BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//NUS CSI - ECPv6.11.0.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:NUS CSI
X-ORIGINAL-URL:https://csi.nus.edu.sg
X-WR-CALDESC:Events for NUS CSI
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:UTC
BEGIN:STANDARD
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
TZNAME:UTC
DTSTART:20190101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=UTC:20190218T000000
DTEND;TZID=UTC:20190218T090000
DTSTAMP:20260421T120648
CREATED:20230120T001608Z
LAST-MODIFIED:20230130T023940Z
UID:47846-1550448000-1550480400@csi.nus.edu.sg
SUMMARY:CSI Distinguished Speakers’ Series – Reuben Harris
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-distinguished-speakers-series-reuben-harris/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190221T080000
DTEND;TZID=UTC:20190221T093000
DTSTAMP:20260421T120648
CREATED:20230120T001720Z
LAST-MODIFIED:20230130T023921Z
UID:47861-1550736000-1550741400@csi.nus.edu.sg
SUMMARY:SRBA Meeting - 21 Feb
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/srba-meeting-21-feb-2/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190222T050000
DTEND;TZID=UTC:20190222T060000
DTSTAMP:20260421T120648
CREATED:20230119T230229Z
LAST-MODIFIED:20230130T023845Z
UID:47788-1550811600-1550815200@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 22 Feb
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting-22-feb/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190226T030000
DTEND;TZID=UTC:20190226T040000
DTSTAMP:20260421T120648
CREATED:20230120T001609Z
LAST-MODIFIED:20230120T001609Z
UID:47848-1551150000-1551153600@csi.nus.edu.sg
SUMMARY:RNA Biology Centre Meeting - 26 Feb
DESCRIPTION:Venue: Level 12 Conference Room\nTime: 11am \nScientific work presentation: \nSpeaker: Xin Yi LOH (Prof H. Phillip Koeffler’s group) \nTitle: ZFP36L1 suppresses hypoxia and cell cycle signaling \nAbstract: \nZFP36L1 is a tandem zinc-finger RNA binding protein (RBP) that recognizes conserved Adenylate-Uridylate-rich elements (AU-rich elements\, AREs) located in 3’untranslated regions (UTRs) mediating mRNAs decay process. Here\, we hypothesized that ZFP36L1 is a negative regulator of a post-transcriptional hub involving in mRNA half-life regulation of cancer-related transcripts. To identify the direct downstream targets of ZFP36L1\, a systematic screening using RNA pull-down and whole transcriptome sequencing of bladder cancer cells ± ZFP36L1 was performed. Analysis of in silico data revealed that ZFP36L1 is significantly mutated\, epigenetically silenced and downregulated in a variety of cancers. Forced expression of ZFP36L1 in cancer cells markedly reduced in vitro and in vivo cell proliferation; whereas silencing of ZFP36L1 enhanced tumor cells growth. We identified a network of 1\,410 targets\, which were bound by wildtype\, but not zinc finger mutant ZFP36L1. These targets included a number of key oncogenic transcripts\, such as HIF-1?\, CCND1 and E2F1. ZFP36L1 specifically bound to 3’UTRs of these targets for mRNA degradation\, thus suppressing their mRNA and protein expressions. Dual luciferase reporter assays and RNA Electro-Mobility Shift Assays (RNA-EMSA) showed that wildtype\, but not zinc finger mutant ZFP36L1\, bound to HIF-1? 3’UTR and mediated HIF-1? mRNA degradation. This eventually leads to reduced expressions of HIF-1? and its downstream targets in metabolism and angiogenesis. Collectively\, our findings shed light on the pathophysiology of bladder tumorigenesis and revealed an indispensable role of ZFP36L1 as a posttranscriptional safeguard against aberrant hypoxic signaling and abnormal cell cycle progression.
URL:https://csi.nus.edu.sg/event/rna-biology-centre-meeting-26-feb/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190227T063000
DTEND;TZID=UTC:20190227T073000
DTSTAMP:20260421T120648
CREATED:20230120T001454Z
LAST-MODIFIED:20230130T023824Z
UID:47823-1551249000-1551252600@csi.nus.edu.sg
SUMMARY:CSI Seminar - Peter Kharchenko
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-peter-kharchenko/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190304T030000
DTEND;TZID=UTC:20190304T040000
DTSTAMP:20260421T120648
CREATED:20230120T001623Z
LAST-MODIFIED:20230130T023804Z
UID:47851-1551668400-1551672000@csi.nus.edu.sg
SUMMARY:RNA Club – 4 Mar
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/rna-club-4-mar/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190305T080000
DTEND;TZID=UTC:20190305T090000
DTSTAMP:20260421T120648
CREATED:20230120T001734Z
LAST-MODIFIED:20230130T023748Z
UID:47865-1551772800-1551776400@csi.nus.edu.sg
SUMMARY:CSI Seminar - Simón Méndez-Ferrer
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-simon-mendez-ferrer/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190307T030000
DTEND;TZID=UTC:20190307T040000
DTSTAMP:20260421T120648
CREATED:20230120T001721Z
LAST-MODIFIED:20230130T023241Z
UID:47864-1551927600-1551931200@csi.nus.edu.sg
SUMMARY:[CANCELLED] CSI Seminar - Yan Chuan
DESCRIPTION:Due to unforeseen circumstances\, this seminar is CANCELLED.
