NUS CSI

CSI Research Meeting - 6 Apr
2018-04-06 05:00 - 06:00 UTC

French-Singaporean Symposium
2018-04-12 01:00 - 2018-04-13 09:00
RNA Biology applied to Leukemia research
Paris, 12-13 April 2018

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CSI Seminar - Ruan Yijun
2018-04-16 07:00 - 08:00

CSI Research Meeting - 20 Apr
2018-04-20 05:00 - 06:00

CSI Seminar - Michael Menden
2018-05-03 03:00 - 04:00

Abcam-CSI Cancer Symposium
2018-05-04 00:30 - 09:00
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Industry Presentation - Biorad (Richard Harrison)
2018-05-17 03:00 - 04:00

CSI Seminar - Stefan Dentro
2018-05-18 02:30 - 03:30

CSI Research Meeting - 18 May
2018-05-18 07:00 - 08:00

RNA Biology Centre Meeting
2018-05-21 07:00 - 08:00
By Invitation Only
Date: Monday, 21 May 2018
Time: 3pm
Venue: Level 12 Conference Room, MD6
Presenter:
Title:

CSI Seminar - Roland Ivanyi-Nagy
2018-05-25 03:00 - 04:00

CSI Seminar - Andreas Strasser
2018-05-25 07:00 - 08:00

CSI Research Meeting - 1 June
2018-06-01 05:00 - 06:00

RNA Biology Centre Meeting - 4 Jun
2018-06-04 07:00 - 08:00
By Invitation Only
Date: Monday, 4 June 2018
Time: 3pm
Venue: Level 12 Conference Room, MD6
Presenter: Dr Dennis Kappei
Title: Transcriptional regulation in the lymphatic and leukaemic context

CSI Seminar - Han Xu
2018-07-03 07:00 - 08:00

CSI Seminar - Todd Stukenberg
2018-07-04 07:00 - 08:00
To be updated

CSI Seminar - Victoria Cowling
2018-07-05 03:00 - 04:00

CSI Research Meeting - 6 July
2018-07-06 05:00 - 06:00

CSI Seminar - Yana Zavros
2018-07-17 02:00 - 15:00

RNA Biology Centre Meeting - 19 July
2018-07-19 03:00 - 04:00
By Invitation Only
Speaker: Prof Chng Wee Joo
Date: 19 July 2018, Thursday
Time: 11am
Venue: MD6, Level 12 Conference Room (#12-02N)
Title: EZH2 may methylate SRSF1 and affect its function in CML
Abstract:
EZH2 is the enzymatic component of the PRC2 complex which plays an important role in Histone modification and gene regulation. However, we and others have shown that EZH2 can also methylate non-histone proteins as well as interacts with other proteins and RNA leading to alternate functions and effect on gene expression. In an attempt to understand these non-canonical functions, we performed proteomics study to identify interacting partners with EZH2. In our proteomics study, EZH2 interacts with a large number of splicing factor. We validated that SRSF1 is one of the splicing factor that can be methylated by EZH2. SRSF1 has oncogenic function in CML and this is mediated partly by methylation induced by EZH2.

CSI Seminar - Brendan Jenkins
2018-07-20 02:00 - 03:00

CSI Research Meeting - 20 July
2018-07-20 05:00 - 06:00

CSI Seminar - Mark Chao
2018-07-23 20:00 - 2018-07-24 09:00

SRBA Meeting - 25 July
2018-07-25 08:00 - 09:30

CSI Research Meeting - 17 Aug
2018-08-17 05:00 - 06:00

RNA Biology Centre Meeting - 20 Aug
2018-08-20 06:00 - 07:00
By Invitation Only
Date: Monday, 20 August 2018
Time: 2pm
Venue: Level 12 Conference Room, MD6
Presenter: Dr Kar Tong Tan
Title: Exploring C-to-U changes in mRNA in terms of both RNA editing and RNA modification using large-scale data
C-to-U changes in mRNA are often interpreted as C-to-U RNA editing. Like ADARs for A-to-G RNA editing, APOBEC1 is usually considered as the major factor to mediate C-to-U RNA editing. Recently, base-pair-disrupting mRNA modifications have been reported. Such modifications may also include C-to-U modifications. As uracil generated by C-to-U editing is still capable of undergoing Watson-Crick base-pairing, we need to distinguish these two C-to-U RNA change modes for better identification of their corresponding factors and cofactors. Based on the RNA modification signatures, we have developed a sophisticated statistical model which can separate C-to-U base-pair-disrupting modification from editing. Applying a large-data screening method to both RNA modification and editing sites separately, we are in a better position to identify potential factors mediating either modification or editing. The screening method involves linking of the RNA modification or editing sites with individual genes/RBPs/enzymes by site clustering, high vs low expression grouping and expression correlation.

CSI Research Meeting - 7 Sep
2018-09-07 05:00 - 06:00

RNA Symposium Satellite Workshops 2018 - 10 & 11 Sep
2018-09-09 16:00 - 2018-09-11 15:59

RNA Biology Symposium 2018
2018-09-13 01:00 - 2018-09-15 10:00

CSI Seminar - Richard Eglen
2018-10-03 20:30 - 2018-10-04 09:30
