinatorial Functional Precision Medicine Platform in Relapsed/Refractory Non-Hodgkin’s Lymphoma (JCO Precision Oncology, September 2025)

Treating patients whose non-Hodgkin’s lymphoma (NHL) has come back or stopped responding to therapy remains very difficult. Many eventually run out of standard treatment options. A team led by Dr. […]

🚨 New Milestone in Cancer Research and Precision Medicine 🚨

CSI Singapore and Next&Bio Launch Joint Organoid Research Laboratory at NUS We are excited to announce the launch of a joint organoid research laboratory by Next&Bio and the Cancer Science […]

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability (Molecular Cell 2025)

Michael A. Longo1 ∙ Syed Moiz Ahmed2,10 ∙ Yue Chen3,10 ∙ Chi-Lin Tsai1,10 ∙ Sarita Namjoshi1 ∙ Runze Shen1 ∙ Zamal Ahmed1 ∙ Xiaoyan Wang1 ∙ Rajika L. Perera4 ∙ […]

A Multi-task Domain-adapted Model to Predict Chemotherapy Response from Mutations in Recurrently Altered Cancer Genes (iScience, March 2025)

Aishwarya Jayagopal1, 7 ∙ Robert J. Walsh2,7 ∙ Krishna Kumar Hariprasannan1 ∙ Ragunathan Mariappan1 ∙ Debabrata Mahapatra6 ∙ Patrick William Jaynes3 ∙ Diana Lim4 ∙ David Shao Peng Tan2,3,5 ∙ Tuan Zea Tan3 ∙ Jason J. Pitt3 ∙ Anand D. Jeyasekharan2,3 Vaibhav Rajan1, 8 1. Department of Information Systems and Analytics, School of Computing, National University of Singapore, Singapore 117417, Singapore […]

The ADAR1-Regulated Cytoplasmic dsRNA-Sensing Pathway is A Novel Mechanism of Lenalidomide Resistance in Multiple Myeloma (Blood, March 2025)

Mun Yee Koh 1, Tae-Hoon Chung 1, Nicole Xin Ning Tang 1, Sabrina Hui Min Toh 1, Jianbiao Zhou 1, Tze King Tan 1, Leilei Chen 1,2, Wee Joo Chng […]

Pembrolizumab With or Without Bevacizumab in Platinum-Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Randomized, Open-Label, Phase 2 Trial (The Lancet Oncology, Feb 2025)

Wan-Qin Chong, MBBS a ∙ Jia-Li Low, MBBS a ∙ Joshua K Tay, PhD b,d ∙ Thi Bich Uyen Le, BSca ∙ Grace Shi-Qing Goh, BSc g ∙ Kenneth Sooi, MBBS a ∙ Hui-Lin Teo, MBBS h ∙ Seng-Wee Cheo, MD a ∙ Regina Tong-Xin Wong, BSc g ∙ Jens Samol, MD h,j,k ∙ Ming-Yann Lim, MBBS i ∙ Hao Li, MBBS i ∙ Niranjan Shirgaonkar, MSc l ∙ Shumei Chia, PhD l ∙ Lingzhi Wang, PhD f,g ∙ Anil Gopinathan, MBBS c ∙ Donovan Kum-Chuen Eu, MBBS b ∙ Raymond King-Yin Tsang, MBChB b,d ∙ Prof Kwok-Seng Loh, MBBS b,d ∙ Prof Han-Chong Toh, MBBS m ∙ Nicholas Syn, MBBSe ∙ Li-Ren Kong, PhD f,g ∙ Ramanuj Dasgupta, PhD l ∙ Bee-Choo Tai, PhD n ∙ Yaw-Chyn Lim, PhD […]

Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia (Leukemia, Nov 2024)

Xiaoman Shao # 1, Rui Yokomori # 1, Jolynn Zu Lin Ong 1, Haoqing Shen 1, Dennis Kappei 1 2 3, Leilei Chen 1 3, Allen Eng Juh Yeoh 1 3 4, Shi Hao Tan 1, Takaomi Sanda 5 6 7 8 Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. Department of Biochemistry, […]

ZBTB48 is a Priming Factor Regulating B-Cell-Specific CIITA Expression (The EMBO Journal, Dec 2024, Cover story)

Grishma Rane 1, Vivian L S Kuan 1, Suman Wang 2, Michelle Meng Huang Mok 1, Vartika Khanchandani 1, Julia Hansen 1, Ieva Norvaisaite 1, Naasyidah Zulkaflee 1, Wai Khang Yong 1, Arne Jahn 3 4 5 6, Vineeth T Mukundan 1, Yunyu Shi 2, Motomi Osato 1, Fudong Li 2, Dennis Kappei 7 8 9 Affiliations 1Cancer Science Institute of Singapore, National University […]

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