URL:https://csi.nus.edu.sg/event/cancelled-csi-seminar-yan-chuan/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190308T050000
DTEND;TZID=UTC:20190308T060000
DTSTAMP:20260421T120648
CREATED:20230120T001525Z
LAST-MODIFIED:20230130T023215Z
UID:47833-1552021200-1552024800@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 8 March
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting-8-march/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190308T080000
DTEND;TZID=UTC:20190308T090000
DTSTAMP:20260421T120648
CREATED:20230120T001721Z
LAST-MODIFIED:20230130T022807Z
UID:47863-1552032000-1552035600@csi.nus.edu.sg
SUMMARY:CSI Seminar - Yoshiaki Kubota
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-yoshiaki-kubota/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190321T030000
DTEND;TZID=UTC:20190321T040000
DTSTAMP:20260421T120648
CREATED:20230120T001719Z
LAST-MODIFIED:20230130T022701Z
UID:47860-1553137200-1553140800@csi.nus.edu.sg
SUMMARY:CSI Seminar - Ichiro Taniuchi
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-ichiro-taniuchi-2/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190322T050000
DTEND;TZID=UTC:20190322T060000
DTSTAMP:20260421T120648
CREATED:20230120T001525Z
LAST-MODIFIED:20230130T022643Z
UID:47834-1553230800-1553234400@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 22 March
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting-22-march/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190405T050000
DTEND;TZID=UTC:20190405T060000
DTSTAMP:20260421T120648
CREATED:20230120T001538Z
LAST-MODIFIED:20230130T022602Z
UID:47835-1554440400-1554444000@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 5 April
DESCRIPTION:The CSI State-of-the-Institute address 2019 will commence at 1pm.Regular CSI Research Meeting talks as below will start after the State-of-the-Institute address\, followed by refreshments at 2.30pm.\nAll staff and students are encouraged to attend.
URL:https://csi.nus.edu.sg/event/csi-research-meeting-5-april/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190408T030000
DTEND;TZID=UTC:20190408T040000
DTSTAMP:20260421T120648
CREATED:20230120T001735Z
LAST-MODIFIED:20230130T022522Z
UID:47866-1554692400-1554696000@csi.nus.edu.sg
SUMMARY:RNA Club - 8 Apr
DESCRIPTION:Speaker: Dr Jordan SkittrallVenue: NUS\, MD6\, Level 12 conference room\nTime: 11 am\nTitle:  In silico prediction of RNA secondary structure and function using big data approaches to primary structures|\nHost: Prof. Andrew Lever \n 
URL:https://csi.nus.edu.sg/event/rna-club-8-apr/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T050000
DTEND;TZID=UTC:20190416T090000
DTSTAMP:20260421T120648
CREATED:20230120T001608Z
LAST-MODIFIED:20230130T022426Z
UID:47845-1555390800-1555405200@csi.nus.edu.sg
SUMMARY:Bioinformatics Workshop - 16 Apr
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/bioinformatics-workshop-16-apr/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T222955Z
LAST-MODIFIED:20230119T222955Z
UID:47373-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:CSI-Advances in Research (AIR) Meeting
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-advances-in-research-air-meeting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T222956Z
LAST-MODIFIED:20230119T222956Z
UID:47374-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:16th Asia-Pacific International Molecular Biology Network Conference
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/16th-asia-pacific-international-molecular-biology-network-conference/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T222957Z
LAST-MODIFIED:20230119T222957Z
UID:47375-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:Joint SGCC-CSI Gastric Cancer Seminar
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/joint-sgcc-csi-gastric-cancer-seminar/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T222958Z
LAST-MODIFIED:20230119T222958Z
UID:47377-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:CSI RESEARCH MEETING
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T222958Z
LAST-MODIFIED:20230119T222958Z
UID:47376-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:CSI-Advances in Research – YONG Kol Jia
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-advances-in-research-yong-kol-jia/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T222959Z
LAST-MODIFIED:20230130T022316Z
UID:47378-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:Frontiers in Cancer Science 2015
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/frontiers-in-cancer-science-2015/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T223014Z
LAST-MODIFIED:20230119T223014Z
UID:47382-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 16 Jun
