CSI Research Meeting - 20 July
2018-07-20 05:00 - 06:00 UTC

CSI Seminar - Mark Chao
2018-07-23 20:00 - 2018-07-24 09:00

SRBA Meeting - 25 July
2018-07-25 08:00 - 09:30

CSI Research Meeting - 17 Aug
2018-08-17 05:00 - 06:00

RNA Biology Centre Meeting - 20 Aug
2018-08-20 06:00 - 07:00
By Invitation Only
Date: Monday, 20 August 2018
Time: 2pm
Venue: Level 12 Conference Room, MD6
Presenter: Dr Kar Tong Tan
Title: Exploring C-to-U changes in mRNA in terms of both RNA editing and RNA modification using large-scale data
C-to-U changes in mRNA are often interpreted as C-to-U RNA editing. Like ADARs for A-to-G RNA editing, APOBEC1 is usually considered as the major factor to mediate C-to-U RNA editing. Recently, base-pair-disrupting mRNA modifications have been reported. Such modifications may also include C-to-U modifications. As uracil generated by C-to-U editing is still capable of undergoing Watson-Crick base-pairing, we need to distinguish these two C-to-U RNA change modes for better identification of their corresponding factors and cofactors. Based on the RNA modification signatures, we have developed a sophisticated statistical model which can separate C-to-U base-pair-disrupting modification from editing. Applying a large-data screening method to both RNA modification and editing sites separately, we are in a better position to identify potential factors mediating either modification or editing. The screening method involves linking of the RNA modification or editing sites with individual genes/RBPs/enzymes by site clustering, high vs low expression grouping and expression correlation.

CSI Research Meeting - 7 Sep
2018-09-07 05:00 - 06:00

RNA Symposium Satellite Workshops 2018 - 10 & 11 Sep
2018-09-09 16:00 - 2018-09-11 15:59

RNA Biology Symposium 2018
2018-09-13 01:00 - 2018-09-15 10:00

CSI Seminar - Richard Eglen
2018-10-03 20:30 - 2018-10-04 09:30

CSI Research Meeting - 5 Oct
2018-10-05 05:00 - 06:00

CSI Seminar - Massimo Tommasino
2018-10-08 02:00 - 15:00

RNA Club - 9 Oct
2018-10-09 03:00 - 04:00

RNA Biology Centre Meeting
2018-10-15 07:00 - 08:00
By Invitation Only
Date: Monday, 15 Oct 2018
Time: 3pm
Venue: Level 12 Conference Room, MD6
Presenter:
Title:

CSI Seminar - H. Leighton Grimes
2018-10-16 06:30 - 07:30

CSI Research Meeting - 19 Oct
2018-10-19 05:00 - 06:00

CSI-TBSI Joint Symposium on Precision Approaches in Cancer
2018-11-05 00:00 - 09:00

CSI-CityU Joint RNA Symposium
2018-11-06 01:00 - 10:30

Frontiers in Cancer Science 2018
2018-11-12 01:00 - 2018-11-14 10:00

CSI Seminar - Li Chai
2018-12-06 06:30 - 07:30

CSI Seminar - Hubert Hondermarck
2018-12-12 02:30 - 15:30

CSI Seminar - Tannishtha Reya
2018-12-21 02:30 - 15:30

RNA Biology Centre Meeting - 8 Jan
2019-01-08 03:00 - 04:00
By Invitation Only
Date: 8 Jan 2019, Tuesday
Time: 11am
Venue: MD6, Level 12 Conference Room (#12-02N)

Updates from:
– Prof. Dan Tenen on MOE Tier 3 grant
– Dr Melissa Fullwood on RNA Epigenomics Core – Personnel updates; LncRNA microarray updates

Scientific Presentation:
Speaker: Wei Wen TEO (Prof Daniel Tenen’s group)
Title: Non-coding RNA Mediates Long-range Regulation of ?-Globin by Inhibiting EZH2

Abstract:
The best established function of EZH2-RNA interaction is gene inactivation. Nevertheless, several lines of evidence indicates that repression might not be the only function of EZH2-RNA interaction .In this study, we investigate the functional role of EZH2-RNA interaction in K562 cells. RIP analysis reveals that EZH2 binds to a non-coding RNA (HBE-ER) transcribed upstream of ?-globin cluster. Depletion of HBE-ER in K562 cells enhances the methyl-transferase activity of EZH2 at the corresponding locus, suggesting a cis-acting role of HBE-ER at the genomic locus. HBE-ER transcript permits the distal chromatin interaction between its locus and the locus control region (LCR) of ?-globin. Paused expression of HBE-ER releases its locus engagement with the LCR, thereby allowing the enhancer to contact with HBE1 promoter. This results in the activation of HBE1 transcription, which is evidenced by the enhanced Pol2 binding at its promoter. The transcription of HBE-ER is negatively regulated by oxygen depletion. In contrast, HBE1 level increases under hypoxia, suggesting an oxygen sensing role for controlling the expression of HBE1 by HBE-ER.

CSI Seminar - Constanze Bonifer & Peter Cockerill
2019-01-11 00:00 - 09:00

CSI Seminar - Charles David
2019-01-18 02:00 - 03:00

CSI Seminar - Chiang Cheng-Ming
2019-01-18 06:30 - 07:30

CSI Distinguished Speakers’ Series – Samuel Waxman
2019-01-21 06:30 - 07:30

CSI Research Meeting - 25 Jan
2019-01-25 05:00 - 06:00

CSI Distinguished Speakers’ Series – Reuben Harris
2019-02-18 00:00 - 09:00

SRBA Meeting - 21 Feb
2019-02-21 08:00 - 09:30

CSI Research Meeting - 22 Feb
2019-02-22 05:00 - 06:00
