Latest @ CSI.

March 10, 2025

Professor Ashok Venkitaraman Elected as Fellow of Prestigious AACR Academy

Warmest congratulations to Professor Ashok Venkitaraman, Director of CSI Singapore, who is among 33 distinguished scientists from around the world elected to the 2025 class of Fellows of the American...

February 7, 2025

Congratulations to CSI members – Asst. Prof. Anand Jeyasekharan & Dr. Stephen Chong!

About the Award/Grant: The Clinician Scientist Award (Senior Investigator) Category is for a senior clinician scientist who has demonstrated sustained, high levels of productivity and leadership in this field, and...

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A Multi-task Domain-adapted Model to Predict Chemotherapy Response from Mutations in Recurrently Altered Cancer Genes (iScience, March 2025)

Aishwarya Jayagopal1, 7 ∙ Robert J. Walsh2,7 ∙ Krishna Kumar Hariprasannan1 ∙ Ragunathan Mariappan1 ∙ Debabrata Mahapatra6 ∙ Patrick William Jaynes3 ∙ Diana Lim4 ∙ David Shao Peng Tan2,3,5 ∙ Tuan Zea Tan3 ∙ Jason J. Pitt3 ∙ Anand D. Jeyasekharan2,3 Vaibhav Rajan1, 8 1. Department of Information Systems and Analytics, School of Computing, National University of Singapore, Singapore 117417, Singapore […]

Pembrolizumab With or Without Bevacizumab in Platinum-Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Randomized, Open-Label, Phase 2 Trial (The Lancet Oncology, Feb 2025)

Wan-Qin Chong, MBBS a ∙ Jia-Li Low, MBBS a ∙ Joshua K Tay, PhD b,d ∙ Thi Bich Uyen Le, BSca ∙ Grace Shi-Qing Goh, BSc g ∙ Kenneth Sooi, MBBS a ∙ Hui-Lin Teo, MBBS h ∙ Seng-Wee Cheo, MD a ∙ Regina Tong-Xin Wong, BSc g ∙ Jens Samol, MD h,j,k ∙ Ming-Yann Lim, MBBS i ∙ Hao Li, MBBS i ∙ Niranjan Shirgaonkar, MSc l ∙ Shumei Chia, PhD l ∙ Lingzhi Wang, PhD f,g ∙ Anil Gopinathan, MBBS c ∙ Donovan Kum-Chuen Eu, MBBS b ∙ Raymond King-Yin Tsang, MBChB b,d ∙ Prof Kwok-Seng Loh, MBBS b,d ∙ Prof Han-Chong Toh, MBBS m ∙ Nicholas Syn, MBBSe ∙ Li-Ren Kong, PhD f,g ∙ Ramanuj Dasgupta, PhD l ∙ Bee-Choo Tai, PhD n ∙ Yaw-Chyn Lim, PhD […]

Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia (Leukemia, Nov 2024)

Xiaoman Shao # 1, Rui Yokomori # 1, Jolynn Zu Lin Ong 1, Haoqing Shen 1, Dennis Kappei 1 2 3, Leilei Chen 1 3, Allen Eng Juh Yeoh 1 3 4, Shi Hao Tan 1, Takaomi Sanda 5 6 7 8 Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. Department of Biochemistry, […]

ZBTB48 is a Priming Factor Regulating B-Cell-Specific CIITA Expression (The EMBO Journal, Dec 2024, Cover story)

Grishma Rane 1, Vivian L S Kuan 1, Suman Wang 2, Michelle Meng Huang Mok 1, Vartika Khanchandani 1, Julia Hansen 1, Ieva Norvaisaite 1, Naasyidah Zulkaflee 1, Wai Khang Yong 1, Arne Jahn 3 4 5 6, Vineeth T Mukundan 1, Yunyu Shi 2, Motomi Osato 1, Fudong Li 2, Dennis Kappei 7 8 9 Affiliations 1Cancer Science Institute of Singapore, National University […]

Fratricide-resistant CD7-CAR T cells in T-ALL (Nature Medicine, Sept 2024)

Bernice L Z Oh 1 2, Noriko Shimasaki 2, Elaine Coustan-Smith 2, Esther Chan 3, Limei Poon 3, Shawn H R Lee 1 2, Frances Yeap 1 2, Lip Kun Tan 3, Louis Y A Chai 4, Nina Le Bert 5, Nicole Tan 5, Antonio Bertoletti 5, Siew Peng Chen 2, Francesca Del Bufalo 6, Marco Becilli 6, Franco Locatelli 7 8, Allen E J Yeoh 9 10 11 12, Dario […]

Super Enhancer Acquisition Drives Expression of Oncogenic PPP1R15B that Regulates Protein Homeostasis in Multiple Myeloma (Nature Communications, Aug 2024)

Sinan Xiong 1 2, Jianbiao Zhou 3 4 5, Tze King Tan 2, Tae-Hoon Chung 2, Tuan Zea Tan 2, Sabrina Hui-Min Toh 2, Nicole Xin Ning Tang 2, Yunlu Jia 6, Yi Xiang See 2, Melissa Jane Fullwood 2 7 8 9, Takaomi Sanda 1 2, Wee-Joo Chng 10 11 12 13 Affiliations 1. Department of Medicine, Yong Loo Lin School of […]

Oncogenic Dependency on SWI/SNF Chromatin Remodeling Factors in T-cell Acute Lymphoblastic Leukemia (Leukemia, Jul 2024)

Hyoju Kim 1, Tze King Tan 1, Dean Zi Yang Lee 1, Xiao Zi Huang 1, Jolynn Zu Lin Ong 1, Michelle A Kelliher 2, Allen Eng Juh Yeoh 1 3, Takaomi Sanda 4 5 6, Shi Hao Tan 1 Affiliations 1Cancer Science Institute of Singapore, National University of, Singapore, […]

PARP4 Interacts with hnRNPM to Regulate Splicing during Lung Cancer Progression (Genome Medicine, Jul 2024)

Yi Fei Lee 1 2, Cheryl Zi Jin Phua 1, Ju Yuan 1, Bin Zhang 3 4 5, May Yin Lee 1, Srinivasaraghavan Kannan 6, Yui Hei Jasper Chiu 1, Casslynn Wei Qian Koh 1, Choon Kong Yap 1, Edwin Kok Hao Lim 1, Jianbin Chen 1, Yuhua Lim 1, Jane Jia Hui Lee 1, Anders Jacobsen Skanderup 1, Zhenxun Wang 1 7, Weiwei […]

Hepatocyte-macrophage Crosstalk via the PGRN-EGFR Axis Modulates ADAR1-mediated Immunity in the Liver (Cell Reports, Jun 2024)

Wei Liang Gan 1, Xi Ren 1, Vanessa Hui En Ng 1, Larry Ng 1, Yangyang Song 1, Vincent Tano 1, Jian Han 1, Omer An 1, Jinghe Xie 2, Bryan Y L Ng 1, Daryl Jin Tai Tay 1, Sze Jing Tang 1, Haoqing Shen 1, Shruti Khare 3, Kelvin Han Chung Chong 4, Dan Yock Young 5, Bin Wu 4, Ramanuj DasGupta 3, Leilei […]

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