Latest @ CSI.

January 30, 2023

Computational design of novel protein folds

CSI Singapore’s newest staff addition, Professor Yang Zhang, recently led a group of researchers in creating a software, called FoldDesign, which can design protein structures without utilizing known scaffolds from...

January 10, 2023

Stromal reprogramming through dual PDGFR?/? blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors [Cancer Res, Dec 2022]

In collaboration with CSI Singapore’s Prof. Patrick Tan, a group of researchers investigated the mechanisms by which the stroma manipulates the immune microenvironment and facilitates cancer progression and immune evasion....

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Fratricide-resistant CD7-CAR T cells in T-ALL (Nature Medicine, Sept 2024)

Bernice L Z Oh 1 2, Noriko Shimasaki 2, Elaine Coustan-Smith 2, Esther Chan 3, Limei Poon 3, Shawn H R Lee 1 2, Frances Yeap 1 2, Lip Kun Tan 3, Louis Y A Chai 4, Nina Le Bert 5, Nicole Tan 5, Antonio Bertoletti 5, Siew Peng Chen 2, Francesca Del Bufalo 6, Marco Becilli 6, Franco Locatelli 7 8, Allen E J Yeoh 9 10 11 12, Dario …

Fratricide-resistant CD7-CAR T cells in T-ALL (Nature Medicine, Sept 2024) Read More »

Super Enhancer Acquisition Drives Expression of Oncogenic PPP1R15B that Regulates Protein Homeostasis in Multiple Myeloma (Nature Communications, Aug 2024)

Sinan Xiong 1 2, Jianbiao Zhou 3 4 5, Tze King Tan 2, Tae-Hoon Chung 2, Tuan Zea Tan 2, Sabrina Hui-Min Toh 2, Nicole Xin Ning Tang 2, Yunlu Jia 6, Yi Xiang See 2, Melissa Jane Fullwood 2 7 8 9, Takaomi Sanda 1 2, Wee-Joo Chng 10 11 12 13 Affiliations 1. Department of Medicine, Yong Loo Lin School of …

Super Enhancer Acquisition Drives Expression of Oncogenic PPP1R15B that Regulates Protein Homeostasis in Multiple Myeloma (Nature Communications, Aug 2024) Read More »

Oncogenic Dependency on SWI/SNF Chromatin Remodeling Factors in T-cell Acute Lymphoblastic Leukemia (Leukemia, Jul 2024)

Hyoju Kim 1, Tze King Tan 1, Dean Zi Yang Lee 1, Xiao Zi Huang 1, Jolynn Zu Lin Ong 1, Michelle A Kelliher 2, Allen Eng Juh Yeoh 1 3, Takaomi Sanda 4 5 6, Shi Hao Tan 1 Affiliations 1Cancer Science Institute of Singapore, National University of, Singapore, …

Oncogenic Dependency on SWI/SNF Chromatin Remodeling Factors in T-cell Acute Lymphoblastic Leukemia (Leukemia, Jul 2024) Read More »

PARP4 Interacts with hnRNPM to Regulate Splicing during Lung Cancer Progression (Genome Medicine, Jul 2024)

Yi Fei Lee 1 2, Cheryl Zi Jin Phua 1, Ju Yuan 1, Bin Zhang 3 4 5, May Yin Lee 1, Srinivasaraghavan Kannan 6, Yui Hei Jasper Chiu 1, Casslynn Wei Qian Koh 1, Choon Kong Yap 1, Edwin Kok Hao Lim 1, Jianbin Chen 1, Yuhua Lim 1, Jane Jia Hui Lee 1, Anders Jacobsen Skanderup 1, Zhenxun Wang 1 7, Weiwei …

PARP4 Interacts with hnRNPM to Regulate Splicing during Lung Cancer Progression (Genome Medicine, Jul 2024) Read More »

Hepatocyte-macrophage Crosstalk via the PGRN-EGFR Axis Modulates ADAR1-mediated Immunity in the Liver (Cell Reports, Jun 2024)

Wei Liang Gan 1, Xi Ren 1, Vanessa Hui En Ng 1, Larry Ng 1, Yangyang Song 1, Vincent Tano 1, Jian Han 1, Omer An 1, Jinghe Xie 2, Bryan Y L Ng 1, Daryl Jin Tai Tay 1, Sze Jing Tang 1, Haoqing Shen 1, Shruti Khare 3, Kelvin Han Chung Chong 4, Dan Yock Young 5, Bin Wu 4, Ramanuj DasGupta 3, Leilei …

