NUS CSI

RNA Club - Katsutomo Okamura
2017-06-06 03:00 - 04:00 UTC

RNA Biology Centre Meeting
2017-06-05 07:00 - 09:00
By Invitation Only
Date: Monday, 5 June 2017
Time: 3pm
Venue: Level 12 Conference Room, MD6
Prof Daniel Tenen will present his project.
Title: DNMT3B-DNA and RNA interactions

CSI Research Meeting - 2 Jun
2017-06-02 04:00 - 05:00

CSI Distinguished Speakers' Series - Prof Ashok Venkitaraman
2017-05-23 03:00 - 04:00

CSI Advances-in-Research (AIR)
2017-05-19 08:30 - 09:30

CSI Research Meeting - 19 May
2017-05-19 04:00 - 05:00

BOCA Pow-Wow
2017-05-16 08:30 - 09:30

CSI Research Meeting - 5 May
2017-05-05 04:00 - 05:00

CSI Seminar - Jose Cancelas
2017-05-02 03:00 - 04:00

SRBA Meeting
2017-04-25 08:00 - 10:00

RNA Biology Centre Meeting
2017-04-24 07:00 - 09:00
By Invitation Only
Date: Monday, 24 April 2017
Time: 3pm
Venue: Level 12 Conference Room, MD6
Dr Sudhakar Jha will present his project.
Title: Noncoding RNAs Regulating Epigenetic Pathways in Leukemia

CSI Research Meeting - 21 Apr
2017-04-21 04:00 - 05:00

RNA Club - Simon Conn
2017-04-21 03:00 - 04:00

CSI Seminar - Li Chai
2017-04-20 07:00 - 08:00

CSI Research Meeting - 7 Apr
2017-04-07 04:00 - 05:00

CSI Research Meeting - 24 March
2017-03-24 04:00 - 05:00
The annual CSI State-of-the-Institute address will commence at 12pm on 24 March.All CSI staff and students should attend.
The CSI Research Meeting will continue after the address.

RNA Club - Zhang Li-Feng
2017-03-23 03:00 - 04:00

CSI Seminar - Andrei Zinovyev
2017-03-21 03:00 - 04:00

RNA Club - Herve Le Hir
2017-03-13 03:00 - 04:00

CSI Advances In Research (AIR)
2017-03-10 08:30 - 10:00

CSI Research Meeting - 10 Mar
2017-03-10 04:00 - 05:00

RNA Biology Centre Meeting
2017-03-02 06:00 - 07:00
By Invitation Only
Date: Thur, 2 Mar 2017
Time: 2pm
Venue: Level 12 Conference Room, MD6
Takaomi Sanda’s group will present their progress in the sub-project: “Identification of a Novel long Non-Coding RNA Regulated by the TAL1 Transcriptional Complex in T-cell Acute Lymphoblastic Leukemia”.

CSI Seminar - Daan Noordermeer
2017-02-21 03:00 - 04:00

CSI Seminar - Jerry Workman
2017-02-20 03:00 - 04:00

CSI Research Meeting - 17 Feb
2017-02-17 04:00 - 05:00

Bioinformatics Club
2017-02-16 08:00 - 09:00
Bioinformatics Club
Venue: Level 12 Conference Room
Time: 16 Feb 2017, 4pm
Speaker: Samuel Collombet
Deciphering the regulatory network controlling blood cell specification through ChiP-seq meta-analysis and dynamical modelling
Abstract:
Blood cells arise from a common set of hematopoietic stem cells that differentiate into more specific progenitors, ultimately leading to different functional lineages. This process relies on the activation and repression of different genes modules, controlled by transcription factors (TFs). Novel high-throughput technologies allow the identification of cell-specific regulatory elements by characterising chromatin states and TFs binding sites, in conjunction with gene expression profiling. Proper integration and analysis of these data enable the delineation of novel regulatory interactions, which can be modelled and analysed using formal methods, thereby fostering our understanding of the mechanisms controlling cell fate at a system level, and enabling the prediction of the effects of molecular perturbations in silico. Combining public and novel data from molecular genetic experiments (qPCR, western blot, EMSA) or genome-wide assays (RNA-seq, ChIP-seq), we have assembled a comprehensive regulatory network encompassing the main transcription factors and signalling components involved in myeloid and lymphoid lineage development. Using a multilevel logical framework, we built a dynamical model allowing us to simulate cells differentiation, commitment and reprogramming in silico. To improve the accuracy of our model, we performed a meta-analysis of available TF ChIP-seq datasets for myeloid and lymphoid cells, confirming previously known regulations or confirming new ones (26 confirmed and 66 predicted regulations). We then iteratively included some predicted regulations in our model, performed static or dynamical analysis (stables states analysis or differentiation/reprogramming simulations), and compared the results with gene expression data and phenotypes. This approach enabled us to predict several important, previously unknown regulations, which were further confirmed experimentally. Finally we used our model to delineate novel trans-differentiation protocols that can be tested experimentally.

RNA Club
2017-02-10 03:00 - 04:00

CSI-ENS Bioinformatics Workshop
2017-02-10 00:00 - 2017-03-27 09:00
Registration is CLOSED.
Click here for program

BOCA Pow-Wow
2017-01-24 02:00 - 15:00
Breast and Ovarian Cancers (BOCA) Pow-Wow
Day/Date: Tuesday, 24 January 2017
Time: 10am-11am
Venue, #01-01A Learning Room, Level 1, MD6

Speakers:

Shreya Kar – PhD Student, Dr Alan Prem Kumar’s Group

Poh Han Ming – PhD Student, Prof Peter Lobie’s Group

Singapore RNA Biology Alliance Inaugural Meeting
2017-01-16 06:00 - 09:00
More information here: https://srba-rna.org/
