Latest @ CSI.

May 5, 2022

CSI Principal Investigator and Senior Research Scientist Receive Awards at the Asian Fund for Cancer Research’s (AFCR) 2021 BRACE Award Venture Competition

Congratulations to A/Prof. Edward Kai-Hua Chow and Dr. Bee Hui Liu, who have recently won awards at the Asian Fund for Cancer Research’s (AFCR) 2021 BRACE Award Venture Competition, a...

May 5, 2022

Multilayered Control of Splicing Regulatory Networks by DAP3 Leads to Widespread Alternative Splicing Changes in Cancer. (Nat Commun, Apr 22)

Jian Han 1, Omer An 2, Xi Ren 2, Yangyang Song 2, Sze Jing Tang 2, Haoqing Shen 2, Xinyu Ke 2, Vanessa Hui En Ng 2, Daryl Jin Tai Tay 2, Hui Qing Tan 3, Dennis Kappei 2 4 5, Henry Yang 2, Leilei Chen 6 7 8 Affiliations 1Cancer Science Institute of Singapore, National University of Singapore,...

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Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia (Leukemia, Nov 2024)

Xiaoman Shao # 1, Rui Yokomori # 1, Jolynn Zu Lin Ong 1, Haoqing Shen 1, Dennis Kappei 1 2 3, Leilei Chen 1 3, Allen Eng Juh Yeoh 1 3 4, Shi Hao Tan 1, Takaomi Sanda 5 6 7 8 Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. Department of Biochemistry, …

Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia (Leukemia, Nov 2024) Read More »

ZBTB48 is a Priming Factor Regulating B-Cell-Specific CIITA Expression (The EMBO Journal, Dec 2024, Cover story)

Grishma Rane 1, Vivian L S Kuan 1, Suman Wang 2, Michelle Meng Huang Mok 1, Vartika Khanchandani 1, Julia Hansen 1, Ieva Norvaisaite 1, Naasyidah Zulkaflee 1, Wai Khang Yong 1, Arne Jahn 3 4 5 6, Vineeth T Mukundan 1, Yunyu Shi 2, Motomi Osato 1, Fudong Li 2, Dennis Kappei 7 8 9 Affiliations 1Cancer Science Institute of Singapore, National University …

ZBTB48 is a Priming Factor Regulating B-Cell-Specific CIITA Expression (The EMBO Journal, Dec 2024, Cover story) Read More »

Fratricide-resistant CD7-CAR T cells in T-ALL (Nature Medicine, Sept 2024)

Bernice L Z Oh 1 2, Noriko Shimasaki 2, Elaine Coustan-Smith 2, Esther Chan 3, Limei Poon 3, Shawn H R Lee 1 2, Frances Yeap 1 2, Lip Kun Tan 3, Louis Y A Chai 4, Nina Le Bert 5, Nicole Tan 5, Antonio Bertoletti 5, Siew Peng Chen 2, Francesca Del Bufalo 6, Marco Becilli 6, Franco Locatelli 7 8, Allen E J Yeoh 9 10 11 12, Dario …

Fratricide-resistant CD7-CAR T cells in T-ALL (Nature Medicine, Sept 2024) Read More »

Super Enhancer Acquisition Drives Expression of Oncogenic PPP1R15B that Regulates Protein Homeostasis in Multiple Myeloma (Nature Communications, Aug 2024)

Sinan Xiong 1 2, Jianbiao Zhou 3 4 5, Tze King Tan 2, Tae-Hoon Chung 2, Tuan Zea Tan 2, Sabrina Hui-Min Toh 2, Nicole Xin Ning Tang 2, Yunlu Jia 6, Yi Xiang See 2, Melissa Jane Fullwood 2 7 8 9, Takaomi Sanda 1 2, Wee-Joo Chng 10 11 12 13 Affiliations 1. Department of Medicine, Yong Loo Lin School of …

Super Enhancer Acquisition Drives Expression of Oncogenic PPP1R15B that Regulates Protein Homeostasis in Multiple Myeloma (Nature Communications, Aug 2024) Read More »

Oncogenic Dependency on SWI/SNF Chromatin Remodeling Factors in T-cell Acute Lymphoblastic Leukemia (Leukemia, Jul 2024)

Hyoju Kim 1, Tze King Tan 1, Dean Zi Yang Lee 1, Xiao Zi Huang 1, Jolynn Zu Lin Ong 1, Michelle A Kelliher 2, Allen Eng Juh Yeoh 1 3, Takaomi Sanda 4 5 6, Shi Hao Tan 1 Affiliations 1Cancer Science Institute of Singapore, National University of, Singapore, …

