BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//NUS CSI - ECPv6.11.0.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:NUS CSI
X-ORIGINAL-URL:https://csi.nus.edu.sg
X-WR-CALDESC:Events for NUS CSI
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
TZNAME:UTC
DTSTART:20170101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=UTC:20170210T000000
DTEND;TZID=UTC:20170327T090000
DTSTAMP:20260418T142425
CREATED:20230119T224544Z
LAST-MODIFIED:20230130T044422Z
UID:47692-1486684800-1490605200@csi.nus.edu.sg
SUMMARY:CSI-ENS Bioinformatics Workshop
DESCRIPTION:Registration is CLOSED.\nClick here for program
URL:https://csi.nus.edu.sg/event/csi-ens-bioinformatics-workshop/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20170210T030000
DTEND;TZID=UTC:20170210T040000
DTSTAMP:20260418T142425
CREATED:20230119T224545Z
LAST-MODIFIED:20230130T044350Z
UID:47694-1486695600-1486699200@csi.nus.edu.sg
SUMMARY:RNA Club
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/rna-club/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20170216T080000
DTEND;TZID=UTC:20170216T090000
DTSTAMP:20260418T142425
CREATED:20230119T224600Z
LAST-MODIFIED:20230119T224600Z
UID:47698-1487232000-1487235600@csi.nus.edu.sg
SUMMARY:Bioinformatics Club
DESCRIPTION:Bioinformatics Club\nVenue: Level 12 Conference Room \nTime: 16 Feb 2017\, 4pm \nSpeaker: Samuel Collombet \nDeciphering the regulatory network controlling blood cell specification through ChiP-seq meta-analysis and dynamical modelling \nAbstract:\nBlood cells arise from a common set of hematopoietic stem cells that differentiate into more specific progenitors\, ultimately leading to different functional lineages. This process relies on the activation and repression of different genes modules\, controlled by transcription factors (TFs). Novel high-throughput technologies allow the identification of cell-specific regulatory elements by characterising chromatin states and TFs binding sites\, in conjunction with gene expression profiling. Proper integration and analysis of these data enable the delineation of novel regulatory interactions\, which can be modelled and analysed using formal methods\, thereby fostering our understanding of the mechanisms controlling cell fate at a system level\, and enabling the prediction of the effects of molecular perturbations in silico. Combining public and novel data from molecular genetic experiments (qPCR\, western blot\, EMSA) or genome-wide assays (RNA-seq\, ChIP-seq)\, we have assembled a comprehensive regulatory network encompassing the main transcription factors and signalling components involved in myeloid and lymphoid lineage development. Using a multilevel logical framework\, we built a dynamical model allowing us to simulate cells differentiation\, commitment and reprogramming in silico. To improve the accuracy of our model\, we performed a meta-analysis of available TF ChIP-seq datasets for myeloid and lymphoid cells\, confirming previously known regulations or confirming new ones (26 confirmed and 66 predicted regulations). We then iteratively included some predicted regulations in our model\, performed static or dynamical analysis (stables states analysis or differentiation/reprogramming simulations)\, and compared the results with gene expression data and phenotypes. This approach enabled us to predict several important\, previously unknown regulations\, which were further confirmed experimentally. Finally we used our model to delineate novel trans-differentiation protocols that can be tested experimentally.
URL:https://csi.nus.edu.sg/event/bioinformatics-club/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20170217T040000
DTEND;TZID=UTC:20170217T050000
DTSTAMP:20260418T142425
CREATED:20230119T224515Z
LAST-MODIFIED:20230130T044314Z
UID:47683-1487304000-1487307600@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 17 Feb
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting-17-feb/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20170220T030000
DTEND;TZID=UTC:20170220T040000
DTSTAMP:20260418T142425
CREATED:20230119T224601Z
LAST-MODIFIED:20230130T044251Z
UID:47699-1487559600-1487563200@csi.nus.edu.sg
SUMMARY:CSI Seminar - Jerry Workman
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-jerry-workman/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20170221T030000
DTEND;TZID=UTC:20170221T040000
DTSTAMP:20260418T142425
CREATED:20230119T224559Z
LAST-MODIFIED:20230130T044232Z
UID:47696-1487646000-1487649600@csi.nus.edu.sg
SUMMARY:CSI Seminar - Daan Noordermeer
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-daan-noordermeer/
END:VEVENT
END:VCALENDAR