Hepatocyte-macrophage Crosstalk via the PGRN-EGFR Axis Modulates ADAR1-mediated Immunity in the Liver (Cell Reports, Jun 2024) Read More »

A PRMT5-ZNF326 Axis Mediates Innate Immune Activation Upon Replication Stress (Science Advances, Jun 2024)

Phuong Mai Hoang 1, Denis Torre 2 3 4, Patrick Jaynes 1, Jessica Ho 5, Kevin Mohammed 2 3 4 6, Erik Alvstad 7 8, Wan Yee Lam 4 6, Vartika Khanchandani 1, Jie Min Lee 1, Chin Min Clarissa Toh 1, Rui Xue Lee 1, Akshaya Anbuselvan 1, Sukchan Lee 9, Robert P Sebra 4, Martin J Walsh 4 6, Ivan Marazzi 7 8, Dennis Kappei 1 10 11, Ernesto Guccione 2 3 4 6, Anand D Jeyasekharan 1 11 12 13 Affiliations …

A PRMT5-ZNF326 Axis Mediates Innate Immune Activation Upon Replication Stress (Science Advances, Jun 2024) Read More »

Spatially-resolved Transcriptomics Reveal Macrophage Heterogeneity and Prognostic Significance in Diffuse Large B-cell Lymphoma (Nature Communications, Mar 2024)

Min Liu 1 2 3, Giorgio Bertolazzi 4 5, Shruti Sridhar 1, Rui Xue Lee 1, Patrick Jaynes 1, Kevin Mulder 6 7 8, Nicholas Syn 9 10, Michal Marek Hoppe 1, Shuangyi Fan 9, Yanfen Peng 1, Jocelyn Thng 1, Reiya Chua 11, Jayalakshmi 11, Yogeshini Batumalai 11, Sanjay De Mel 11 12, Limei Poon 11 12, Esther Hian Li Chan 11 12, Joanne Lee 11 12, Susan Swee-Shan Hue 9 12, Sheng-Tsung Chang 13, Shih-Sung Chuang 13, K George Chandy 14, Xiaofei Ye 15, Qiang …

Spatially-resolved Transcriptomics Reveal Macrophage Heterogeneity and Prognostic Significance in Diffuse Large B-cell Lymphoma (Nature Communications, Mar 2024) Read More »

Deciphering the Regulatory Landscape of Murine Splenic Response to Anemic Stress at Single-cell Resolution (Blood Advances, Feb 2024)

Chong Yang 1, Rui Yokomori 1, Lee Hui Chua 1, Shi Hao Tan 1, Mun Yee Koh 1, Haruhito Totani 1, Takaomi Sanda 1, Toshio Suda 1 2 Affiliations 1Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 2International …

Deciphering the Regulatory Landscape of Murine Splenic Response to Anemic Stress at Single-cell Resolution (Blood Advances, Feb 2024) Read More »

Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer (Cancer Research Communications – AACR Journals, Jan 2024)

Kazuto Suda 1, Atsushi Okabe 2, Junichi Matsuo 1, Linda Shyue Huey Chuang 1, Ying Li 1, Nawaphat Jangphattananont 1, Naing Naing Mon 1, Khine Nyein Myint 1, Akihiro Yamamura 1, Jimmy Bok-Yan So 3, Dominic Chih-Cheng Voon 4, Henry Yang 1, Khay Guan Yeoh 5 6, Atsushi Kaneda 2, Yoshiaki Ito 1 Affiliations 1Cancer Science Institute of Singapore, National …

Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer (Cancer Research Communications – AACR Journals, Jan 2024) Read More »

A Glycolytic Metabolite Bypasses “two-hit” Tumor Suppression by BRCA2 (Cell, Apr 2024)

Kong LR, Gupta K, Wu AJ, Perera D, Ivanyi-Nagy R, Ahmed SM, Tan TZ, Tan SL, Fuddin A, Sundaramoorthy E, Goh GS, Wong RTX, Costa ASH, Oddy C, Wong H, …

A Glycolytic Metabolite Bypasses “two-hit” Tumor Suppression by BRCA2 (Cell, Apr 2024) Read More »

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