BEGIN:VCALENDAR
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PRODID:-//NUS CSI - ECPv6.11.0.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://csi.nus.edu.sg
X-WR-CALDESC:Events for NUS CSI
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
TZNAME:UTC
DTSTART:20190101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=UTC:20190503T030000
DTEND;TZID=UTC:20190503T030000
DTSTAMP:20260520T065717
CREATED:20230120T001736Z
LAST-MODIFIED:20230130T015959Z
UID:47868-1556852400-1556852400@csi.nus.edu.sg
SUMMARY:CSI Seminar - Claudio Tripodo
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-claudio-tripodo/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190508T070000
DTEND;TZID=UTC:20190508T080000
DTSTAMP:20260520T065717
CREATED:20230120T001736Z
LAST-MODIFIED:20230130T015927Z
UID:47867-1557298800-1557302400@csi.nus.edu.sg
SUMMARY:CSI Seminar - Chen Jianjun
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-chen-jianjun/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190510T050000
DTEND;TZID=UTC:20190510T060000
DTSTAMP:20260520T065717
CREATED:20230120T001539Z
LAST-MODIFIED:20230130T015746Z
UID:47837-1557464400-1557468000@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 10 May
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting-10-may/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190514T030000
DTEND;TZID=UTC:20190514T040000
DTSTAMP:20260520T065717
CREATED:20230120T001737Z
LAST-MODIFIED:20230120T001737Z
UID:47869-1557802800-1557806400@csi.nus.edu.sg
SUMMARY:RNA Biology Centre Meeting – 14 May
DESCRIPTION:Scientific work presentation:Speaker: Huang Hua (from Soong Tuck Wah’s group)\n1st short talk title: Evolutionary conservation and physiological roles of A-to-I RNA editing in CaV1.3 channels\nAbstract:\nWe have reported that voltage gated calcium channel CaV1.3 undergoes ADAR2 mediated A-to-I RNA editing in a developmental and tissue selective fashion. Our recent paper demonstrated such editing is dictated by an intronic editing complementary sequence (ECS) that forms RNA duplex structure with the edited exon 41. Intriguingly\, in silico alignment in the encode database demonstrated high conservation of ECS and exonic sequence across vertebrates. Correlatingly\, editing of CaV1.3 mRNA was observed in most of experimental animal models such as rodents\, pig\, zebra fishes and macaque. Further tissues profiling of zebra fishes reports lack of editing in peripheral tissues such as muscle and testis\, a trend similarly observed in rodents and human. Behaviour study showed mice lack of editing of Cav1.3 displayed longer retention of fear memory. We have similarly deleted the ECS sequence in zebra fish. Experiments are underway to understand the physiological roles of such molecular event in evolution. \n2nd short talk title: Identification of tandem pore domain potassium channel KCNK5 as a novel target in Ph+ CML\nAbstract:\nPotassium channels are pore-forming transmembrane proteins that regulate a variety of cellular processes via controlling the potassium flow across biological membrane. Accumulating data implicates the dysregulation of potassium channel expression in different types of cancer. In the present study\, quantitative real-time PCR reported overexpression of KCNK5 mRNA in K562 cells and Ph+ CML bone marrow samples as compared to normal bone marrow. Moreover\, the expression of the KCNK5 mRNA and protein in K562 cells are sensitive to imatinib that blocks BCR-ABL tyrosine-kinase activity. In silico analysis of the Chip-seq database revealed strong interaction of c-MYC and Max binding to the promoter region of KCNK5\, suggesting that BCR-ABL induced ectopic expression of the channel via Jak2 and c-MYC pathway. Sub-cellular fractionation experiment detects enrichment of KCNK5 channels in the lysosomal fraction\, suggesting the potential function of the channels in regulating cellular metabolism. KCNK5 specific blocker clofilium inhibits channel function and proliferation of K562 cells. CRISPR/Cas9 mediated gene knockout (KO) in K562 cells suppresses tumor formation in mouse xenograft model. By tail vein injection\, mice engrafted with KO cells survived significantly longer than mice transplanted with control cells. Taken together the study reports identification of KCNK5 potentially as a novel target in Ph+ CML.
URL:https://csi.nus.edu.sg/event/rna-biology-centre-meeting-14-may/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190524T050000
DTEND;TZID=UTC:20190524T060000
DTSTAMP:20260520T065717
CREATED:20230120T001540Z
LAST-MODIFIED:20230130T015725Z
UID:47838-1558674000-1558677600@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 24 May
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting-24-may/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190527T060000
DTEND;TZID=UTC:20190527T090000
DTSTAMP:20260520T065717
CREATED:20230120T001758Z
LAST-MODIFIED:20230120T001758Z
UID:47872-1558936800-1558947600@csi.nus.edu.sg
SUMMARY:Bioinformatics Club
DESCRIPTION:Title: Increase efficiency of OMICs data analysis and interpretation with MetaCoreSpeaker:  Sonya Novikova\, Solutions Scientist from Clarivate Analytics \nAbstract: \nMetaCore is a systems biology database with in-build tools and workflows for OMICs data analysis and biological interpretation. Data contained within MetaCore is industry leading in accuracy\, reliability\, and comprehensiveness\, manually curated by PhD and MD level research professionals and updated quarterly. Key Pathway Advisor (KPA)\, a MetaCore’s complementary solution\, enhances MetaCore’s data analysis workflows by using MetaCore’s content and state-of-the-art algorithms\, causal reasoning and Signaling Pathway Impact Anlaysis (SPIA)\, to predict key protein activity changes that could be the root cause for the changes observed in your data and shows how biological pathways are impacted by your data. Integrate your experimental research with manually-curated molecular interactions and pathways for pivotal insights and decision making\, particularly in \n\nIdentifying signaling pathways and processes affected by your gene lists or expression data Understand molecular mechanisms of disease and/or drug action\nOverlaying and visualize your gene lists or expression data on pathways and networks Enhance results interpretation and accuracy – find drug targets and/or biomarkers\nDiscovering key hubs overconnected to your genes (e.g. key transcription factors that potentially drive observed gene expression changes) Look beyond your gene list/ expression data – use network of interaction to find “hidden nodes”\nConnecting your molecules of interest to reveal hidden relationships Understand molecular mechanisms of disease and/or drug action\n\nAll are welcome. Bring your gene lists which you want to find out the pathways or interaction networks. The online access to the pathway/network analysis suites will be provided. However\, you will need to bring your own laptop for online trial analyses; Tea/Coffee and few snacks will be provided \nVenue: Conference room at Level 12\, MD6\nTime: May 27\, 2019\, 2.00-5.00pm (including 2+hr for online trial analyses with your own gene sets) \n 
URL:https://csi.nus.edu.sg/event/bioinformatics-club-2/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190528T030000
DTEND;TZID=UTC:20190528T040000
DTSTAMP:20260520T065717
CREATED:20230120T001623Z
LAST-MODIFIED:20230120T001623Z
UID:47850-1559012400-1559016000@csi.nus.edu.sg
SUMMARY:RNA Biology Centre Meeting - 28 May
DESCRIPTION:To be updated
URL:https://csi.nus.edu.sg/event/rna-biology-centre-meeting-28-may/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190528T060000
DTEND;TZID=UTC:20190528T070000
DTSTAMP:20260520T065717
CREATED:20230120T001720Z
LAST-MODIFIED:20230130T015637Z
UID:47862-1559023200-1559026800@csi.nus.edu.sg
SUMMARY:CSI Seminar - Daniel Hodson
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-daniel-hodson/
END:VEVENT
END:VCALENDAR