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DTSTART:20180101T000000
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DTSTART;TZID=UTC:20180820T060000
DTEND;TZID=UTC:20180820T070000
DTSTAMP:20260410T052342
CREATED:20230119T230228Z
LAST-MODIFIED:20230119T230228Z
UID:47787-1534744800-1534748400@csi.nus.edu.sg
SUMMARY:RNA Biology Centre Meeting - 20 Aug
DESCRIPTION:By Invitation Only\nDate: Monday\, 20 August 2018\nTime: 2pm\nVenue: Level 12 Conference Room\, MD6 \nPresenter: Dr Kar Tong Tan\nTitle: Exploring C-to-U changes in mRNA in terms of both RNA editing and RNA modification using large-scale data \nC-to-U changes in mRNA are often interpreted as C-to-U RNA editing. Like ADARs for A-to-G RNA editing\, APOBEC1 is usually considered as the major factor to mediate C-to-U RNA editing. Recently\, base-pair-disrupting mRNA modifications have been reported. Such modifications may also include C-to-U modifications. As uracil generated by C-to-U editing is still capable of undergoing Watson-Crick base-pairing\, we need to distinguish these two C-to-U RNA change modes for better identification of their corresponding factors and cofactors. Based on the RNA modification signatures\, we have developed a sophisticated statistical model which can separate C-to-U base-pair-disrupting modification from editing. Applying a large-data screening method to both RNA modification and editing sites separately\, we are in a better position to identify potential factors mediating either modification or editing. The screening method involves linking of the RNA modification or editing sites with individual genes/RBPs/enzymes by site clustering\, high vs low expression grouping and expression correlation.
URL:https://csi.nus.edu.sg/event/rna-biology-centre-meeting-20-aug/
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