{"id":32457,"date":"2022-11-11T09:01:31","date_gmt":"2022-11-11T09:01:31","guid":{"rendered":"https:\/\/csi.nus.edu.sg\/?post_type=researcher&#038;p=32457"},"modified":"2023-05-05T11:51:53","modified_gmt":"2023-05-05T03:51:53","slug":"motomi-osato","status":"publish","type":"researcher","link":"https:\/\/csi.nus.edu.sg\/researcher\/motomi-osato\/","title":{"rendered":"Motomi OSATO"},"content":{"rendered":"\n\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/csi.nus.edu.sg\/wp-content\/uploads\/2022\/11\/motomi.png\" alt=\"motomi\" itemprop=\"image\" title=\"motomi\" onerror=\"this.style.display='none'\"  \/>\n<h3>Motomi OSATO<\/h3>\n<p>We are investigating the mechanism behind the development of leukaemia by analyses of a key leukaemia gene, RUNX1. Through these studies, we aim to develop novel diagnostic and therapeutic methods. To achieve this, we use a range of experimental platforms, such as mouse models as well as standard biological and chemical techniques. Our best known research accomplishment is the detection of RUNX1 point mutation in acute myeloid leukaemia. This genetic change is included in the World Health Organization (WHO) leukaemia classification and being examined globally whenever a leukaemia diagnosis is made.<\/p>\n<p>csimo[at]nus.edu.sg<\/p>\n\t\t\t\tAffiliations\n\t\t\t\tHonors &#038; Awards\n\t\t\t\t Research\n\t\t\t\tPublications\n\t\t\t\t\t\t\tAffiliations\n\t\t\t\t<p>Principal Investigator, Cancer Science Institute of Singapore, National University of Singapore<br \/>Research Associate Professor, Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore<br \/>Professor (visiting), International Research Center for Medical Sciences, Kumamoto University, Japan<\/p>\n\t\t\t\t\t\t\tHonors &#038; Awards\n\t\t\t\t\t\t\t Research\n<p><strong>Leukemia research towards novel therapeutics<\/strong><\/p>\n<p>We have been interrogating the mechanistic basis for leukemogenesis through the analyses of a key leukemia gene, RUNX1, aiming for the development of novel diagnostic and therapeutic methods (Figure 1). Treatment of RUNX leukemia has a dismal outcome and novel therapeutic approaches are needed. Our experimental platforms inlcude a mouse system (knockout or transgenic mice), and molecular and cellular analyses on clinical samples. Using such strategy, we have identified many diagnostic markers and treatment methods.<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/csi.nus.edu.sg\/wp-content\/uploads\/2022\/11\/mo_fig1.jpg\" alt=\"\" width=\"600\" height=\"675\" \/><\/p>\n<p><strong>Identification of cis-regulatory elements associated with human diseases<\/strong><\/p>\n<p>Human genome consists of 1.5% of coding and 98.5% of non-coding regions. Approximately 40% of disease-related genetic changes are expected to be located within the non-coding region, particularly in cis-regulatory elements (enhancer, silencer, locus control region, and insulator) which govern expression of genes. Genetic alterations in non-coding (intronic and intergenic) regions in RUNX loci have also been suspected to be the underlying mechanism for multiple human diseases; however, cis-elements for Runx family genes remain largely unknown. Employing our own unique strategy as shown in Figure 2, we have identified multiple cis-regulatory elements. Single nucleotide polymorphisms (SNPs) within these elements would serve as predictive risk factors for human diseases, whereas pharmaceutical modulation of the elements would lead to novel therapeutic directions.