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting-16-jun/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T223014Z
LAST-MODIFIED:20230119T223014Z
UID:47383-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:NUS Scientists Develop Novel Chemical "Dye" to Improve Liver Cancer Imaging
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/nus-scientists-develop-novel-chemical-dye-to-improve-liver-cancer-imaging/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T223015Z
LAST-MODIFIED:20230119T223015Z
UID:47384-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:NUS-CMU Joint Symposium
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/nus-cmu-joint-symposium/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T223028Z
LAST-MODIFIED:20230119T223028Z
UID:47387-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:SRBA Meeting - 21 Feb
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/srba-meeting-21-feb/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T223028Z
LAST-MODIFIED:20230119T223028Z
UID:47385-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:CSI Seminar - Li Chai
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-li-chai/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190416T070700
DTEND;TZID=UTC:20190416T070700
DTSTAMP:20260421T120648
CREATED:20230119T223028Z
LAST-MODIFIED:20230119T223028Z
UID:47386-1555398420-1555398420@csi.nus.edu.sg
SUMMARY:RNA Club – 9 OCT
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/rna-club-9-oct/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190423T030000
DTEND;TZID=UTC:20190423T040000
DTSTAMP:20260421T120648
CREATED:20230120T001610Z
LAST-MODIFIED:20230120T001610Z
UID:47849-1555988400-1555992000@csi.nus.edu.sg
SUMMARY:RNA Biology Centre Meeting - 23 Apr
DESCRIPTION:Venue: Level 12 Conference Room\nTime: 11am \nScientific work presentation: \nSpeaker: Shi Hao TAN (from Takaomi Sanda’s group) \nTitle: Identification of Long Non-Coding RNAs Regulated by the TAL1 Complex in T-cell Acute Lymphoblastic Leukemia \nAbstract: \nTAL1/SCL is one of the most prevalent oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). TAL1 and its regulatory partners (GATA3\, RUNX1\, and MYB) positively regulate each other and coordinately regulate the expression of their downstream target genes in T-ALL cells. However\, long non-coding RNAs (lncRNAs) regulated by these factors are largely unknown. Here we established a bioinformatics pipeline and analyzed RNA-seq datasets to identify lncRNAs regulated by TAL1 in T-ALL. Our analysis predicted 57 putative lncRNAs that are activated by TAL1\, many of which were regulated by GATA3\, RUNX1\, and MYB in a coordinated manner. We identified two novel transcripts that were activated in multiple T-ALL cell samples but were downregulated in normal thymocytes. One novel lncRNA transcript near the ARID5B gene locus which we named ARIEL (ARID5B Inducing Enhancer-associated Long Non-Coding RNA) was specifically expressed in TAL1-positive T-ALL cases. ARID5B was recently identified as important for T-ALL leukemogenesis and we further explored the role of the neighbourhood lncRNA ARIEL. Further analysis our Chip-seq data showed that ARIEL is aberrantly expressed from the -135kb enhancer region of ARID5B in TAL1-positive cells. Knockdown of ARIEL resulted in a significant decrease of the levels of ARID5B at the mRNA and protein levels together with a loss of chromatin interaction between this enhancer and ARID5B promoter region as observed by 4C-seq. We also show through RNA Immunoprecipitation (RIP) that ARIEL is able to interact with Mediator 12. Overall\, our study shows that the ARIEL can act as an enhancer RNA to regulate expression of the oncogenic ARID5B by mediating enhancer-promoter chromatin interaction in T-ALL leukemogenesis.
URL:https://csi.nus.edu.sg/event/rna-biology-centre-meeting-23-apr/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190426T050000
DTEND;TZID=UTC:20190426T060000
DTSTAMP:20260421T120648
CREATED:20230120T001539Z
LAST-MODIFIED:20230130T020427Z
UID:47836-1556254800-1556258400@csi.nus.edu.sg
SUMMARY:CSI Research Meeting - 26 April
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-research-meeting-26-april/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20190429T030000
DTEND;TZID=UTC:20190429T040000
DTSTAMP:20260421T120648
CREATED:20230120T001624Z
LAST-MODIFIED:20230130T020046Z
UID:47852-1556506800-1556510400@csi.nus.edu.sg
SUMMARY:RNA Club - 29 Apr
DESCRIPTION:Speaker: Assoc Prof. LU JinhuaVenue: NUS\, MD6\, Level 12 conference room\nTime: 11 am\nTitle:  Ribosome biogenesis and regulation\nHost: Dr Polly Chen \n 
URL:https://csi.nus.edu.sg/event/rna-club-29-apr/
END:VEVENT
END:VCALENDAR