Oncogenic Dependency on SWI/SNF Chromatin Remodeling Factors in T-cell Acute Lymphoblastic Leukemia (Leukemia, Jul 2024) Read More »

PARP4 Interacts with hnRNPM to Regulate Splicing during Lung Cancer Progression (Genome Medicine, Jul 2024)

Yi Fei Lee 1 2, Cheryl Zi Jin Phua 1, Ju Yuan 1, Bin Zhang 3 4 5, May Yin Lee 1, Srinivasaraghavan Kannan 6, Yui Hei Jasper Chiu 1, Casslynn Wei Qian Koh 1, Choon Kong Yap 1, Edwin Kok Hao Lim 1, Jianbin Chen 1, Yuhua Lim 1, Jane Jia Hui Lee 1, Anders Jacobsen Skanderup 1, Zhenxun Wang 1 7, Weiwei …

PARP4 Interacts with hnRNPM to Regulate Splicing during Lung Cancer Progression (Genome Medicine, Jul 2024) Read More »

Hepatocyte-macrophage Crosstalk via the PGRN-EGFR Axis Modulates ADAR1-mediated Immunity in the Liver (Cell Reports, Jun 2024)

Wei Liang Gan 1, Xi Ren 1, Vanessa Hui En Ng 1, Larry Ng 1, Yangyang Song 1, Vincent Tano 1, Jian Han 1, Omer An 1, Jinghe Xie 2, Bryan Y L Ng 1, Daryl Jin Tai Tay 1, Sze Jing Tang 1, Haoqing Shen 1, Shruti Khare 3, Kelvin Han Chung Chong 4, Dan Yock Young 5, Bin Wu 4, Ramanuj DasGupta 3, Leilei …

Hepatocyte-macrophage Crosstalk via the PGRN-EGFR Axis Modulates ADAR1-mediated Immunity in the Liver (Cell Reports, Jun 2024) Read More »

A PRMT5-ZNF326 Axis Mediates Innate Immune Activation Upon Replication Stress (Science Advances, Jun 2024)

Phuong Mai Hoang 1, Denis Torre 2 3 4, Patrick Jaynes 1, Jessica Ho 5, Kevin Mohammed 2 3 4 6, Erik Alvstad 7 8, Wan Yee Lam 4 6, Vartika Khanchandani 1, Jie Min Lee 1, Chin Min Clarissa Toh 1, Rui Xue Lee 1, Akshaya Anbuselvan 1, Sukchan Lee 9, Robert P Sebra 4, Martin J Walsh 4 6, Ivan Marazzi 7 8, Dennis Kappei 1 10 11, Ernesto Guccione 2 3 4 6, Anand D Jeyasekharan 1 11 12 13 Affiliations …

A PRMT5-ZNF326 Axis Mediates Innate Immune Activation Upon Replication Stress (Science Advances, Jun 2024) Read More »

Spatially-resolved Transcriptomics Reveal Macrophage Heterogeneity and Prognostic Significance in Diffuse Large B-cell Lymphoma (Nature Communications, Mar 2024)

Min Liu 1 2 3, Giorgio Bertolazzi 4 5, Shruti Sridhar 1, Rui Xue Lee 1, Patrick Jaynes 1, Kevin Mulder 6 7 8, Nicholas Syn 9 10, Michal Marek Hoppe 1, Shuangyi Fan 9, Yanfen Peng 1, Jocelyn Thng 1, Reiya Chua 11, Jayalakshmi 11, Yogeshini Batumalai 11, Sanjay De Mel 11 12, Limei Poon 11 12, Esther Hian Li Chan 11 12, Joanne Lee 11 12, Susan Swee-Shan Hue 9 12, Sheng-Tsung Chang 13, Shih-Sung Chuang 13, K George Chandy 14, Xiaofei Ye 15, Qiang …

Spatially-resolved Transcriptomics Reveal Macrophage Heterogeneity and Prognostic Significance in Diffuse Large B-cell Lymphoma (Nature Communications, Mar 2024) Read More »

Deciphering the Regulatory Landscape of Murine Splenic Response to Anemic Stress at Single-cell Resolution (Blood Advances, Feb 2024)

Chong Yang 1, Rui Yokomori 1, Lee Hui Chua 1, Shi Hao Tan 1, Mun Yee Koh 1, Haruhito Totani 1, Takaomi Sanda 1, Toshio Suda 1 2 Affiliations 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 2International …

Deciphering the Regulatory Landscape of Murine Splenic Response to Anemic Stress at Single-cell Resolution (Blood Advances, Feb 2024) Read More »

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