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/csi.nus.edu.sg\/wp-content\/uploads\/2022\/11\/mo_fig2.jpg\" alt=\"\" width=\"600\" height=\"624\" \/><\/p>\n\t\t\t\t\t\t\tPublications\n\t\t\t\t<div class=\"fl-builder-content fl-builder-content-32461 fl-builder-template fl-builder-row-template fl-builder-global-templates-locked\" data-post-id=\"32461\"><div class=\"fl-row fl-row-fixed-width fl-row-bg-none fl-node-uq5tv2px7wcb fl-row-default-height fl-row-align-center\" data-node=\"uq5tv2px7wcb\">\n\t<div class=\"fl-row-content-wrap\">\n\t\t<div class=\"uabb-row-separator uabb-top-row-separator\" >\n<\/div>\n\t\t\t\t\t\t<div class=\"fl-row-content fl-row-fixed-width fl-node-content\">\n\t\t\n<div class=\"fl-col-group fl-node-xhc2ovrlz8je\" data-node=\"xhc2ovrlz8je\">\n\t\t\t<div class=\"fl-col fl-node-qe1ijuznvhmy fl-col-bg-color\" data-node=\"qe1ijuznvhmy\">\n\t<div class=\"fl-col-content fl-node-content\">\t\t<div class=\"fl-module fl-module-button fl-node-hjqoz6resiax\" data-node=\"hjqoz6resiax\">\n\t<div class=\"fl-module-content fl-node-content\">\n\t\t<div class=\"fl-button-wrap fl-button-width-auto fl-button-center fl-button-has-icon\">\n\t\t\t<a href=\"https:\/\/scholar.google.com.sg\/citations?user=AQf-NpEAAAAJ&#038;hl=en\" target=\"_self\" class=\"fl-button\">\n\t\t\t\t\t<i class=\"fl-button-icon fl-button-icon-before fas fa-graduation-cap\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t<span class=\"fl-button-text\">Google Scholar Cititations<\/span>\n\t\t\t\t\t<\/a>\n<\/div>\n\t<\/div>\n<\/div>\n<\/div>\n<\/div>\n\t<\/div>\n\n<div class=\"fl-col-group fl-node-a2f1gnd9kcb8\" data-node=\"a2f1gnd9kcb8\">\n\t\t\t<div class=\"fl-col fl-node-ykazgp6leq87 fl-col-bg-color\" data-node=\"ykazgp6leq87\">\n\t<div class=\"fl-col-content fl-node-content\">\t\t<div class=\"fl-module fl-module-rich-text fl-node-0av5jk6irzw9\" data-node=\"0av5jk6irzw9\">\n\t<div class=\"fl-module-content fl-node-content\">\n\t\t<div class=\"fl-rich-text\">\n\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34148054\">1. Abdallah MG, Niibori-Nambu A, Morii M, Yokomizo T, Yokomizo T, Ideue T, Kubota S, Teoh VSI, Mok MMH, Wang CQ, Omar AA, Tokunaga K, Iwanaga E, Matsuoka M, Asou N, Nakagata N, Araki K, AboElenin M, Madboly SH, Sashida G,\u00a0<strong><u>Osato M<\/u><\/strong>. RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner.\u00a0<em><strong>Leukemia 2021<\/strong>\u00a0<\/em>, Online ahead of print<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27670082\">2. Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain Z, Heng DL, Kohu K, Voon DCC, Hiai H, Unno M, So JBY, Zhu F, Srivastava S, Meng T, Yeoh KG,\u00a0<strong><u>Osato M*<\/u><\/strong>, Ito Y*. *co-corresponding author. Identification of stem cells in the epithelium of the stomach corpus and antrum of mice.\u00a0<em><strong>Gastroenterology<\/strong>\u00a0<\/em>152:218-31, 2017<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26165235\">3. Chin DW, Watanabe-Okochi N, Wang CQ, Tergaonkar V,\u00a0<strong><u>Osato M<\/u><\/strong>. Mouse models for Core Binding Factor leukemia.\u00a0<em><strong>Leukemia<\/strong>\u00a0<\/em>29:1970-80, 2015<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25970242\">4. Koh CM, Bezzi M, Low HP, Ang WX, Teo SX, Gay FP, Al-Haddawi M, Tan SY,\u00a0<strong><u>Osato M<\/u><\/strong>, Sab\u00f2 A, Amati B, Wee KB, Guccione E. MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis.\u00a0<em><strong>Nature<\/strong>\u00a0<\/em>523:96-100, 2015<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25066130\">5. Wang QC, Krishnan V, Tay LS, Chooi JY, Chin DWL, Koh CP, Chooi JY, Nah GSK, Du L, Jacob B, Yamashita N, Tan TZ, Mori S, Taniuchi I, Tergaonkar V, Ito Y,\u00a0<strong><u>Osato M<\/u><\/strong>. Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.\u00a0<em><strong>Cell Reports<\/strong>\u00a0<\/em>8:767-82, 2014<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23741011\">6. Wang QXC, Motoda L, Satake M, Ito Y, Taniuchi I, Tergaonkar V,\u00a0<strong><u>Osato M<\/u><\/strong>. Runx3 deficiency results in myeloproliferative disorder in aged mice.\u00a0<em><strong>Blood<\/strong>\u00a0<\/em>122:562-66, 2013<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20799333\">7. Ng ELC, Yokomizo T, Yamashita N, Cirovic B, Jin H, Wen Z, Ito Y,\u00a0<strong><u>Osato M<\/u><\/strong>. A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells.\u00a0<em><strong>Stem Cells<\/strong><\/em>\u00a028:1869-81, 2010<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15156185\">8.\u00a0<strong><u>Osato M<\/u><\/strong>. Point Mutations in the RUNX1\/AML1 Gene: Another Actor in RUNX Leukemia.\u00a0<strong><em>Oncogene<\/em><\/strong>\u00a023:4284\u201396, 2004<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12464175\">9. Taniuchi I,\u00a0<strong><u>Osato M<\/u><\/strong>, Egawa T, Sunshine MJ, Bae S.C., Komori T, Ito Y and Littman DR. Requirement for Runx proteins in CD4 silencing at different stages of T lymphocyte development.\u00a0<em><strong>Cell<\/strong><\/em>\u00a0111: 621-33, 2002<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10068652\">10.\u00a0<strong><u>Osato M<\/u><\/strong>, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T, Suzushima H, Takatsuki K, Kanno T, Shigesada K, Ito Y. Biallelic and heterozygous point mutations in the runt domain of the AML1\/PEBP2alphaB associated with myeloblastic leukemias.\u00a0<em><strong>Blood<\/strong>\u00a0<\/em>93:1817-24, 1999<\/a><\/p>\n<\/div>\n\t<\/div>\n<\/div>\n<\/div>\n<\/div>\n\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n<\/div><div class=\"uabb-js-breakpoint\" style=\"display: none;\"><\/div>\t\t\t\n\t\t<h2>\n\t\t\tLab Members\n\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t<!-- Overlay Wrapper -->\n\t\t\t\t\t\t\t\t\t\t<p><b>Akiko NAMBU<\/b><br \/>Research Scientist<br \/>Antibody therapy for RUNX leukemia<\/p>\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t <!-- Overlay Wrapper Closed -->\n\t\t\t\t\t\t\t\t\t\t\t<!-- Overlay Wrapper -->\n\t\t\t\t\t\t\t\t\t\t<p><b>Michelle Meng Huang MOK<\/b><br \/>PhD student<br \/>RUNX family genes in hematopoiesis and leukemogenesis<\/p>\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t <!-- Overlay Wrapper Closed -->\n\t\t\t\t\t\t\t\t\t\t\t<!-- Overlay Wrapper -->\n\t\t\t\t\t\t\t\t\t\t<p><b>Bibek DUTTA<\/b><br \/>PhD student<br \/>RUNX and RNA in hematopoiesis and leukemogenesis<\/p>\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t <!-- Overlay Wrapper Closed -->\n\t\t\t\t\t\t\t\t\t\t\t<!-- Overlay Wrapper -->\n\t\t\t\t\t\t\t\t\t\t<p><b>LAI Si Kei<\/b><br \/>Laboratory Executive<br \/>Flow cytometer operation and mouse care<\/p>\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t <!-- Overlay Wrapper Closed -->\n\t\t\t\t\t\t\t\t\t\t\t<!-- Overlay Wrapper -->\n\t\t\t\t\t\t\t\t\t\t<p><b>Vania TEOH<\/b><br \/>Research Assistant<br \/>Flow cytometer operation and mouse care<\/p>\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t <!-- Overlay Wrapper Closed -->\n\t\t\t\t\t\t\t\t\t\t\t<!-- Overlay Wrapper -->\n\t\t\t\t\t\t\t\t\t\t<p><b>THAM Cheng Yong<\/b><br \/>Research Fellow<br \/>Endogenous retroelement involvement in leukemogenesis<\/p>\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t <!-- Overlay Wrapper Closed -->\n\t\t\t\t\t\t\t\t\t\t\t<!-- Overlay Wrapper -->\n\t\t\t\t\t\t\t\t\t\t<p><b>Hiroaki Kitamura<\/b><br \/>Research Fellow<br \/>Drug development against RUNX leukemia<\/p>\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t <!-- Overlay Wrapper Closed -->\n\t\t\t\t\t\t\t\t<!-- navigation arrows -->\n\t\t\t<button aria-label=\"Previous slide\" role=\"button\" tabindex=\"0\">\n\t\t\t<\/button>\n\t\t\t<button aria-label=\"Next slide\" role=\"button\" tabindex=\"0\">\n\t\t\t<\/button>\n\t\t\t\t\t\t<!-- pagination -->\n\t\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","footnotes":""},"class_list":["post-32457","researcher","type-researcher","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Motomi OSATO - NUS CSI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/csi.nus.edu.sg\/researcher\/motomi-osato\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Motomi OSATO - NUS CSI\" \/>\n<meta property=\"og:description\" content=\"Motomi OSATO We are investigating the mechanism behind the development of leukaemia by analyses of a key leukaemia gene, RUNX1. 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