BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//NUS CSI - ECPv6.11.0.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://csi.nus.edu.sg
X-WR-CALDESC:Events for NUS CSI
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
TZNAME:UTC
DTSTART:20190101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=UTC:20190805T040000
DTEND;TZID=UTC:20190805T050000
DTSTAMP:20260513T183422
CREATED:20230120T002014Z
LAST-MODIFIED:20230130T014044Z
UID:47882-1564977600-1564981200@csi.nus.edu.sg
SUMMARY:Research Seminar by Li Yan McCurdy\, Yale University\, USA
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/research-seminar-by-li-yan-mccurdy-yale-university-usa/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190808T060000
DTEND;TZID=UTC:20190808T070000
DTSTAMP:20260513T183422
CREATED:20230120T002214Z
LAST-MODIFIED:20230130T013921Z
UID:47888-1565244000-1565247600@csi.nus.edu.sg
SUMMARY:[IMRE Seminar] Rapid Discovery\, Manufacturing\, and Delivery of Bioactive Proteins and Antisense Oligonucleotides
DESCRIPTION:Thur\, 8 August 2019 \n2.00pm – 3.00pm \n  \nIMRE\, Kinesis Building\, \nSeminar Room 1\, Level 5 \n  \n  \n \nRapid discovery\, manufacturing\, and delivery of bioactive proteins and antisense oligonucleotides \nSpeaker: Prof. Bradley L. Pentelute\, Associate Professor of Chemistry\, Massachusetts Institute of Technology \nHost : Dr. Kedar Hippalgaonkar\, Electronic Materials Department\, IMRE \nAbstract \nAntisense oligonucleotides\, proteins and other biopolymers serve as a foundation of modern therapeutics for the treatment of diseases ranging from cancer to diabetes. The discovery\, manufacturing\, and delivery of these biomolecules into cells is often a challenge and limits rapid translation to the clinic. Here I describe our latest findings on the development of a platform for discovery of peptide drug leads from 100 million-member synthetic libraries. Our best lead compounds efficiently disrupt cancer-specific protein-protein interactions in cells. We also aim to overcome the cytosolic delivery barrier with cell-penetrating peptides\, chemical vectors that facilitate cellular permeation and nuclear targeting of antisense cargoes. The properties of these peptide-based materials were positively altered with macrocyclization chemistry\, specifically by cysteine arylation. These modifications impart the ability to cross biological barriers\, including the blood-brain barrier and plasma membrane\, allowing the therapeutic biopolymers to strike their target and correct cellular function. We applied machine learning algorithms to our vast data set on cellular penetration and predicted novel peptide materials to transport into cells large oligonucleotides (6\,500 Da) that may treat Duchenne muscular dystrophy. Manufacturing our new cell-penetrating drug leads and oligonucleotides is hindered by the rate at which we synthesize them\, which is far slower than Nature’s production pace of seconds. Realizing this\, we have built table top machines that that use man-made chemistry to synthesize peptides in minutes and proteins in hours. Our next steps are to layer on reinforcement learning to each of these platforms while introducing them to clinicians\, enabling the rapid advancement of innovative medicines into clinical trials. \n  \nAbout the speaker \nBradley L. Pentelute\, Associate Professor of Chemistry. He is also an Associate Member\, Broad Institute of Harvard and MIT\, an Extramural Member of the MIT Koch Cancer Institute\, and Member\, Center for Environmental Health Sciences MIT. He received his undergraduate degree in Psychology and Chemistry from the University of Southern California\, and his M.S and Ph.D. in Organic Chemistry from the University of Chicago with Prof. Steve Kent.  He was a postdoctoral fellow in the laboratory of Dr. R. John Collier at Harvard Medical School\, Microbiology. \nClick here to register \nFor further enquiries\, please contact Dr Kedar Hippalgaonkar ( kedarh@imre.a-star.edu.sg)
URL:https://csi.nus.edu.sg/event/imre-seminar-rapid-discovery-manufacturing-and-delivery-of-bioactive-proteins-and-antisense-oligonucleotides/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190822T030000
DTEND;TZID=UTC:20190822T043000
DTSTAMP:20260513T183422
CREATED:20230120T002256Z
LAST-MODIFIED:20230130T013415Z
UID:47892-1566442800-1566448200@csi.nus.edu.sg
SUMMARY:Seminar - A Complete Cancer Workflow - Isolating Pure Primary Cell Populations
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/seminar-a-complete-cancer-workflow-isolating-pure-primary-cell-populations/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190823T030000
DTEND;TZID=UTC:20190823T040000
DTSTAMP:20260513T183422
CREATED:20230120T001704Z
LAST-MODIFIED:20230130T013403Z
UID:47855-1566529200-1566532800@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 23 Aug
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting-23-aug/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190826T030000
DTEND;TZID=UTC:20190826T040000
DTSTAMP:20260513T183422
CREATED:20230120T001758Z
LAST-MODIFIED:20230130T013354Z
UID:47874-1566788400-1566792000@csi.nus.edu.sg
SUMMARY:CSI Seminar - Jan Cools
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-jan-cools/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190827T030000
DTEND;TZID=UTC:20190827T040000
DTSTAMP:20260513T183422
CREATED:20230120T002257Z
LAST-MODIFIED:20230130T012840Z
UID:47893-1566874800-1566878400@csi.nus.edu.sg
SUMMARY:CSI Seminar - Chew Guo Liang
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-chew-guo-liang-2/
END:VEVENT
END:VCALENDAR