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X-WR-CALNAME:NUS CSI
X-ORIGINAL-URL:https://csi.nus.edu.sg
X-WR-CALDESC:Events for NUS CSI
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TZNAME:UTC
DTSTART:20180101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20180208T030000
DTEND;TZID=UTC:20180208T040000
DTSTAMP:20260626T034920
CREATED:20230119T234759Z
LAST-MODIFIED:20230130T035814Z
UID:47790-1518058800-1518062400@csi.nus.edu.sg
SUMMARY:CSI Seminar - George Muscat
DESCRIPTION:
URL:https://csi.nus.edu.sg/event/csi-seminar-george-muscat/
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BEGIN:VEVENT
DTSTART;TZID=UTC:20180208T070000
DTEND;TZID=UTC:20180208T080000
DTSTAMP:20260626T034920
CREATED:20230119T230027Z
LAST-MODIFIED:20230119T230027Z
UID:47782-1518073200-1518076800@csi.nus.edu.sg
SUMMARY:RNA Biology Centre Meeting - 8 Feb
DESCRIPTION:By Invitation Only\nDate: Thursday\, 8 Feb 2018\nTime: 3pm\nVenue: Level 12 Conference Room\, MD6 \nPresenter: Dr Melissa Fullwood\nTitle: Towards understanding the interplay between RNA and chromatin interactions in leukemia \nAbstract: \nLeukemias demonstrate aberrant gene expression\, with the generation of abnormal long non-coding and coding RNA. Recent findings suggest an interplay between RNA and chromatin interactions – RNA can regulate chromatin interactions and chromatin interactions regulate the genesis of RNA. Here\, we try to get better understanding of chromatin interactions from two aspects: 1) through their association with stretched cis-regulatory elements such as super-enhancers and broad H3K4me3 domains that are important in cell identity maintenance; 2) through predicting chromatin interactions from 1-dimentional epigenetic marks and DNA sequences\, respectively\, and investigate the epigenetic marks and DNA sequence features that are important for accurate prediction. Stretched regulatory elements showed high association with chromatin interactions and can confer higher cell-type specificities of target genes through chromatin interactions. We examined the problems of current state-of-art computational methods for predicting chromatin interactions and demonstrated that chromatin interactions can be accurately predicted from epigenetic marks as well as from pure DNA sequences. In the future\, we hope that this work will be useful in building up a better understanding of the interplay between RNA and chromatin interactions.
URL:https://csi.nus.edu.sg/event/rna-biology-centre-meeting-8-feb/
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