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DTSTART:20180101T000000
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DTSTART;TZID=UTC:20180719T030000
DTEND;TZID=UTC:20180719T040000
DTSTAMP:20260410T114317
CREATED:20230119T235800Z
LAST-MODIFIED:20230119T235800Z
UID:47817-1531969200-1531972800@csi.nus.edu.sg
SUMMARY:RNA Biology Centre Meeting - 19 July
DESCRIPTION:By Invitation Only\nSpeaker: Prof Chng Wee Joo\nDate: 19 July 2018\, Thursday\nTime: 11am\nVenue: MD6\, Level 12 Conference Room (#12-02N)\nTitle: EZH2 may methylate SRSF1 and affect its function in CML \nAbstract:\nEZH2 is the enzymatic component of the PRC2 complex which plays an important role in Histone modification and gene regulation. However\, we and others have shown that EZH2 can also methylate non-histone proteins as well as interacts with other proteins and RNA leading to alternate functions and effect on gene expression. In an attempt to understand these non-canonical functions\, we performed proteomics study to identify interacting partners with EZH2. In our proteomics study\, EZH2 interacts with a large number of splicing factor. We validated that SRSF1 is one of the splicing factor that can be methylated by EZH2. SRSF1 has oncogenic function in CML and this is mediated partly by methylation induced by EZH2.
URL:https://csi.nus.edu.sg/event/rna-biology-centre-meeting-19-july/
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